Controversies in acute kidney injury: the 2011 Brussels Roundtable

The recent advent of consensus definitions for acute kidney injury (AKI) has led to improvement in epidemiology of this complex disease and facilitated the development of new diagnostic makers and new therapies. However, important new challenges are also apparent. We still do not really understand why AKI occurs and urgently need to develop new therapies to treat it. Progress in this area will require new ideas and thinking outside the conventional box. By confronting some of the most significant controversies in the field of AKI we seek to develop new concepts that will ultimately yield new results

Chemical composition of Earth-like planets

Models of planet formation are mainly focused on the accretion and dynamical processes of the planets, neglecting their chemical composition. In this work, we calculate the condensation sequence of the different chemical elements for a low-mass protoplanetary disk around a solar-type star. We incorporate this sequence of chemical elements (refractory and volatile elements) in our semi-analytical model of planet formation which calculates the formation of a planetary system during its gaseous phase. The results of the semi-analytical model (final distributions of embryos and planetesimals) are used as initial conditions to develope N-body simulations that compute the post-oligarchic formation of terrestrial-type planets. The results of our simulations show that the chemical composition of the planets that remain in the habitable zone has similar characteristics to the chemical composition of the Earth. However, exist differences that can be associated to the dynamical environment in which they were formed.Comment: 3 pages, 4 figures - Accepted for publication in the Bolet\'in de la Asociaci\'on Argentina de Astronom\'ia, vol.5

Prison de-radicalization strategies, programs and risk assessment tools in Europe

open3noWith financial support from the Criminal Justice Programme of the European Union Call: JUST-AG-2016-03 Project Number: 763710 Project Acronym: PRP Duration (months): 24 Project Title: European Prison Observatory. Prison de-radicalization strategies, programmes and risk assessment tools in Europe. Coordinator: ANTIGONE ONLUS Alvise Sbraccia wrote the Part One of this Report; Daniela Ronco wrote Part Two, chapters 1, 2, 3, 4, 5, 6, 7, 8; Giovanni Torrente wrote Part Two, chapters 9-10. The conclusions have been written by all the authorsThis project’s goal is to assess strategies and programmes which prevent, deter and counter radicalization in prison and identify and analyse good practices regarding new or existing de-radicalization, disengagement and rehabilitation programmes and risk assessment tools. The analysis has been carried out having in mind the international and European standards for the the protection of detainees' rights. Research incorporates qualitative and quantitative data analysis on official government documents and interviews with stakeholders from prison administration and management, prison staff, Imams, chaplains and other religious representatives.openDaniela Ronco, Alvise Sbraccia, Giovanni TorrenteDaniela Ronco, Alvise Sbraccia, Giovanni Torrent

Beating noise with abstention in state estimation

We address the problem of estimating pure qubit states with non-ideal (noisy) measurements in the multiple-copy scenario, where the data consists of a number N of identically prepared qubits. We show that the average fidelity of the estimates can increase significantly if the estimation protocol allows for inconclusive answers, or abstentions. We present the optimal such protocol and compute its fidelity for a given probability of abstention. The improvement over standard estimation, without abstention, can be viewed as an effective noise reduction. These and other results are exemplified for small values of N. For asymptotically large N, we derive analytical expressions of the fidelity and the probability of abstention, and show that for a fixed fidelity gain the latter decreases with N at an exponential rate given by a Kulback-Leibler (relative) entropy. As a byproduct, we obtain an asymptotic expression in terms of this very entropy of the probability that a system of N qubits, all prepared in the same state, has a given total angular momentum. We also discuss an extreme situation where noise increases with N and where estimation with abstention provides a most significant improvement as compared to the standard approach

Development of an Approach for the Holistic Assessment of Innovation Projects in Manufacturing Including Potential, Effort, and Risk Using a Systematic Literature Review and Expert Interviews

Manufacturing companies face severe challenges from rapid technological developments. Industry 5.0 indicates the need for a sustainable, human-centered, and resilient industry. In striving for transformation, innovation becomes critical. However, a careful allocation of resources implies the evaluation of innovation projects. Moreover, diverse types of innovation and limited amounts of information represent a significant challenge. Therefore, this contribution presents an approach for holistically assessing innovation in manufacturing. First, a systematic literature review (SLR) was conducted to frame the current research state and identify assessment criteria. Second, a multiple-attribute decision-making method (MADM) was developed using the findings of the SLR and expert interviews. Finally, the criteria and the assessment approach were verified and validated by expert interviews, a workshop, and an industrial use case application. As the main findings, three criteria groups were derived and detailed: potentials, efforts, and risks. These criteria groups were used in a MADM approach incorporating Fuzzy set theory within a hybrid technique, combining the Analytical Hierarchical Process with the Technique for Order Preference by Similarity to Ideal Solutions. In conclusion, an enhancement of innovation assessment in manufacturing was achieved through the integration of different criteria and the balance between complexity and industrial applicability

Pro/con clinical debate: Is high-volume hemofiltration beneficial in the treatment of septic shock?

Although there have been exciting advances in the management of sepsis and septic shock, mortality still remains high. Recent data suggest that high-volume hemofiltration (HVHF) may play a role in these patients. In contrast to the usual rate of hemofiltration, HVHF is felt to be better able to remove the inflammatory mediators associated with sepsis and septic shock. Such an approach is currently incapable of selectively removing specific mediators. This may be a problem when one considers that several mediators may in fact be beneficial. When determining whether HVHF should be instituted in a patient with septic shock, one need remember that its role is far from clear and its usefulness remains the subject of much debate. Although early data is encouraging, it is clear that additional data is required before HVHF becomes standard management. The authors of this pro/con debate, which is based on a clinical scenario, first describe their own position and then respond to their opponent's position

Development of an OpenFOAM multiphysics solver for solid fission products transport in the Molten Salt Fast Reactor

The analysis of innovative reactor concepts such as the Molten Salt Fast Reactor (MSFR) requires the development of new modeling and simulation tools. In the case of the MSFR, the strong intrinsic coupling between thermal-hydraulics, neutronics and fuel chemistry has led to the adoption of the multiphysics approach as a state-of-the-art paradigm. One of the peculiar aspects of liquid-fuel reactors such as the MSFR is the mobility of fission products (FPs) in the reactor circuit. Some FP species appear in form of solid precipitates carried by the fuel flow and can deposit on reactor boundaries (e.g., heat exchangers), potentially representing design issues related to the degradation of heat exchange performance or radioactive hotspots. The integration of transport models for solid particles in multiphysics codes is therefore relevant for the prediction of deposited fractions. To this aim, we develop a multiphysics solver based on the OpenFOAM library to address the issue of solid fission products transport. Single-phase incompressible thermal hydraulics are coupled with neutron diffusion, and advection-diffusion-decay equations are implemented for fission products concentrations. Particle deposition and precipitation are considered as well. The developed solver is tested on two different MSFR application to showcase the capabilities of the solver in steady-state simulation and to investigate the role of precipitation and turbulence modeling in the determination of particle concentration distributions

A Robust Adaptive Hydraulic Power Generation System for Jet Engines

The paper presents an innovative hydraulic power generation system able to enhance performance, reliability and survivability of hydraulic systems used in military jet engines, as well as to allow a valuable power saving. This is obtained by a hydraulic power generation system architecture that uses variable pressure, smart control, emergency power source and suitable health management procedures. A key issue is to obtain all these functions while reducing to a minimum the number of additional components with respect to the conventional hydraulic power generation systems. The paper firstly presents the state-of-art of these systems and their critical issues, outlines the alternative solutions, and then describes architecture, characteristics and performance of the hydraulic power generation system that was eventually defined as a result of a research activity aimed at moving beyond the present state-of-art in this fiel