Breaking convention: a seismic shift in psychedelia

The latest collection of essays from the cutting edge of psychedelic research, based on talks given by their authors at Breaking Convention 2019, held at The University of Greenwich, London. The largest symposium of its kind, Breaking Convention features more than 120 academic presentations biennially, and is widely regarded as the foremost global platform for serious research into psychedelic science and culture. Within these pages are essays demonstrating a shift in psychedelia. Topics include sustainability, death, the shadow, archetypes, conservation, history, phenomenology, war, power, madness, and the marriage of energy and matter. An eclectic collection that reflects the diverse array of speakers that present at Breaking Convention, and echoes the shifts currently occurring in psychedelia: a build up of tension before new ground is created

Land use change effects on extreme flood in the Kelantan basin using hydrological model

Land use and land cover (LULC) change results in increased of flood frequency and severity. The increase of annual runoff which is caused by urban development, heavy deforestation, or other anthropogenic activities occurs within the catchment areas. Therefore, accurate and continuous LULC change information is vital in quantifying flood hydrograph for any given time. Many studies showed the effect of land use change on flood based on hydrological response (i.e., peak discharge and runoff volume). In this study, a distributed hydrological modeling and GIS approach were applied for the assessment of land use impact in the Kelantan Basin. The assessment focuses on the runoff contributions from different land use classes and the potential impact of land use changes on runoff generation. The results showed that the direct runoff from developmental area, agricultural area, and grassland region is dominant for a flood event compared with runoff from other land-covered areas in the study area. The urban areas or lower planting density areas tend to increase for runoff and for the monsoon season floods, whereas the inter-flow from forested and secondary jungle areas contributes to the normal flow

Medical theses as part of the scientific training in basic medical and dental education: experiences from Finland

<p>Abstract</p> <p>Background</p> <p>Teaching the principles of scientific research in a comprehensive way is important at medical and dental schools. In many countries medical and dental training is not complete until the candidate has presented a diploma thesis. The objective of this study was to evaluate the nature, quality, publication pattern and visibility of Finnish medical diploma theses.</p> <p>Methods</p> <p>A total of 256 diploma theses presented at the University of Oulu from 2001 to 2003 were analysed. Using a standardised questionnaire, we extracted several characteristics from each thesis. We used the name of the student to assess whether the thesis resulted in a scientific publication indexed in medical article databases. The number of citations received by each published thesis was also recorded.</p> <p>Results</p> <p>A high proportion of the theses (69.5%) were essentially statistical in character, often combined with an extensive literature review or the development of a laboratory method. Most of them were supervised by clinical departments (55.9%). Only 61 theses (23.8%) had been published in indexed scientific journals. Theses in the fields of biomedicine and diagnostics were published in more widely cited journals. The median number of citations received per year was 2.7 and the range from 0 to 14.7.</p> <p>Conclusion</p> <p>The theses were seldom written according to the principles of scientific communication and the proportion of actually published was small. The visibility of these theses and their dissemination to the scientific community should be improved.</p

Effect of Topical Anaesthetics on Interstitial Colloid Osmotic Pressure in Human Subcutaneous Tissue Sampled by Wick Technique

To measure colloid osmotic pressure in interstitial fluid (COP(i)) from human subcutaneous tissue with the modified wick technique in order to determine influence of topical application of anaesthetics, dry vs. wet wick and implantation time on COP(i).In 50 healthy volunteers interstitial fluid (IF) was collected by subcutaneous implantation of multi-filamentous nylon wicks. Study subjects were allocated to two groups; one for comparing COP(i) obtained from dry and saline soaked wicks, and one for comparing COP(i) from unanaesthetized skin, and skin after application of a eutectic mixture of local anaesthetic (EMLA®, Astra Zeneca) cream. IF was sampled from the skin of the shoulders, and implantation time was 30, 60, 75, 90 and 120 min. Colloid osmotic pressure was measured with a colloid osmometer. Pain assessment during the procedure was compared for EMLA cream and no topical anaesthesia using a visual analogue scale (VAS) in a subgroup of 10 subjects.There were no significant differences between COP(i) obtained from dry compared to wet wicks, except that the values after 75 and 90 min. were somewhat higher for the dry wicks. Topical anaesthesia with EMLA cream did not affect COP(i) values. COP(i) decreased from 30 to 75 min. of implantation (23.2 ± 4.4 mmHg to 19.6 ± 2.9 mmHg, p = 0.008) and subsequently tended to increase until 120 min. EMLA cream resulted in significant lower VAS score for the procedure.COP(i) from subcutaneous tissue was easily obtained and fluid harvesting was well tolerated when topical anaesthetic was used. The difference in COP(i) assessed by dry and wet wicks between 75 min. and 90 min. of implantation was in accordance with previous reports. The use of topical analgesia did not influence COP(i) and topical analgesia may make the wick technique more acceptable for subjects who dislike technical procedures, including children.ClinicalTrials.gov NCT01044979

FTIR spectra and absorbances of mantle orthopyroxene from Ritter, West Bismarck island arc

Data are average infrared absorbances, H2O contents and spectra for arc mantle orthopyroxene from Ritter peridotite xenoliths, West Bismarck island arc. Also included are spectra extracted from a profile across a zoned orthopyroxene from an individual sample

Solubility of water in peridotite liquids and the prevalence of steam atmospheres on rocky planets

Atmospheres are products of time-integrated mass exchange between the surface of a planet and its interior. On Earth and other planetary bodies, magma oceans likely marked significant atmosphere-forming events, during which both steam- and carbon-rich atmospheres may have been generated. However, the nature of Earth's early atmosphere, and those around other rocky planets, remains unclear for lack of constraints on the solubility of water in liquids of appropriate composition. Here we determine the solubility of water in 14 peridotite liquids, representative of Earth's mantle, synthesised in a laser-heated aerodynamic levitation furnace. We explore oxygen fugacities (fO2) between −1.9 and +6.0 log units relative to the iron-wüstite buffer at constant temperature (2173 ± 50 K) and total pressure (1 bar). The resulting fH2O ranged from nominally 0 to 0.027 bar and fH2 from 0 to 0.064 bar. Total H2O contents were determined by transmission FTIR spectroscopy of doubly-polished thick sections from the intensity of the absorption band at 3550 cm−1 and applying the Beer-Lambert law. The mole fraction of water in the liquid is found to be proportional to (fH2O)0.5, attesting to its dissolution as OH. The data are fitted by a solubility coefficient of 524 ± 16 ppmw/bar0.5, given a molar absorption coefficient, Ɛ3550, of 6.3 ± 0.3 m2/mol for basaltic glasses or 647 ± 25 ppmw/bar0.5, for a preliminary Ɛ3550 = 5.1 ± 0.3 m2/mol for peridotitic glasses. These solubility constants are roughly 10 - 25% lower than those for basaltic liquids at 1623 K and 1 bar. Higher temperatures result in lower water solubility in silicate melts, wholly offsetting the greater depolymerisation of peridotite melts that would otherwise increase H2O solubility relative to basaltic liquids at constant temperature. Because the solubility of water remains high relative to that of CO2, steam atmospheres are rare, although they may form under moderately oxidising conditions on telluric bodies, provided sufficiently high H/C ratios prevail.ISSN:0012-821XISSN:1385-013

Oxygen isotope (δ18O, Δ′17O) insights into continental mantle evolution since the Archean

Oxygen isotopic ratios are largely homogenous in the bulk of Earth’s mantle but are strongly fractionated near the Earth’s surface, thus these are robust indicators of recycling of surface materials to the mantle. Here we document a subtle but significant ~0.2‰ temporal decrease in δ18O in the shallowest continental lithospheric mantle since the Archean, no change in Δ′17O is observed. Younger samples document a decrease and greater heterogeneity of δ18O due to the development and progression of plate tectonics and subduction. We posit that δ18O in the oldest Archean samples provides the best δ18O estimate for the Earth of 5.37‰ for olivine and 5.57‰ for bulk peridotite, values that are comparable to lunar rocks as the moon did not have plate tectonics. Given the large volume of the continental lithospheric mantle, even small decreases in its δ18O may explain the increasing δ18O of the continental crust since oxygen is progressively redistributed by fluids between these reservoirs via high-δ18O sediment accretion and low-δ18O mantle in subduction zones.ISSN:2041-172