Negatively Charged Strangelet Search using the E864 Spectrometer at the AGS

We provide a status report on the progress of searching for negatively charged strangelets using the E864 spectrometer at the AGS. About 200 million recorded events representing approximately 14 billion 10% central interactions of Au + Pt at 11.5 GeV/c taken during the 1996-1997 run of the experiment are used in the analysis. No strangelet candidates are seen for charges Z=-1 and Z=-2, corresponding to a 90% confidence level for upper limits of strangelet production of ~1 x 10^{-8} and ~4 x 10^{-9} per central collision respectively. The limits are nearly uniform over a wide range of masses and are valid only for strangelets which are stable or have lifetimes greater than ~50 ns.Comment: 6 pages, 4 figures; Talk at SQM'98, Padova, Italy (July 20-24, 1998

Detection of nonthermal emission from the bow shock of a massive runaway star

The environs of massive, early-type stars have been inspected in recent years in the search for sites where particles can be accelerated up to relativistic energies. Wind regions of massive binaries that collide have already been established as sources of high-energy emission; however, there is a different scenario for massive stars where strong shocks can also be produced: the bow-shaped region of matter piled up by the action of the stellar strong wind of a runaway star interacting with the interstellar medium. We study the bow-shock region produced by a very massive runaway star, BD+43 3654, to look for nonthermal radio emission as evidence of a relativistic particle population. We observed the field of BD+43 3654 at two frequencies, 1.42 and 4.86 GHz, with the Very Large Array (VLA), and obtained a spectral index map of the radio emission. We have detected, for the first time, nonthermal radio emission from the bow shock of a massive runaway star. After analyzing the radiative mechanisms that can be at work, we conclude that the region under study could produce enough relativistic particles whose radiation might be detectable by forthcoming gamma-ray instruments, like CTA North.Comment: Accepted in Astronomy and Astrophysics Letter

Correcting for Distortions due to Ionization in the STAR TPC

Physics goals of the STAR Experiment at RHIC in recent (and future) years drive the need to operate the STAR TPC at ever higher luminosities, leading to increased ionization levels in the TPC gas. The resulting ionic space charge introduces field distortions in the detector which impact tracking performance. Further complications arise from ionic charge leakage into the main TPC volume from the high gain anode region. STAR has implemented corrections for these distortions based on measures of luminosity, which we present here. Additionally, we highlight a novel approach to applying the corrections on an event-by-event basis applicable in conditions of rapidly varying ionization sources.Comment: 6 pages, 7 figures, proceedings of the Workshop on Tracking in High Multiplicity Environments (TIME 05) in Zurich, Switzerland, submitted to Nucl. Instr. and Meth.

A very massive runaway star from Cygnus OB2

Aims: We analyze the available information on the star BD+43 3654 to investigate the possibility that it may have had its origin in the massive OB association Cygnus OB2. Methods: We present new spectroscopic observations allowing a reliable spectral classification of the star, and discuss existing MSX observations of its associated bow shock and astrometric information not previously studied. Results: Our observations reveal that BD+43 3654 is a very early and luminous star of spectral type O4If, with an estimated mass of (70 +/- 15) solar masses and an age of about 1.6 Myr. The high spatial resolution of the MSX observations allows us to determine its direction of motion in the plane of the sky by means of the symmetry axis of the well-defined bow shock, which matches well the orientation expected from the proper motion. Tracing back its path across the sky we find that BD+43 3654 was located near the central, densest region of Cygnus OB2 at a time in the past similar to its estimated age. Conclusions: BD+43 3654 turns out to be one of the three most massive runaway stars known, and it most likely formed in the central region of Cygnus OB2. A runaway formation mechanism by means of dynamical ejection is consistent with our results.Comment: Accepted by Astronomy and Astrophysics (letters); 5 pages, 3 figure

Balance functions in coalescence model

It is shown that the quark-antiquark coalescence mechanism for pion production allows to explain the small width of the balance function observed for central collisions of heavy ions, provided effects of the finite acceptance region and of the transverse flow are taken into account. In contrast, the standard hadronic cluster model is not compatible with this data.Comment: 12 pages, 1 figur

Hepatocellular carcinoma survival in uninsured and underinsured patients.

BACKGROUND: The incidence of hepatitis C virus (HCV) and hepatocellular carcinoma (HCC) is increasing. The purpose of this study is to establish baseline survival in a medically-underserved population and to evaluate the effect of HCV seropositivity on our patient population. MATERIALS AND METHODS: We reviewed clinicopathologic parameters from a prospective tumor registry and medical records from the Harris County Hospital District (HCHD). Outcomes were compared using Kaplan-Meier survival analysis and log-rank tests. RESULTS: A total of 298 HCC patients were identified. The median survival for the entire cohort was 3.4 mo. There was no difference in survival between the HCV seropositive and the HCV seronegative groups (3.6 mo versus 2.6 mo, P = 0.7). Patients with a survival \u3c1 mo had a significant increase in\u3eαfetoprotein (AFP), international normalized ratio (INR), model for end-stage liver disease (MELD) score, and total bilirubin and decrease in albumin compared with patients with a survival ≥ 1 mo. CONCLUSIONS: Survival for HCC patients in the HCHD is extremely poor compared with an anticipated median survival of 7 mo reported in other studies. HCV seropositive patients have no survival advantage over HCV seronegative patients. Poorer liver function at diagnosis appears to be related to shorter survival. Further analysis into variables contributing to decreased survival is needed

Optical Observations of the Binary Pulsar System PSR B1718-19: Implications for Tidal Circularization

We report on Keck and Hubble Space Telescope optical observations of the eclipsing binary pulsar system PSR B1718-19, in the direction of the globular cluster NGC 6342. These reveal a faint star ($m_{\rm F702W}=25.21\pm0.07$; Vega system) within the pulsar's 0\farcs5 radius positional error circle. This may be the companion. If it is a main-sequence star in the cluster, it has radius \rcomp\simeq0.3 \rsun, temperature \teff\simeq3600 K, and mass \mcomp\simeq0.3 \msun. In many formation models, however, the pulsar (spun up by accretion or newly formed) and its companion are initially in an eccentric orbit. If so, for tidal circularization to have produced the present-day highly circular orbit, a large stellar radius is required, i.e., the star must be bloated. Using constraints on the radius and temperature from the Roche and Hayashi limits, we infer from our observations that \rcomp\simlt0.44 \rsun and \teff\simgt3300 K. Even for the largest radii, the required efficiency of tidal dissipation is larger than expected for some prescriptions.Comment: 10 pages, 2 figures, aas4pp2.sty. Accepted for publication in Ap

C16-Ceramide Analog Combined with Pc 4 Photodynamic Therapy Evokes Enhanced Total Ceramide Accumulation, Promotion of DEVDase Activation in the Absence of Apoptosis, and Augmented Overall Cell Killing

Because of the failure of single modality approaches, combination therapy for cancer treatment is a promising alternative. Sphingolipid analogs, with or without anticancer drugs, can improve tumor response. C16-pyridinium ceramide analog LCL30, was used in combination with photodynamic therapy (PDT), an anticancer treatment modality, to test the hypothesis that the combined treatment will trigger changes in the sphingolipid profile and promote cell death. Using SCCVII mouse squamous carcinoma cells, and the silicone phthalocyanine Pc 4 for PDT, we showed that combining PDT with LCL30 (PDT/LCL30) was more effective than individual treatments in raising global ceramide levels, as well as in reducing dihydrosphingosine levels. Unlike LCL30, PDT, alone or combined, increased total dihydroceramide levels. Sphingosine levels were unaffected by LCL30, but were abolished after PDT or the combination. LCL30-triggered rise in sphingosine-1-phosphate was reversed post-PDT or the combination. DEVDase activation was evoked after PDT or LCL30, and was promoted post- PDT/LCL30. Neither mitochondrial depolarization nor apoptosis were observed after any of the treatments. Notably, treatment with the combination resulted in augmented overall cell killing. Our data demonstrate that treatment with PDT/LCL30 leads to enhanced global ceramide levels and DEVDase activation in the absence of apoptosis, and promotion of total cell killing

Sequential drain amylase to guide drain removal following pancreatectomy

BACKGROUND: Although used as criterion for early drain removal, postoperative day (POD) 1 drain fluid amylase (DFA) ≤ 5000 U/L has low negative predictive value for clinically relevant postoperative pancreatic fistula (CR-POPF). It was hypothesized that POD3 DFA ≤ 350 could provide further information to guide early drain removal. METHODS: Data from a pancreas surgery consortium database for pancreatoduodenectomy and distal pancreatectomy patients were analyzed retrospectively. Those patients without drains or POD 1 and 3 DFA data were excluded. Patients with POD1 DFA ≤ 5000 were divided into groups based on POD3 DFA: Group A (≤350) and Group B (>350). Operative characteristics and 60-day outcomes were compared using chi-square test. RESULTS: Among 687 patients in the database, all data were available for 380. Fifty-five (14.5%) had a POD1 DFA > 5000. Among 325 with POD1 DFA ≤ 5000, 254 (78.2%) were in Group A and 71 (21.8%) in Group B. Complications (35 (49.3%) vs 87 (34.4%); p = 0.021) and CR-POPF (13 (18.3%) vs 10 (3.9%); p < 0.001) were more frequent in Group B. CONCLUSIONS: In patients with POD1 DFA ≤ 5000, POD3 DFA ≤ 350 may be a practical test to guide safe early drain removal. Further prospective testing may be useful