Objective: Out of newly discovered drugs more than 40% pharmacologically active molecule having poor solubility. This is one of the serious challenge in the pharmaceutical industry and commercialization of the drug.
Methods: With the introduction of new manufacturing technologies such as solid dispersion pH modification, SEED, salt formation, co crystallization.
Results: it should be possible to overcome problems. Potential of solid dispersion technology has been well established for hydrophobic agents because of ease of optimization, simplicity and easy scale up.
Conclusion: This article begins with an overview of the historical background and definition and importance of solubility and solid dispersion. The remainder of the article is devoted to the production, the different carriers and the methods used for the characterization of solid dispersions
