Time-frequency analysis of 3D ship-wave fields in martime waterways

In the last 15 years an increased number of serious damages of protective structures such as groins and revetments have been observed in maritime waterways. The analyses of these damages have shown that the current design approaches for the rubble mound layers of such structures are not sufficient to ensure sufficient stability against ship-induced wave loads. Since these approaches are determined for wind-induced waves, they do not consider the long-period ship-wave components. Within a joint research project, the design loads of ship-induced long-period waves on rubble mound structures in maritime waterways are investigated. By means of first project results, the knowledge gaps with respect to the classification and parameterization of ship waves have been identified. The project has clearly shown the need for a 3D analysis of three-dimensional, nonlinear ship-wave fields. Therefore, another research project was initiated in order to generate the scientific knowledge for the parameterization of ship-induced 3D wave fields as required for the hydraulic design of rubble mound structures in maritime waterways with a special focus on the spatial and nonlinear properties of ship waves

N-(3-Chloro­benzo­yl)-2-nitro­benzene­sulfonamide

In the title compound, C13H9ClN2O5S, the N—C bond in the C—SO2—NH—C segment has a gauche torsion with respect to the S=O bonds. The conformation between the N—H bond and the ortho-nitro group in the sulfonyl benzene ring is syn, and that between the C=O and the meta-Cl atom in the benzoyl ring is anti. The mol­ecule is twisted at the S—N bond, with a torsion angle of 65.41 (38)°. The dihedral angle between the sulfonyl benzene ring and the –SO2—NH—C—O segment is 75.0 (1)°, and that between the sulfonyl and the benzoyl benzene ring is 89.1 (1)°. The crystal structure features inversion-related dimers linked by pairs of N—H⋯O(S) hydrogen bonds

Maximizing detection of dengue virus serotypes by a modified reverse transcription-polymerase chain reaction assay in India: presence of co-infection with multiple serotypes

n/

Smart Battery Management System for Electric Vehicles

Electric vehicles are showing some promises in the automotive industry and can be the answer for mitigating carbon footprint. In the process of upgrading electric vehicles to the customer demands, battery performance serves a crucial part in deciding the performance of the electric vehicles. So, Battery Management System becomes the brains behind monitoring and controlling the battery. Real-time sensing of the battery parameters, decision-making capability to choose the type of charging, and which cell to be charged are all the functionalities of BMS. All these criteria can be assessed precisely and efficiently via processors like Raspberry pi, along with IoT and cloud computing technologies. These approaches can be used for remote accessing of the battery’s performance, which will help the customer and the company to analyse the vehicle's condition. They also help prevent battery degradation. Since IoT and cloud computing technologies are being used, if an adverse state occurs in the battery, the customer can be notified directly via their mobile. In this article, a combined technology of locally hosted processor and cloud-based decision making has been discussed to improve the battery intern Electric Vehicle’s performance

4-Chloro-N-(3-methyl­benzo­yl)benzene­sulfonamide monohydrate

In the title compound, C14H12ClNO3S·H2O, the dihedral angle between the sulfonyl and benzoyl benzene rings is 84.4 (2)°. In the crystal, every water mol­ecule forms four hydrogen bonds with three different mol­ecules of 4-chloro-N-(3-methyl­benzo­yl)benzene­sulfonamide. One of the water H atoms forms a bifurcated hydrogen bond with both the sulfonyl and the carbonyl O atoms of the same mol­ecule. Mol­ecules are linked into layers in the ab plane through N—H⋯O and O—H⋯O hydrogen bonds

Microparticle-mediated transfer of the viral receptors CAR and CD46, and the CFTR channel in a CHO cell model confers new functions to target cells

Cell microparticles (MPs) released in the extracellular milieu can embark plasma membrane and intracellular components which are specific of their cellular origin, and transfer them to target cells. The MP-mediated, cell-to-cell transfer of three human membrane glycoproteins of different degrees of complexity was investigated in the present study, using a CHO cell model system. We first tested the delivery of CAR and CD46, two monospanins which act as adenovirus receptors, to target CHO cells. CHO cells lack CAR and CD46, high affinity receptors for human adenovirus serotype 5 (HAdV5), and serotype 35 (HAdV35), respectively. We found that MPs derived from CHO cells (MP-donor cells) constitutively expressing CAR (MP-CAR) or CD46 (MP-CD46) were able to transfer CAR and CD46 to target CHO cells, and conferred selective permissiveness to HAdV5 and HAdV35. In addition, target CHO cells incubated with MP-CD46 acquired the CD46-associated function in complement regulation. We also explored the MP-mediated delivery of a dodecaspanin membrane glycoprotein, the CFTR to target CHO cells. CFTR functions as a chloride channel in human cells and is implicated in the genetic disease cystic fibrosis. Target CHO cells incubated with MPs produced by CHO cells constitutively expressing GFP-tagged CFTR (MP-GFP-CFTR) were found to gain a new cellular function, the chloride channel activity associated to CFTR. Time-course analysis of the appearance of GFP-CFTR in target cells suggested that MPs could achieve the delivery of CFTR to target cells via two mechanisms: the transfer of mature, membrane-inserted CFTR glycoprotein, and the transfer of CFTR-encoding mRNA. These results confirmed that cell-derived MPs represent a new class of promising therapeutic vehicles for the delivery of bioactive macromolecules, proteins or mRNAs, the latter exerting the desired therapeutic effect in target cells via de novo synthesis of their encoded proteins