Discrete events simulation method for analyze cycle time: a case study in the plastics industry sector

This work shows the potential of the Discrete-Event Simulation -DES- in a software modeling process applied to business decision making, using a descriptive methodology in a productive process of a manufacturing plastic bags company. The analysis identified the process characteristics and built a simulated model in Arena® software. Simulation shown variability in the process greater than 50% in the cycle time, which negatively affects the economic interests of the company, impacting opportunities to supply the market risking its position with other companies in the sector. The method implemented in the present work allows to know the critical points of the process, evaluate them and project a path to obtain the optimal or most viable solution, and propose modifications rising up the probability of success of any improvement plan. This makes any economic investment or locative change a desition-making quantitative supported

Continuous improvement integrating technological tools to assertively accelerate decision-making of logistics. Case implemented in a construction materials supplier company

Considering that many of the logistics infrastructure designs around the world are often sup-ported by studies with various computational tools, but most of these solutions are using in isolation and little understandably. Therefore, it is proposed, to develop this research based on a Logistics Reference Model, which will allow, visualize, manage and analyze the different processes and logistical scenarios of the system, with in aim to execute the best cost-benefit strategy in a company dedicated to the distribution of construction materials. By implementing this methodology, the management of the company studied was able to make the best decision for the structuring of its processes in the area of picking and dispatch. The results showed a 50% re-duction in inventory review time, equal an increase in reliability 7% that leaves the company in around location close to 85.68%; a decrease in cycle time in each order between 20% and 40% which positively impacted the customer service level. In addition, a decrease in lead times for the receipt of materials to suppliers was achieved between 15% and 30%, and a decrease in the number of warehouses, went having from 5 independent to maintain one single distribution center

Implementation of the Eclipse Process Framework Composer Tool for the Documentation of Quality Management Systems: A Case Applied in Healthcare Services

This document presents the implementation of the Eclipse Process Framework Composer EPFC tool, in a company in the health sector, which where it were using physical documentation to register the processes QMS Quality Management Systems, in this one it is explained the process of adapting the tool, to migrate the documentary structure of the company, through the application of a model that correlates the attributes of the tool with the documentary structure. The proposed model allows the construction of document structures for the QMS that guide the user in their processes and procedures within the organization. Therefore, it is proposed that by promoting knowledge management and reducing the execution time of the processes, it will be possible for companies to be more productive, improve customer service, failure rates in the development of activities be minimized and, and reduces the lead time in the processes. Finally, it was obtained a documentary platform developed under a process approach that implements interactive diagrams that aim to facilitate the understanding of each of the elements that make up the QMS

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its ‘Minimal Information for Studies of Extracellular Vesicles’, which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele. © 2022, The Author(s)

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele