A REVIEW ON REHEATED COOKING OIL AS AN ASPECT OF SANSKAR VIRUDDHA

Ayurveda is a science of life. Ayurveda focuses more to remain healthy and prevent diseases. To become healthy, diet plays a very important role. All the Ayurvedic classics have paid special attention on the concept of wholesome and unwholesome diet. The food, which maintains the balanced Dhatus in normalcy and restores the equilibrium, should be taken as wholesome. Unwholesome diet i.e. Viruddha Ahara is a special concept described in Ayurvedic literature. Different types of Viruddha’s have been mentioned according to place, time, digestion power, dosage, habit, doshas, mode of preparation and so on. Samskar Viruddha is that where food is converted into harmful substances during the course of preparation emerging ill effects on health. In current scenario examples of Samskar Viruddha Ahara are being changed due to changing life style, urbanization and fascination of western culture. Though there is noticeable change in food habits and preparatory methods between early time and in present era, the principle (Ayurvedic siddhant) behind this remained the same. Today’s lifestyle is very fast, full of hurry. As a result consumption of ready-made food is in much demand. And if it is deep-fried then its demand becomes even higher. Edible vegetable oil is the major ingredient in these fried food products. Reusing this deep fried oil repeatedly for frying purposes leads to many health hazards. The efforts have been made here to elaborate health effects of reusing cooking oil for frying process as an account of Samskar Viruddha. 

SOLID DISPERSION: A NOVEL APPROACH FOR POORLY WATER SOLUBLE DRUGS

Objective: Out of newly discovered drugs more than 40% pharmacologically active molecule having poor solubility. This is one of the serious challenge in the pharmaceutical industry and commercialization of the drug. Methods: With the introduction of new manufacturing technologies such as solid dispersion pH modification, SEED, salt formation, co crystallization. Results: it should be possible to overcome problems. Potential of solid dispersion technology has been well established for hydrophobic agents because of ease of optimization, simplicity and easy scale up. Conclusion: This article begins with an overview of the historical background and definition and importance of solubility and solid dispersion. The remainder of the article is devoted to the production, the different carriers and the methods used for the characterization of solid dispersions

A ternary PEDOT-TiO2-reduced graphene oxide nanocomposite for supercapacitor applications

A ternary composite of PEDOT was prepared with TiO2 via emulsion polymerization method adjusting various weight ratios of TiO2 to PEDOT and synthesized rGO was then blended with this composite. The FTIR, UV–Vis and XRD analysis displayed characteristic features of PEDOT and TiO2. The morphology of the nano-hybrid structure was additionally investigated by SEM analysis. Pore size and surface area analysis of particles were characterized by BET method. The electrochemical analysis showed that the specific capacitance (Csp) for PEDOT-TiO2-15-rGO was 18.9 F.cm-2 at 0.1 mA g-1 current density

Fructan and its relationship to abiotic stress tolerance in plants

Numerous studies have been published that attempted to correlate fructan concentrations with freezing and drought tolerance. Studies investigating the effect of fructan on liposomes indicated that a direct interaction between membranes and fructan was possible. This new area of research began to move fructan and its association with stress beyond mere correlation by confirming that fructan has the capacity to stabilize membranes during drying by inserting at least part of the polysaccharide into the lipid headgroup region of the membrane. This helps prevent leakage when water is removed from the system either during freezing or drought. When plants were transformed with the ability to synthesize fructan, a concomitant increase in drought and/or freezing tolerance was confirmed. These experiments indicate that besides an indirect effect of supplying tissues with hexose sugars, fructan has a direct protective effect that can be demonstrated by both model systems and genetic transformation

Twelve-month observational study of children with cancer in 41 countries during the COVID-19 pandemic

Introduction Childhood cancer is a leading cause of death. It is unclear whether the COVID-19 pandemic has impacted childhood cancer mortality. In this study, we aimed to establish all-cause mortality rates for childhood cancers during the COVID-19 pandemic and determine the factors associated with mortality. Methods Prospective cohort study in 109 institutions in 41 countries. Inclusion criteria: children <18 years who were newly diagnosed with or undergoing active treatment for acute lymphoblastic leukaemia, non-Hodgkin's lymphoma, Hodgkin lymphoma, retinoblastoma, Wilms tumour, glioma, osteosarcoma, Ewing sarcoma, rhabdomyosarcoma, medulloblastoma and neuroblastoma. Of 2327 cases, 2118 patients were included in the study. The primary outcome measure was all-cause mortality at 30 days, 90 days and 12 months. Results All-cause mortality was 3.4% (n=71/2084) at 30-day follow-up, 5.7% (n=113/1969) at 90-day follow-up and 13.0% (n=206/1581) at 12-month follow-up. The median time from diagnosis to multidisciplinary team (MDT) plan was longest in low-income countries (7 days, IQR 3-11). Multivariable analysis revealed several factors associated with 12-month mortality, including low-income (OR 6.99 (95% CI 2.49 to 19.68); p<0.001), lower middle income (OR 3.32 (95% CI 1.96 to 5.61); p<0.001) and upper middle income (OR 3.49 (95% CI 2.02 to 6.03); p<0.001) country status and chemotherapy (OR 0.55 (95% CI 0.36 to 0.86); p=0.008) and immunotherapy (OR 0.27 (95% CI 0.08 to 0.91); p=0.035) within 30 days from MDT plan. Multivariable analysis revealed laboratory-confirmed SARS-CoV-2 infection (OR 5.33 (95% CI 1.19 to 23.84); p=0.029) was associated with 30-day mortality. Conclusions Children with cancer are more likely to die within 30 days if infected with SARS-CoV-2. However, timely treatment reduced odds of death. This report provides crucial information to balance the benefits of providing anticancer therapy against the risks of SARS-CoV-2 infection in children with cancer

Site Suitability Analysis For Watershed Structures In Khokar Nala By Using Remote Sensing And Gis

Water is a key component in determining the quality of our lives. Watershed is a natural hydrological unit. Watershed approach is holistic, linking upstream and downstream area. In KHOKAR NALA drainage basin, degradation rate is increasing and depletion of resources is occurred. There is loss of productive soil. Also there is reduced carrying capacity of streams. In present study, potential sites for watershed structure in KHOKAR NALA basin of Ahmednagar district, Maharashtra, India have been identified by using remote sensing and GIS techniques. Various thematic maps such as Land use/land cover, stream order, slope etc. are prepared using remote sensing application. The remote sensing data is operationally being utilized for mapping various resources. The need is to step ahead towards integrating these resources maps with their resources information and other socioeconomic data for general action plan. GIS can be used to manipulation of data, product generation, data management and data retrieval, etc. Remote sensing gives timely and accurate information on spatial distribution- land use, soil vegetation density, forest, geology water resources. The final map showing different categories of suitability sites for water harvesting structure such as Check dams, percolation tanks, farm ponds, contour bunding, and contour trenching have been suggested

Mechanisms of potentiation by calcium-calmodulin kinase II of postsynaptic sensitivity in rat hippocampal CA1 neurons

Mechanisms of potentiation by calcium-calmodulin kinase II of postsynaptic sensitivity in rat hippocampal CA1 neurons. J. Neurophysiol. 78: 2682-2692, 1997. Preactivated recombinant alpha-calcium-calmodulin dependent multifunctional protein kinase II (CaMKII*) was perfused internally into CA1 hippocampal slice neurons to test the effect on synaptic transmission and responses to exogenous application of glutamate analogues. After measurement of baseline transmission, internal perfusion of CaMKII* increased synaptic strength in rat hippocampal neurons and diminished the fraction of synaptic failures. After measurement of baseline responses to applied transmitter, CaMKII* perfusion potentiated responses to kainate but not responses to N-methyl--aspartate. Internal perfusion of CaMKII*potentiated the maximal effect of kainate. Potentiation by CaMKII* did not change the time course of responses to kainate, whereas increasing response size by pharmacologically manipulating desensitization or deactivation rate constants significantly altered the time course of responses. Nonstationary fluctuation analysis of responses to kainate showed a decrease in the coefficient of variation after potentiation by CaMKII*. These data support the hypothesis that CaMKII increases postsynaptic responsiveness by increasing the available number of active alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid/kainate channels and suggests that a similar process may occur during the expression of long-term potentiation