Taylor approximations of operator functions

This survey on approximations of perturbed operator functions addresses recent advances and some of the successful methods.Comment: 12 page

The Birman-Schwinger principle in von Neumann algebras of finite type

We introduce a relative index for a pair of dissipative operators in a von Neumann algebra of finite type and prove an analog of the Birman-Schwinger principle in this setting. As an application of this result, revisiting the Birman-Krein formula in the abstract scattering theory, we represent the de la Harpe-Skandalis determinant of the characteristic function of dissipative operators in the algebra in terms of the relative index

Upconverting nanoparticles as primary thermometers and power sensors

Luminescence thermometry is a spectroscopic technique for remote temperature detection based on the thermal dependence of the luminescence of phosphors, presenting numerous applications ranging from biosciences to engineering. In this work, we use the Er3+ emission of the NaGdF4/NaGdF4:Yb3+,Er3+/NaGdF4 upconverting nanoparticles upon 980 nm laser excitation to determine simultaneously the absolute temperature and the excitation power density. The Er3+ 2H11/2→4 I15/2 and 4 S3/2→4 I15/2 emission bands, which are commonly used for thermometric purposes, overlap with the 2 H9/2 →4 I13/2 emission band, which can lead to erroneous temperature readout. Applying the concept of luminescent primary thermometry to resolve the overlapping Er3+ transitions, a dual nanosensor synchronously measuring the temperature and the delivered laser pump power is successfully realized holding promising applications in laser-supported thermal therapies.publishe

Influence of Diazepino [1,2-a] benzimidazole derivative (DAB-19) on behavioral aspects of animals

In the present study, compound DAB-19 was screened for its influence on animals` behavior patterns, such as aggression, obsessive-compulsive behavior, emotional lability, and unsociabilit

Thrombodynamics Test in Assessing the Risk of Thrombus Formation in Patients with Atrial Fibrillation Taking Direct Oral Anticoagulants

Aim. To evaluate thrombus characteristics in patients with atrial fibrillation (AF) taking different direct oral anticoagulants (DOACs) using Thrombodynamics test.Materials and methods. Thrombodynamics test was performed in 100 patients with paroxysmal and permanent forms of AF taking different DOACs, dose choice was done in accordance with the instructions for drugs use. For analysis samples of fresh citrated platelet-free plasma were taken just before regular DOACs dose intake (trough concentration). Statistical data processing was carried out using R software packages.Results. All patients had no history of thrombosis or bleeding before inclusion in this study. All parameters of Thrombodynamics test taken at residual concentration of DOACs were in general within reference values, that is in the area of normal coagulation: spatial clot growth rate (V) – 26.56 (25.0; 29.2) μm/min, the time to the start of clot growth (Tlag) – 1.05 (0.85; 1.27) min, initial spatial clot growth rate (Vi) – 44.3±7.7 μm/min, stationary spatial clot growth rate (Vst) – 26.5 (24.9; 28.4) μm/min, clot size (CS) – 999.7 (912.9; 1084.7) μm, clot density (D) – 22883.1±3199.9 arb. units. D was appeared to be higher in women [22947.7 (21477.5; 22947.7) vs men [22124.8 (19722.8; 22124.8), p=0.035] and Tlag was significantly higher in patients with chronic heart failure [1.2 (1.0; 1.2) vs 1.0 (0.8; 1.0), p=0.008]. A correlation was found between level of creatinine and Tlag parameter, glomerular filtration rate (GFR) and clot density. With an increase in the level of creatinine in the blood and a decrease in GFR, respectively, there was an increase in Tlag parameter (p-value 0.038); with an increase in GFR, clot density decrease (p-value 0.005).Conclusion. All parameters of Thrombodynamics test on residual concentration of DOACs were within reference values that indicated optimal anticoagulant effect of all DOACs. The obtained data of normal coagulation at the residual concentration of the anticoagulant are consistent with the previously obtained data on the safety and effectiveness of DOACs using other methods. Further studies with clinical end points are needed to assess the clinical value of this method

Screening of anxiolytic properties and analysis of structure-activity relationship of new derivatives of 6-(4-methoxy)-7H-[1,2,4] triazolo [3,4-a] [2,3] benzodiazepine under the code RD

Anxiolytic potential and cytotoxic properties of previously synthesized molecules, containing fragments of 2,3-benzodiazepine and 1,2,4-triazole - 6-(4-methoxyphenyl)-7H-[1,2,4] triazolo [3,4-A] [2,3]benzodiazepines under the generic code RD were studie

The technical asprcts of building station for the accreditation of the pharmacists at the department of management and economics of pharmasy ural state medical university

Key elements of the stations of the second stage of the initial accreditation pharmacists and equipping stations.В статье рассмотрены ключевые элементы станций второго этапа первичной аккредитации провизоров и оснащение станций