Polarization angle accuracy for future CMB experiments. The COSMOCal project and its prototype in the 1mm band

The Cosmic Microwave Background (CMB) radiation offers a unique window into the early Universe, facilitating precise examinations of fundamental cosmological theories. However, the quest for detecting B-modes in the CMB, predicted by theoretical models of inflation, faces substantial challenges in terms of calibration and foreground modeling. The COSMOCal (COsmic Survey of Millimeter wavelengths Objects for CMB experiments Calibration) project aims at enhancing the accuracy of the absolute calibration of the polarization angle $\psi$ of current and future CMB experiments. The concept includes the build of a very well known artificial source emitting in the frequency range [20-350] GHz that would act as an absolute calibrator for several polarization facilities on Earth. A feasibility study to place the artificial source in geostationary orbit, in the far field for all the telescopes on Earth, is ongoing. In the meanwhile ongoing hardware work is dedicated to build a prototype to test the technology, the precision and the stability of the polarization recovering in the 1 mm band (220-300 GHz). High-resolution experiments as the NIKA2 camera at the IRAM 30m telescope will be deployed for such use. Once carefully calibrated ($\Delta\psi$ < 0.1 degrees) it will be used to observe astrophysical sources such as the Crab nebula, which is the best candidate in the sky for the absolute calibration of CMB experiments.Comment: to appear in Proc. of the mm Universe 2023 conference, Grenoble (France), June 2023, published by F. Mayet et al. (Eds), EPJ Web of conferences, EDP Science

The CXCL12γ Chemokine Displays Unprecedented Structural and Functional Properties that Make It a Paradigm of Chemoattractant Proteins

The CXCL12γ chemokine arises by alternative splicing from Cxcl12, an essential gene during development. This protein binds CXCR4 and displays an exceptional degree of conservation (99%) in mammals. CXCL12γ is formed by a protein core shared by all CXCL12 isoforms, extended by a highly cationic carboxy-terminal (C-ter) domain that encompass four overlapped BBXB heparan sulfate (HS)-binding motifs. We hypothesize that this unusual domain could critically determine the biological properties of CXCL12γ through its interaction to, and regulation by extracellular glycosaminoglycans (GAG) and HS in particular. By both RT-PCR and immunohistochemistry, we mapped the localization of CXCL12γ both in mouse and human tissues, where it showed discrete differential expression. As an unprecedented feature among chemokines, the secreted CXCL12γ strongly interacted with cell membrane GAG, thus remaining mostly adsorbed on the plasmatic membrane upon secretion. Affinity chromatography and surface plasmon resonance allowed us to determine for CXCL12γ one of the higher affinity for HS (Kd = 0.9 nM) ever reported for a protein. This property relies in the presence of four canonical HS-binding sites located at the C-ter domain but requires the collaboration of a HS-binding site located in the core of the protein. Interestingly, and despite reduced agonist potency on CXCR4, the sustained binding of CXCL12γ to HS enabled it to promote in vivo intraperitoneal leukocyte accumulation and angiogenesis in matrigel plugs with much higher efficiency than CXCL12α. In good agreement, mutant CXCL12γ chemokines selectively devoid of HS-binding capacity failed to promote in vivo significant cell recruitment. We conclude that CXCL12γ features unique structural and functional properties among chemokines which rely on the presence of a distinctive C-ter domain. The unsurpassed capacity to bind to HS on the extracellular matrix would make CXCL12γ the paradigm of haptotactic proteins, which regulate essential homeostatic functions by promoting directional migration and selective tissue homing of cells

Polarization angle accuracy for future CMB experiments

The Cosmic Microwave Background (CMB) radiation offers a unique window into the early Universe, facilitating precise examinations of fundamental cosmological theories. However, the quest for detecting B-modes in the CMB, predicted by theoretical models of inflation, faces substantial challenges in terms of calibration and foreground modeling. The COSMOCal (COsmic Survey of Millimeter wavelengths Objects for CMB experiments Calibration) project aims at enhancing the accuracy of the absolute calibration of the polarization angle ψ of current and future CMB experiments. The concept includes the build of a very well known artificial source emitting in the frequency range [20-350] GHz that would act as an absolute calibrator for several polarization facilities on Earth. A feasibility study to place the artificial source in geostationary orbit, in the far field for all the telescopes on Earth, is ongoing. In the meanwhile ongoing hardware work is dedicated to build a prototype to test the technology, the precision and the stability of the polarization recovering in the 1 mm band (220-300 GHz). High-resolution experiments as the NIKA2 camera at the IRAM 30m telescope will be deployed for such use. Once carefully calibrated (Δψ < 0.1◦) it will be used to observe astrophysical sources such as the Crab nebula, which is the best candidate in the sky for the absolute calibration of CMB experiments

The Management of the Human Resources and the Quality of the Services

Due to their nature and market position, service companies are committed to excellence. But to achieve excellence they must have a clear vision of their product that gives them the best competitive advantages and guides the resources of the company toward success. Human resources management is a tool that has been implemented to develop human potential; service quality depends on understanding the processes and tools that promote a positive attitude in members of an organization and a greater commitment to meeting management goals. These elements are translated into concrete actions, which can be seen in the mechanisms that ensure client satisfaction. The new information development culture is based on three elements: first, globalization, which has created a world market that is not constricted by time and space; second, a business model and opportunities based on networked economic activity; and finally, interdisciplinarity, a fundamental mechanism for managing resources. In this work, we seek to identify the factors that influence a company’s human resources management and service quality. What factors influence modern human resources management in companies facing technological and administrative changes requiring an adequate level of service quality? The content is related to human resources management, service quality, and factors that influence both areas, specifically in the case of urban transportation companies, because they are an indispensable resource for society providing a service directed at the inhabitants and tourists of the selected region. </jats:p

Information Technologies as a Vital Channel for an Internal E-Communication Strategy

The use of traditional marketing tools with the purpose to increase effectiveness and efficacy within organizations has been studied among different authors. This topic known as internal marketing (IM) starts defining employees as internal clients to whom the organization must satisfy a group of needs and expectations to achieve their engagement and motivation on work, looking forward to increased productivity and competitively within the organization. Among the most important aspects and maybe the least discussed on IM are the information technologies (IT), in first place, as a method to ease the work increasing the labor life quality (LLQ). Furthermore, the information technologies are a vital channel to develop an internal e-communication (internal electronic communication) effective strategy. In both cases, the new technologies give enormous possibilities as supporting strategies to IM, allowing the organization to have a direct and permanent relationship with its workers in any place, important aspect to have a successful integration, and participation on the global economy. The present article talks about the challenges and possibilities that offer the IT as IM support, mainly, being an important channel to the internal e-communication. </jats:p

Information Technologies as a Vital Channel for an Internal E-Communication Strategy

The use of traditional marketing tools with the purpose to increase effectiveness and efficacy within organizations has been studied among different authors. This topic known as internal marketing (IM) starts defining employees as internal clients to whom the organization must satisfy a group of needs and expectations to achieve their engagement and motivation on work, looking forward to increased productivity and competitively within the organization. Among the most important aspects and maybe the least discussed on IM are the information technologies (IT), in first place, as a method to ease the work increasing the labor life quality (LLQ). Furthermore, the information technologies are a vital channel to develop an internal e-communication (internal electronic communication) effective strategy. In both cases, the new technologies give enormous possibilities as supporting strategies to IM, allowing the organization to have a direct and permanent relationship with its workers in any place, important aspect to have a successful integration, and participation on the global economy. The present article talks about the challenges and possibilities that offer the IT as IM support, mainly, being an important channel to the internal e-communication. </jats:p

The role of three-ligament tenodesis in the treatment of chronic scapholunate instability

Restoring ligamentous control in dissociative carpal instability is a major issue in protecting against osteoarthritis. We present clinical and radiological results for 20 patients who underwent flexor carpi radialis three-ligament tenodesis and were prospectively reviewed at a mean follow-up of 25.1 months. Three-ligament tenodesis significantly relieved pain and increased grip strength, wrist function at the expense of joint stiffness. This improvement was not seen in cases of dynamic instability. However, ligamentous loosening did result in rapid recurrence of radiological anomalies and frequent complications. This study challenges the long-term benefit of three-ligament tenodesis in both dynamic and static chronic scapholunate instability. </jats:p

Low frequency radioastronomy of the inner heliosphere: the way

Item does not contain fulltext40th COSPAR Scientific Assembly, 2-10 August 2014, in Moscow, Russi