102 research outputs found
Recommended from our members
Connectivity and larval dispersal along the Oregon coast estimated by numerical simulations
Connectivity and larval dispersal is explored off the Oregon coast during the summer upwelling season of 2001 using numerical ocean circulation simulations. The study region, with strong wind-driven currents and variable topography, is modeled using the Regional Ocean Modeling System (ROMS) forced by the Coupled Ocean Atmosphere Mesoscale Prediction System. A large number of passive particles as models of planktonic larvae are released daily for 120 days from 1 May to 28 August at depths of 1, 7, 15, 20, 50, and 75 m at every grid point shoreward of the 200 m isobath (on average 32 km offshore). The particles are transported by the three-dimensional currents of the model simulation. The competency time window for larval settlement is assumed to be in between days 15 and 35 after larvae are released. Larval settlement occurs at the shallowest location during the competency time window. Connectivity matrices reveal that some of the places of highest retention are similar to the proposed Oregon marine reserve sites, especially Cape Perpetua. The Heceta Bank region has high probabilities as both a source and a destination for settled larvae. Larvae released in the Heceta Bank region often settle at higher latitudes than their release location. There are strong correlations between the number of settled larvae shallower than the 50 m isobath and a 6 to 8 day running mean of the alongshore wind stress. Larvae are retained near the shore when the winds, averaged over the previous 6 to 8 days, are relaxed or downwelling favorable.This is the publisher's final pdf. The published article is copyrighted by American Geophysical Union and can be found at: http://www.agu.org/journals/jc/index.shtm
Recommended from our members
Enhancing the Interpretive Reading and Analytical Writing of Mainstreamed English Learners in Secondary School: Results From a Randomized Field Trial Using a Cognitive Strategies Approach
In this study, 72 secondary English teachers from the Santa Ana Unified School District were randomly assigned to participate in the Pathway Project, a cognitive strategies approach to teaching interpretive reading and analytical writing, or to a control condition involving typical district training focusing on teaching content from the textbook. Pathway teachers learned how to use an on-demand writing assessment to help mainstreamed English learners understand, interpret, and write analytical essays. In Year 2, treatment effects were replicated on an on-demand writing assessment (d = .67) and showed evidence of transfer to improved performance on a standardized writing test (d = .10). The results underscore the efficacy of a cognitive strategies reading/writing intervention for mainstreamed English learners (ELs) in the secondary grades
Tropical forest soil carbon stocks do not increase despite 15 years of doubled litter inputs
peer-reviewedSoil organic carbon (SOC) dynamics represent a persisting uncertainty in our understanding of the
global carbon cycle. SOC storage is strongly linked to plant inputs via the formation of soil organic
matter, but soil geochemistry also plays a critical role. In tropical soils with rapid SOC turnover, the
association of organic matter with soil minerals is particularly important for stabilising SOC but
projected increases in tropical forest productivity could trigger feedbacks that stimulate the release of
stored SOC. Here, we demonstrate limited additional SOC storage after 13–15 years of experimentally
doubled aboveground litter inputs in a lowland tropical forest. We combined biological, physical, and
chemical methods to characterise SOC along a gradient of bioavailability. After 13 years of monthly
litter addition treatments, most of the additional SOC was readily bioavailable and we observed no
increase in mineral-associated SOC. Importantly, SOC with weak association to soil minerals declined
in response to long-term litter addition, suggesting that increased plant inputs could modify the
formation of organo-mineral complexes in tropical soils. Hence, we demonstrate the limited capacity
of tropical soils to sequester additional C inputs and provide insights into potential underlying
mechanisms
Regresión de las algas marinas en las Islas Canarias y en la costa atlántica de la Península Ibérica por efecto del cambio climático
Versión del edito
Effectiveness of Fosfomycin for the Treatment of Multidrug-Resistant Escherichia coli Bacteremic Urinary Tract Infections
IMPORTANCE The consumption of broad-spectrum drugs has increased as a consequence of the spread of multidrug-resistant (MDR) Escherichia coli. Finding alternatives for these infections is critical, for which some neglected drugs may be an option. OBJECTIVE To determine whether fosfomycin is noninferior to ceftriaxone or meropenem in the targeted treatment of bacteremic urinary tract infections (bUTIs) due to MDR E coli. DESIGN, SETTING, AND PARTICIPANTS This multicenter, randomized, pragmatic, open clinical trial was conducted at 22 Spanish hospitals from June 2014 to December 2018. Eligible participants were adult patients with bacteremic urinary tract infections due to MDR E coli; 161 of 1578 screened patients were randomized and followed up for 60 days. Data were analyzed in May 2021. INTERVENTIONS Patients were randomized 1 to 1 to receive intravenous fosfomycin disodium at 4 g every 6 hours (70 participants) or a comparator (ceftriaxone or meropenem if resistant; 73 participants) with the option to switch to oral fosfomycin trometamol for the fosfomycin group or an active oral drug or pa renteral ertapenem for the comparator group after 4 days. MAIN OUTCOMES AND MEASURES The primary outcome was clinical and microbiological cure (CMC) 5 to 7 days after finalization of treatment; a noninferiority margin of 7% was considered. RESULTS Among 143 patients in the modified intention-to-treat population (median [IQR] age, 72 [62-81] years; 73 [51.0%] women), 48 of 70 patients (68.6%) treated with fosfomycin and 57 of 73 patients (78.1%) treated with comparators reached CMC (risk difference, -9.4 percentage points; 1-sided 95% CI, -21.5 to infinity percentage points; P = .10). While clinical or microbiological failure occurred among 10 patients (14.3%) treated with fosfomycin and 14 patients (19.7%) treated with comparators (risk difference, -5.4 percentage points; 1-sided 95% CI. -infinity to 4.9; percentage points; P = .19), an increased rate of adverse event-related discontinuations occurred with fosfomycin vs comparators (6 discontinuations [8.5%] vs 0 discontinuations; P = .006). In an exploratory analysis among a subset of 38 patients who underwent rectal colonization studies, patients treated with fosfomycin acquired a new ceftriaxone-resistant or meropenem-resistant gram-negative bacteria at a decreased rate compared with patients treated with comparators (0 of 21 patients vs 4 of 17 patients [23.5%]; 1-sided P = .01). CONCLUSIONS AND RELEVANCE This study found that fosfomycin did not demonstrate noninferiority to comparators as targeted treatment of bUTI from MDR E coli; this was due to an increased rate of adverse event-related discontinuations. This finding suggests that fosfomycin may be considered for selected patients with these infections
- …