A metodoloxía para o estudio, o ensino e a investigación científica en frei Martín Sarmiento (1695-1772)

[Resumo] No presente artigo, faise unha caracterización de frei Martín Sarmiento como un sabio da ilus- tración galega, española e europea, analizando a súa metodoloxía científica á luz da ciencia moderna e dun traballo previo de investigación da súa obra.[Abstract] This paper describes Father Martin Sarmiento as an savant of the Galician, Spanish and European Enlightenment, and analyzes his scientific methodology according to modern science and pre- vious research of his work

Line Broadening and Decoherence of Electron Spins in Phosphorus-Doped Silicon Due to Environmental 29^Si Nuclear Spins

Phosphorus-doped silicon single crystals with 0.19 % <= f <= 99.2 %, where f is the concentration of 29^Si isotopes, are measured at 8 K using a pulsed electron spin resonance technique, thereby the effect of environmental 29^Si nuclear spins on the donor electron spin is systematically studied. The linewidth as a function of f shows a good agreement with theoretical analysis. We also report the phase memory time T_M of the donor electron spin dependent on both f and the crystal axis relative to the external magnetic field.Comment: 5 pages, 4 figure

Host isotope mass effects on the hyperfine interaction of group-V donors in silicon

The effects of host isotope mass on the hyperfine interaction of group-V donors in silicon are revealed by pulsed electron nuclear double resonance (ENDOR) spectroscopy of isotopically engineered Si single crystals. Each of the hyperfine-split P-31, As-75, Sb-121, Sb-123, and Bi-209 ENDOR lines splits further into multiple components, whose relative intensities accurately match the statistical likelihood of the nine possible average Si masses in the four nearest-neighbor sites due to random occupation by the three stable isotopes Si-28, Si-29, and Si-30. Further investigation with P-31 donors shows that the resolved ENDOR components shift linearly with the bulk-averaged Si mass.Comment: 5 pages, 4 figures, 1 tabl

“Who Cares?”: the acceptance of decentralized wastewater systems in regions without water problems

There is a growing interest in decentralized wastewater treatment systems, especially in regions with water scarcity problems or water management issues. This study aims to determine whether the perceived advantages and disadvantages (leading to acceptance) of decentralized wastewater plants in such regions are the same in regions where the population is not aware of these water issues. Firstly, this study systematically reviews previous findings on public perceptions of the acceptance of decentralized wastewater treatment systems. Then, the study details the results of a focus group study to determine whether the elements identified in the literature are also relevant in a region where people are unaware of water problems. The results show that a lack of awareness of water issues seems to be a critical factor influencing acceptance. Reframing the usefulness of these systems by focusing on other aspects, such as environmental sustainability, is key.info:eu-repo/semantics/publishedVersio

Glucocorticoids prime the inflammatory response of human hippocampal cells through up-regulation of inflammatory pathways

Increased pro-inflammatory cytokines and an overactive hypothalamic-pituitary-adrenal (HPA) axis have both been implicated in the pathogenesis of depression. However, these explanations appear contradictory because glucocorticoids are well recognised for their anti-inflammatory effects. Two hypotheses exist to resolve this paradox: the mediating presence of glucocorticoid receptor resistance, or the possibility that glucocorticoids can potentiate inflammatory processes in some circumstances. We sought to investigate these hypotheses in a cell model with significant relevance to depression: human hippocampal progenitor cells. We demonstrated that dexamethasone in vitro given for 24 hours and followed by a 24 hours rest interval before an immune challenge potentiates inflammatory effects in these neural cells, that is, increases the IL-6 protein secretion induced by stimulation with IL-1\u3b2 (10 ng/mL for 24 hours) by + 49% (P &lt; 0.05) at a concentration of 100 nM and by + 70% (P &lt; 0.01) for 1 \u3bcM. These effects are time- and dose-dependent and require activation of the glucocorticoid receptor. Gene expression microarray assays using Human Gene 2.1st Array Strips demonstrated that glucocorticoid treatment up-regulated several innate immune genes, including chemokines and Nod-like receptor, NLRP6; using transcription factor binding motifs we found limited evidence that glucocorticoid resistance was induced in the cells. Our data suggests a mechanism by which stress may prime the immune system for increased inflammation and suggests that stress and inflammation may be synergistic in the pathogenesis of depression

Epidemiology of gastrointestinal cancers in the hospital of Tambohobe Fianarantsoa, Madagascar

Background: Gastrointestinal cancers are among the top 10 cancers and causes of cancer death worldwide. Given the absence of cancer registry in Madagascar and absence of epidemiological study of gastrointestinal cancer in the province of Fianarantsoa, our aim was to describe the epidemiological aspect of gastrointestinal cancers at the University Hospital of Tambohobe Fianarantsoa.Methods: Authors have conducted a descriptive retrospective study over a three-year period from January 1, 2015 to December 31, 2017 at the University Hospital of Tambohobe Fianarantsoa (in oncology, internal medicine and visceral surgery departments). The variables analyzed were age, gender, tumor location.Results: Authors have collected 74 cases of gastrointestinal cancers. There were 46 males 62.16% and 28 females 37.84%. The mean age was 56.30±12.10 years old. The predominant age groups were 45-55 years. Authors found colorectal cancer in 43%, followed by liver carcinoma in 19%, then pancreatic cancer 14%, esophageal cancer 13%, gastric cancer 8%, duodenum cancer 3%.Conclusions: Gastrointestinal cancers at the hospital of Tambohobe Fianarantsoa affect young people, especially the male gender with a predominance of colorectal and liver cancer.So, it is important to continue the vaccination against hepatitis viral B infection and to implement a colorectal cancer screening program