High Gain Amplifier with Enhanced Cascoded Compensation

A two-stage CMOS operational amplifier with both, gain-boosting and indirect current feedback frequency compensation performed by means of regulated cascode amplifiers, is presented. By using quasi-floating-gate transistors (QFGT) the supply requirements, the number of capacitors and the size of the compensation capacitors respect to other Miller schemes are reduced. A prototype was fabricated using a 0.5 μm technology, resulting, for a load of 45 pF and supply voltage of 1.65 V, in open-loop-gain of 129 dB, 23 MHz of gain-bandwidth product, 60o phase margin, 675 μW power consumption and 1% settling time of 28 ns

Ultra Low-Power Analog Median Filters

The design and implementation of three analog median filter topologies, whose transistors operate in the deep weak-inversion region, is described. The first topology is a differential pairs array, in which drain currents are driven into two nodes in a differential fashion, while the second topology is based on a wide range OTA, which is used to maximize the dynamic range. Finally, the third topology uses three range-extended OTAs. The proposed weak-inversion filters were designed and fabricated in ON Semiconductor 0.5 micrometer technology through MOSIS. Experimental results of three-input fabricated prototypes for all three topologies are show, where power consumptions of 90nW in the first case, and 270nW in the other two cases can be noticed. A dual power supply +/-1.5 Volts were used

Distance and age of the massive stellar cluster Westerlund 1. I. Parallax method using Gaia-EDR3

Westerlund 1 (Wd 1) is one of the most massive young star clusters in the Milky Way. Although relevant for star formation and evolution, its fundamental parameters are not yet very well constrained. Our goal is to derive an accurate distance and provide constraints on the cluster age. We used the photometric and astrometric information available in the Gaia Early Data Release 3 (Gaia-EDR3) to infer its distance of 4.06$^{+0.36}_{-0.34}$ kpc. Modelling of the eclipsing binary system W36 reported in Paper II led to the distance of 4.34$\pm$0.25 kpc, in agreement with the Gaia-EDR3 distance and, therefore, validating the parallax zero-point correction approach appropriate for red objects. By taking advantage of another two recent distance determinations using the Gaia-EDR3, we obtained a weighted mean distance for the cluster as d$_{\rm wd1}$=4.23$^{+0.15}_{-0.13}$ kpc ($m-M$=13.13$^{+0.08}_{-0.07}$ mag), which has an unprecedented accuracy of 4\%. We adopted recent Geneva evolutionary tracks for supra-solar metallicity objects to infer the age of the faintest RSG source from Wd 1, leading to a cluster age of 11.0$\pm$0.5 Myr, in excellent agreement with recent work by Beasor \& Davies (10.4$^{+1.3}_{-1.2}$ Myr) based on MIST evolutionary models. The age of W36 was reported to be 3.5$\pm$0.5 Myr in Paper II, supporting recent claims of a temporal spread of several Myr for the star-forming process within Wd 1 instead of a monolithic starburst scenario.Comment: 16 pages, 9 figures, revised version submitted to MNRAS on April 20th, 202

Novel approaches of nanoceria with magnetic, photoluminescent, and gas-sensing properties

The modification of CeO2 with rare-earth elements opens up a wide range of applications as biomedical devices using infrared emission as well as magnetic and gas-sensing devices, once the structural, morphological, photoluminescent, magnetic, electric, and gas-sensing properties of these systems are strongly correlated to quantum electronic transitions between rare-earth f-states among defective species. Quantitative phase analysis revealed that the nanopowders are free from secondary phases and crystallize in the fluorite-type cubic structure. Magnetic coercive field measurements on the powders indicate that the substitution of cerium with lanthanum (8 wt %), in a fluorite-type cubic structure, created oxygen vacancies and led to a decrease in the fraction of Ce species in the 3+ state, resulting in a stronger room-temperature ferromagnetic response along with high coercivity (160 Oe). In addition to the magnetic and photoluminescent behavior, a fast response time (5.5 s) was observed after CO exposure, indicating that the defective structure of ceria-based materials corresponds to the key of success in terms of applications using photoluminescent, magnetic, or electrical behaviors.Fil: Rocha, Leandro S.R.. Universidade Federal do São Carlos; BrasilFil: Amoresi, Rafael A.C.. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Moreno, Henrique. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Ramirez, Miguel A.. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Ponce, Miguel Adolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Foschini, Cesar R.. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Longo, Elson. Universidade Federal do São Carlos; BrasilFil: Simões, Alexandre Z.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasi

Effect of Nitrogen on Agronomic Yield, Spad Units and Nitrate Content in Roselle (Hibiscus Sabdariffal.) in Dry Weather

This study was conducted in polyethylene bags of 4 kg capacity with plants of Jamaica from seeds collected from an accession on the coast of Oaxaca, which were planted under the ecological conditions of Teotitlán de Flores Magón, and evaluated under completely randomized design, where treatments were four levels of nitrogen: 0, 50, 100 and 150 kg ha-1 and four repetitions (4x4) = 16 experimental units. The variables evaluated were: both agronomic yields: chalice and seed, harvest index, SPAD units and nitrate content in leaf. The results indicate that higher yields ofseed and chalice, biomass, nitrate content in leaf and SPAD units were achieved with the application of 100 kg ha-1 of nitrogen with 50.39, 196.80, 620.4 g plant-1, 85.00 mg kg-1 and 29.10 units, respectively. The content of nitrates and its relationship with SPAD units, adjusted to an increasing linear model for the four levels of nitrogen studied. From this study it can be concluded that the application of 100 kg N ha-1, positively affect the culture of Jamaica under dry weather conditions way

Basic physical parameters of a selected sample of evolved stars

We present the detailed spectroscopic analysis of 72 evolved stars, including the [Fe/H] determination for the whole sample. These metallicities, together with the Teff values and the absolute V magnitude derived from Hipparcos parallaxes, are used to estimate basic stellar parameters (ages, masses, radii, (B-V)o and log g using theoretical isochrones and a Bayesian estimation method. The (B-V)o values so estimated turn out to be in excellent agreement with the observed (B-V), confirming the reliability of the (Teff,(B-V)o) relation used in the isochrones. The estimated diameters have been compared with limb darkening-corrected ones measured with independent methods, finding an agreement better than 0.3 mas within the 1-10 mas interval. We derive the age-metallicity relation for the solar neighborhood; for the first time such a relation has been derived from observations of field giants rather than from open clusters and field dwarfs and subdwarfs. The age-metallicity relation is characterized by close-to-solar metallicities for stars younger than ~4 Gyr, and by a large [Fe/H] spread with a trend towards lower metallicities for higher ages. We find that the [Fe/H] dispersion of young stars (less than 1 Gyr) is comparable to the observational errors, indicating that stars in the solar neighbourhood are formed from interstellar matter of quite homogeneous chemical composition. The three giants of our sample which have been proposed to host planets are not metal rich, what is at odds with those for main sequence stars. However, two of these stars have masses much larger than a solar mass so we may be sampling a different stellar population from most radial velocity searches for extrasolar planets. We also confirm that the radial velocity variability tends to increase along the RGB.Comment: 17 pgs, 19 fig

Inhibition of aminoglycoside 6\u3csup\u3e′\u3c/sup\u3e-n-acetyltransferase type ib (Aac(6\u3csup\u3e′\u3c/sup\u3e )-ib): Structure–activity relationship of substituted pyrrolidine pentamine derivatives as inhibitors

The aminoglycoside 6′-N-acetyltransferase type Ib (AAC(6′ )-Ib) is a common cause of resistance to amikacin and other aminoglycosides in Gram-negatives. Utilization of mixture-based combinatorial libraries and application of the positional scanning strategy identified an inhibitor of AAC(6′ )-Ib. This inhibitor’s chemical structure consists of a pyrrolidine pentamine scaffold substituted at four locations (R1, R3, R4, and R5). The substituents are two S-phenyl groups (R1 and R4), an S-hydroxymethyl group (R3), and a 3-phenylbutyl group (R5). Another location, R2, does not have a substitution, but it is named because its stereochemistry was modified in some compounds utilized in this study. Structure–activity relationship (SAR) analysis using derivatives with different functionalities, modified stereochemistry, and truncations was carried out by assessing the effect of the addition of each compound at 8 µM to 16 µg/mL amikacin-containing media and performing checkerboard assays varying the concentrations of the inhibitor analogs and the antibiotic. The results show that: (1) the aromatic functionalities at R1 and R4 are essential, but the stereochemistry is essential only at R4; (2) the stereochemical conformation at R2 is critical; (3) the hydroxyl moiety at R3 as well as stereoconformation are required for full inhibitory activity; (4) the phenyl functionality at R5 is not essential and can be replaced by aliphatic groups; (5) the location of the phenyl group on the butyl carbon chain at R5 is not essential; (6) the length of the aliphatic chain at R5 is not critical; and (7) all truncations of the scaffold resulted in inactive compounds. Molecular docking revealed that all compounds preferentially bind to the kanamycin C binding cavity, and binding affinity correlates with the experimental data for most of the compounds evaluated. The SAR results in this study will serve as the basis for the design of new analogs in an effort to improve their ability to induce phenotypic conversion to susceptibility in amikacin-resistant pathogens

The Rewiring of Ubiquitination Targets in a Pathogenic Yeast Promotes Metabolic Flexibility, Host Colonization and Virulence

Funding: This work was funded by the European Research Council [http://erc.europa.eu/], AJPB (STRIFE Advanced Grant; C-2009-AdG-249793). The work was also supported by: the Wellcome Trust [www.wellcome.ac.uk], AJPB (080088, 097377); the UK Biotechnology and Biological Research Council [www.bbsrc.ac.uk], AJPB (BB/F00513X/1, BB/K017365/1); the CNPq-Brazil [http://cnpq.br], GMA (Science without Borders fellowship 202976/2014-9); and the National Centre for the Replacement, Refinement and Reduction of Animals in Research [www.nc3rs.org.uk], DMM (NC/K000306/1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Acknowledgments We thank Dr. Elizabeth Johnson (Mycology Reference Laboratory, Bristol) for providing strains, and the Aberdeen Proteomics facility for the biotyping of S. cerevisiae clinical isolates, and to Euroscarf for providing S. cerevisiae strains and plasmids. We are grateful to our Microscopy Facility in the Institute of Medical Sciences for their expert help with the electron microscopy, and to our friends in the Aberdeen Fungal Group for insightful discussions.Peer reviewedPublisher PD

Multiplicity dependence of jet-like two-particle correlations in p-Pb collisions at sNN\sqrt{s_{NN}} = 5.02 TeV

Two-particle angular correlations between unidentified charged trigger and associated particles are measured by the ALICE detector in p-Pb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV. The transverse-momentum range 0.7 $< p_{\rm{T}, assoc} < p_{\rm{T}, trig} <$ 5.0 GeV/$c$ is examined, to include correlations induced by jets originating from low momen\-tum-transfer scatterings (minijets). The correlations expressed as associated yield per trigger particle are obtained in the pseudorapidity range $|\eta|<0.9$. The near-side long-range pseudorapidity correlations observed in high-multiplicity p-Pb collisions are subtracted from both near-side short-range and away-side correlations in order to remove the non-jet-like components. The yields in the jet-like peaks are found to be invariant with event multiplicity with the exception of events with low multiplicity. This invariance is consistent with the particles being produced via the incoherent fragmentation of multiple parton--parton scatterings, while the yield related to the previously observed ridge structures is not jet-related. The number of uncorrelated sources of particle production is found to increase linearly with multiplicity, suggesting no saturation of the number of multi-parton interactions even in the highest multiplicity p-Pb collisions. Further, the number scales in the intermediate multiplicity region with the number of binary nucleon-nucleon collisions estimated with a Glauber Monte-Carlo simulation.Comment: 23 pages, 6 captioned figures, 1 table, authors from page 17, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/161