UV graviton scattering and positivity bounds from IR dispersion relations

Scattering amplitudes mediated by graviton exchange display IR singularities in the forward limit. This obstructs standard application of positivity bounds based on twice subtracted dispersion relations. Such divergences can be cancelled only if the UV limit of the scattering amplitude behaves in a specific way, which implies a very non-trivial connection between the UV and IR behaviors of the amplitude. We show that this relation can be expressed in terms of an integral transform, obtaining analytic results when $t \log{s}\rightarrow 0$. Carefully applying this limit to dispersion relations, we find that infinite arc integrals, which are usually taken to vanish, can give a non-trivial contribution in the presence of gravity, unlike in the case of finite negative $t$. This implies that gravitational positivity bounds cannot be trusted unless the size of this contribution is estimated in some way, which implies assumptions on the UV completion of gravitational interactions. We discuss the relevance of these findings in the particular case of QED coupled to gravity.Comment: 20 pages, 2 figure

Caracterización y conservación de la piedra usada en la Catedral de Granada, España

This paper summarizes a study carried out on the Granada Cathedral which includes studies of indicators, factors and mechanisms of deterioration. A complete chemical and physical characterization of altered and unaltered material from the quarries and the building has been made. Eight commercial treatment products have been tested on the main stone-type used in the monument, including two accelerated weathering tests (salt crystallization and SO2 chemical attack). Some conservation proposals have been made.Este artículo recoge un estudio llevado a cabo sobre la Catedral de Granada que incluye la determinación de los indicadores, factores y mecanismos de deterioro. Asimismo se ha realizado una completa caracterización física y química del material alterado del edificio e inalterado de cantera. Se han probado ocho productos comerciales aplicados al principal tipo de piedra existente en el monumento, incluyendo la realización de dos ensayos de alteración acelerada (cristalización de sales y ataque químico con atmósfera de SO2. Como punto final se recogen algunas recomendaciones de cara a una posible intervención

Robotic-Assisted Laparoscopic Gynecologic Procedures in a Fellowship Training Program

An early evaluation of the feasibility of training fellows in robotic surgery suggests that it is feasible to incorporate a systematic approach to robotic-assisted laparoscopic training at the onset of incorporating this technology into current practice

Dynamic of plasmodium falciparum chloroquine resistance transporter gene Pfcrt K76T mutation five years after withdrawal of chloroquine in Burkina Faso

We investigated the evolution of Pfcrt K76T mutation five years after the withdrawal of chloroquine in Burkina Faso. A total of 675 clinical isolates collected from October 2010 to September 2012 were successfully genotyped. Single nucleotide polymorphism in Pfcrt (codon 76) gene was analyzed. The prevalence of resistant Pfcrt 76T allele was 20.55%. There was a progressive decrease of the proportion of mutant type pfcrt T76 from 2010 to 2012 (X2=5.508 p=0.0189). Our results suggest a progressive return of the wild type Pfcrt K76 in Burkina Faso but the prevalence of the mutants Pfcrt T76 still remains high

Cell-free (RNA) and cell-associated (DNA) HIV-1 and postnatal transmission through breastfeeding

<p>Introduction - Transmission through breastfeeding remains important for mother-to-child transmission (MTCT) in resource-limited settings. We quantify the relationship between cell-free (RNA) and cell-associated (DNA) shedding of HIV-1 virus in breastmilk and the risk of postnatal HIV-1 transmission in the first 6 months postpartum.</p> <p>Materials and Methods - Thirty-six HIV-positive mothers who transmitted HIV-1 by breastfeeding were matched to 36 non-transmitting HIV-1 infected mothers in a case-control study nested in a cohort of HIV-infected women. RNA and DNA were quantified in the same breastmilk sample taken at 6 weeks and 6 months. Cox regression analysis assessed the association between cell-free and cell-associated virus levels and risk of postnatal HIV-1 transmission.</p> <p>Results - There were higher median levels of cell-free than cell-associated HIV-1 virus (per ml) in breastmilk at 6 weeks and 6 months. Multivariably, adjusting for antenatal CD4 count and maternal plasma viral load, at 6 weeks, each 10-fold increase in cell-free or cell-associated levels (per ml) was significantly associated with HIV-1 transmission but stronger for cell-associated than cell-free levels [2.47 (95% CI 1.33–4.59) vs. aHR 1.52 (95% CI, 1.17–1.96), respectively]. At 6 months, cell-free and cell-associated levels (per ml) in breastmilk remained significantly associated with HIV-1 transmission but was stronger for cell-free than cell-associated levels [aHR 2.53 (95% CI 1.64–3.92) vs. 1.73 (95% CI 0.94–3.19), respectively].</p> <p>Conclusions - The findings suggest that cell-associated virus level (per ml) is more important for early postpartum HIV-1 transmission (at 6 weeks) than cell-free virus. As cell-associated virus levels have been consistently detected in breastmilk despite antiretroviral therapy, this highlights a potential challenge for resource-limited settings to achieve the UNAIDS goal for 2015 of eliminating vertical transmission. More studies would further knowledge on mechanisms of HIV-1 transmission and help develop more effective drugs during lactation.</p&gt

Analysis of factors influencing the ultrasonic fetal weight estimation

Objective: The aim of our study was the evaluation of sonographic fetal weight estimation taking into consideration 9 of the most important factors of influence on the precision of the estimation. Methods: We analyzed 820 singleton pregnancies from 22 to 42 weeks of gestational age. We evaluated 9 different factors that potentially influence the precision of sonographic weight estimation ( time interval between estimation and delivery, experts vs. less experienced investigator, fetal gender, gestational age, fetal weight, maternal BMI, amniotic fluid index, presentation of the fetus, location of the placenta). Finally, we compared the results of the fetal weight estimation of the fetuses with poor scanning conditions to those presenting good scanning conditions. Results: Of the 9 evaluated factors that may influence accuracy of fetal weight estimation, only a short interval between sonographic weight estimation and delivery (0-7 vs. 8-14 days) had a statistically significant impact. Conclusion: Of all known factors of influence, only a time interval of more than 7 days between estimation and delivery had a negative impact on the estimation

Nitrogen deposition alters nitrogen cycling and reduces soil carbon content in low-productivity semiarid Mediterranean ecosystems.

Anthropogenic N deposition poses a threat to European Mediterranean ecosystems. We combined data from an extant N deposition gradient (4.3–7.3 kg N ha−1 yr−1) from semiarid areas of Spain and a field experiment in central Spain to evaluate N deposition effects on soil fertility, function and cyanobacteria community. Soil organic N did not increase along the extant gradient. Nitrogen fixation decreased along existing and experimental N deposition gradients, a result possibly related to compositional shifts in soil cyanobacteria community. Net ammonification and nitrification (which dominated N-mineralization) were reduced and increased, respectively, by N fertilization, suggesting alterations in the N cycle. Soil organic C content, C:N ratios and the activity of β-glucosidase decreased along the extant gradient in most locations. Our results suggest that semiarid soils in low-productivity sites are unable to store additional N inputs, and that are also unable to mitigate increasing C emissions when experiencing increased N deposition

Extended Human Papillomavirus Genotyping to Predict Progression to High-Grade Cervical Precancer: A Prospective Cohort Study in the Southeastern United States

Background: High-risk human papillomavirus (hrHPV) testing (HPV16; else HPV18/45; else HPV31/33/35/52/58; else HPV39/ is utilized in primary cervical cancer screening, generally along with 51/56/59/68). cytology, to triage abnormalities to colposcopy. Most screening-Results: At enrollment, median participant age was 30.1 years; based hrHPV testing involves pooled detection of any hrHPV or of most (63%) were hrHPV-positive. Over follow-up, 24 participants HPV16/18. Cervical neoplasia progression risks based on extended progressed to CIN2þ (7.0%). CIN2þ IR among hrHPV-positive hrHPV genotyping—particularly non-16/18 hrHPV types—are not participants was 3.4/1,000 person-months. CIN2þ IRs were highest well characterized. HPV genotype-specific incidence of high-grade for HPV16 (8.3), HPV33 (7.8), and HPV58 (4.9). Five-year CIN2þ cervical intraepithelial neoplasia or more severe (CIN2þ) following risk was higher for HPV16 (0.34) compared with HPV18/45 (0.12), an abnormal screening result was examined. HPV31/33/35/52/58 (0.12), and HPV39/51/56/59/68 (0.16) (P ¼ 0.05). Methods: We assessed a US-based prospective, multiracial, Conclusions: Non-16/18 hrHPV types are associated with difclinical cohort of 343 colposcopy patients with normal histology ferential CIN2þ progression rates. HPV16, 33, and 58 exhibited the (n ¼ 226) or CIN1 (n ¼ 117). Baseline cervical samples underwent highest rates over 5 years. HPV risk groups warrant further invesHPV DNA genotyping, and participants were followed up to 5 years. tigation in diverse US populations. Genotype-specific CIN2þ incidence rates (IR) were estimated with Impact: These novel data assessing extended HPV genotyping in accelerated failure time models. Five-year CIN2þ risks were estia diverse clinical cohort can inform future directions to improve mated nonparametrically for hierarchical hrHPV risk groups screening practices in the general population