Supporting people with active and advanced disease: a rapid review of the evidence

1.1 Background: the NCSI AAD group The National Cancer Survivorship Initiative (NCSI, 2010) was set up in response to the NHS Cancer Reform Strategy (Department of Health, 2007) as a collaboration between Macmillan Cancer Support, the Department of Health and NHS Improvement, with the goal to achieve a better understanding of the experiences of cancer survivors and to advocate for the provision of services to support them. Within this broad remit, it was recognised that there was a particular group of patients whose needs were commonly neglected; people who were experiencing the ongoing effects of cancer beyond first-line treatment but who were not at end of life. The Active and Advanced Disease (AAD) working group was created to consider issues of relevance to such people. 1.2 Aims of this review This project set out to meet the following aim: To review the literature on selected cancers in order to identify implications for the development of services to support patients experiencing difficulties associated with active and advanced disease

Stresses in a plate having a relatively small circular hole and loaded parallel to the axis of the hole under various conditions of constraint with an application to deep oil wells

The object of this investigation is to determine the stresses about a hole in a thick plate of large dimensions compared with the radius of the hole when the plate is loaded parallel to the axis of the hole under various conditions of restraint, and to apply the results to the case of a deep well. The case of a plate with an initial stress in its plane is also considered...The problem arose from difficulties encountered in the drilling of deep oil wells. After drilling has proceeded to a certain depth, the sides of the bore hole apparently collapse and fill up the hole, resulting not only in wasted time and effort but in the loss of the drill bits. By considering the region around the well as a thick plate of dimensions very large compared to the radius of the bore hole, the conditions will be seen to correspond to one of the cases investigated. Part III of this thesis is devoted to application of the results of the general investigation carried out in parts I and II to the special problem of stresses about a deep well and the causes of the failures described above. All the cases investigated do not apply to deep wells, but it was felt that a complete investigation of the general problem might find application in other fields and would enhance the value of this thesis --Introduction, page 1-2

Effects of network topology on the OpenAnswer’s Bayesian model of peer assessment

The paper investigates if and how the topology of the peer assessment network can affect the performance of the Bayesian model adopted in Ope nAnswer. Performance is evaluated in terms of the comparison of predicted grades with actual teacher’s grades. The global network is built by interconnecting smaller subnetworks, one for each student, where intra subnetwork nodes represent student's characteristics, and peer assessment assignments make up inter subnetwork connections and determine evidence propagation. A possible subset of teacher graded answers is dynamically determined by suitable selec tion and stop rules. The research questions addressed are: RQ1) “does the topology (diameter) of the network negatively influence the precision of predicted grades?”̀ in the affirmative case, RQ2) “are we able to reduce the negative effects of high diameter networks through an appropriate choice of the subset of students to be corrected by the teacher?” We show that RQ1) OpenAnswer is less effective on higher diameter topologies, RQ2) this can be avoided if the subset of corrected students is chosen considering the network topology

Glenohumeral Joint Dissection: A New Protocol

Objectives: The glenohumeral joint, as a component of the shoulder girdle, is one of the most frequently injured joints of the upper extremity. Typical dissection of the glenohumeral joint does not allow an intracapsular view without sacrificing the joint capsule and surrounding structures. Methods: A dissection method is presented which reveals the internal capsule of the glenohumeral joint, the glenoid labrum, the proximal insertion of the long head of the biceps tendon, and glenohumeral joint surfaces while preserving the posterior aspect of the capsule and surrounding supportive muscles and tendons of the joint. Results: The novel dissection technique allowed for preservation of glenohumeral joint structures and consideration or reexamination of the relationships and structures. Conclusion: The authors present an alternative protocol for dissection of the glenohumeral joint that minimizes destruction of the surrounding structures while allowing visualization of the internal capsule and maintains the relationships of the surrounding supporting structures of the pectoral girdle that may be used for study at a later time. Conclusion: The authors present an alternative protocol for dissection of the glenohumeral joint that minimizes destruction of the surrounding structures while allowing visualization of the internal capsule and maintains the relationships of the surrounding supporting structures of the pectoral girdle that may be used for study at a later time

Cloud condensation nucleus (CCN) behavior of organic aerosol particles generated by atomization of water and methanol solutions

Cloud condensation nucleus (CCN) experiments were carried out for malonic acid, succinic acid, oxalacetic acid, DL-malic acid, glutaric acid, DL-glutamic acid monohydrate, and adipic acid, using both water and methanol as atomization solvents, at three operating supersaturations (0.11%, 0.21%, and 0.32%) in the Caltech three-column CCN instrument (CCNC3). Predictions of CCN behavior for five of these compounds were made using the Aerosol Diameter Dependent Equilibrium Model (ADDEM). The experiments presented here expose important considerations associated with the laboratory measurement of the CCN behavior of organic compounds. Choice of atomization solvent results in significant differences in CCN activation for some of the compounds studied, which could result from residual solvent, particle morphology differences, and chemical reactions between the particle and gas phases. Also, significant changes in aerosol size distribution occurred after classification in a differential mobility analyzer (DMA) for malonic acid and glutaric acid. Filter analysis of adipic acid atomized from methanol solution indicates that gas-particle phase reactions may have taken place after atomization and before the methanol was removed from the sample gas stream. Careful consideration of these experimental issues is necessary for successful design and interpretation of laboratory CCN measurements

Effects of continuing professional development on group work practices in Scottish primary schools

This study investigated the effects of a continuing professional development (CPD) initiative that provided collaborative group work skills training for primary school teachers. The study collected data from 24 primary school classrooms in different schools in a variety of urban and rural settings. The sample was composed of 332 pupils aged 9-12 years old, and 24 primary school teachers. Results indicated the CPD initiative had a significant impact on the attainment of pupils in science. In addition data indicated that the CPD promoted effective discourse and pupil dialogue during science lessons. Pre-post test observation scores were significantly different in terms of children giving of suggestions or courses of actions, offering of explanations, and telling someone to say something or carry out an action . Increases in effective dialogue were significantly correlated to increased science attainment and teacher evaluations of the impact of the CPD were positive. Significant correlations were found between teacher evaluation of impact upon pupil learning and increased attainment in science. The design and structure of CPD initiatives and the implications for practice, policy and future research are explored

New and extended parameterization of the thermodynamic model AIOMFAC: calculation of activity coefficients for organic-inorganic mixtures containing carboxyl, hydroxyl, carbonyl, ether, ester, alkenyl, alkyl, and aromatic functional groups

We present a new and considerably extended parameterization of the thermodynamic activity coefficient model AIOMFAC (Aerosol Inorganic-Organic Mixtures Functional groups Activity Coefficients) at room temperature. AIOMFAC combines a Pitzer-like electrolyte solution model with a UNIFAC-based group-contribution approach and explicitly accounts for interactions between organic functional groups and inorganic ions. Such interactions constitute the salt-effect, may cause liquid-liquid phase separation, and affect the gas-particle partitioning of aerosols. The previous AIOMFAC version was parameterized for alkyl and hydroxyl functional groups of alcohols and polyols. With the goal to describe a wide variety of organic compounds found in atmospheric aerosols, we extend here the parameterization of AIOMFAC to include the functional groups carboxyl, hydroxyl, ketone, aldehyde, ether, ester, alkenyl, alkyl, aromatic carbon-alcohol, and aromatic hydrocarbon. Thermodynamic equilibrium data of organic-inorganic systems from the literature are critically assessed and complemented with new measurements to establish a comprehensive database. The database is used to determine simultaneously the AIOMFAC parameters describing interactions of organic functional groups with the ions H^+, Li^+, Na^+, K^+, NH_(4)^+, Mg^(2+), Ca^(2+), Cl^−, Br^−, NO_(3)^−, HSO_(4)^−, and SO_(4)^(2−). Detailed descriptions of different types of thermodynamic data, such as vapor-liquid, solid-liquid, and liquid-liquid equilibria, and their use for the model parameterization are provided. Issues regarding deficiencies of the database, types and uncertainties of experimental data, and limitations of the model, are discussed. The challenging parameter optimization problem is solved with a novel combination of powerful global minimization algorithms. A number of exemplary calculations for systems containing atmospherically relevant aerosol components are shown. Amongst others, we discuss aqueous mixtures of ammonium sulfate with dicarboxylic acids and with levoglucosan. Overall, the new parameterization of AIOMFAC agrees well with a large number of experimental datasets. However, due to various reasons, for certain mixtures important deviations can occur. The new parameterization makes AIOMFAC a versatile thermodynamic tool. It enables the calculation of activity coefficients of thousands of different organic compounds in organic-inorganic mixtures of numerous components. Models based on AIOMFAC can be used to compute deliquescence relative humidities, liquid-liquid phase separations, and gas-particle partitioning of multicomponent mixtures of relevance for atmospheric chemistry or in other scientific fields

Interactions of asbestos-activated macrophages with an experimental fibrosarcoma

Supernatants from in vivo asbestos-activated macrophages failed to show any cytostatic activity against a syngeneic fibrosarcoma cell line in vitro. UICC chrysotile-induced peritoneal exudate cells also failed to demonstrate any growth inhibitory effect on the same cells in Winn assays of tumor growth. Mixing UICC crocidolite with inoculated tumor cells resulted in a dose-dependent inhibition of tumor growth; this could, however, be explained by a direct cytostatic effect on the tumor cells of high doses of crocidolite, which was observed in vitro