Los usuarios en la grieta: retomas de lo político en los sitios "Choripan & Vino" y "Peronismo Intergaláctico"

El trabajo que presentamos pretende ser un aporte descriptivo sobre los modos en los que se produce la lectura de lo político y su circulación en las redes sociales. Fue realizado en el marco del proyecto de investigación UBACyT “Absorciones y retomas discursivas. El campo de los efectos” (directora: María Rosa Del Coto; co-directora: Graciela Varela). Es importante destacar que la noción de medio es utilizada para denominar también a las redes sociales, partiendo de la definición que propone Eliseo Verón: “El término (…), designa para mí no solamente un dispositivo tecnológico particular (por ejemplo, la producción de imágenes y de sonidos sobre un soporte magnético) sino la conjunción de un soporte y de un sistema de prácticas de utilización (producción/reconocimiento)” (Verón: 2004: 144). Dentro del proyecto en el cual se enmarca esta investigación se entiende como retoma a los conceptos habilitados a partir de la década del ´70 alrededor de la definición intertextual de la vida discursiva (Bajtín, 1985; Kristeva, 1978; Angenot, 1996). "Todo enunciado es un eslabón en la cadena, muy complejamente organizada, de otros enunciados" Bajtín (1985).Eje 13. Análisis del discurso y estudios del lenguajeFacultad de Periodismo y Comunicación Socia

Los usuarios en la grieta: retomas de lo político en los sitios "Choripan & Vino" y "Peronismo Intergaláctico"

El trabajo que presentamos pretende ser un aporte descriptivo sobre los modos en los que se produce la lectura de lo político y su circulación en las redes sociales. Fue realizado en el marco del proyecto de investigación UBACyT “Absorciones y retomas discursivas. El campo de los efectos” (directora: María Rosa Del Coto; co-directora: Graciela Varela). Es importante destacar que la noción de medio es utilizada para denominar también a las redes sociales, partiendo de la definición que propone Eliseo Verón: “El término (…), designa para mí no solamente un dispositivo tecnológico particular (por ejemplo, la producción de imágenes y de sonidos sobre un soporte magnético) sino la conjunción de un soporte y de un sistema de prácticas de utilización (producción/reconocimiento)” (Verón: 2004: 144). Dentro del proyecto en el cual se enmarca esta investigación se entiende como retoma a los conceptos habilitados a partir de la década del ´70 alrededor de la definición intertextual de la vida discursiva (Bajtín, 1985; Kristeva, 1978; Angenot, 1996). "Todo enunciado es un eslabón en la cadena, muy complejamente organizada, de otros enunciados" Bajtín (1985).Eje 13. Análisis del discurso y estudios del lenguajeFacultad de Periodismo y Comunicación Socia

Los usuarios en la grieta: retomas de lo político en los sitios "Choripan & Vino" y "Peronismo Intergaláctico"

El trabajo que presentamos pretende ser un aporte descriptivo sobre los modos en los que se produce la lectura de lo político y su circulación en las redes sociales. Fue realizado en el marco del proyecto de investigación UBACyT “Absorciones y retomas discursivas. El campo de los efectos” (directora: María Rosa Del Coto; co-directora: Graciela Varela). Es importante destacar que la noción de medio es utilizada para denominar también a las redes sociales, partiendo de la definición que propone Eliseo Verón: “El término (…), designa para mí no solamente un dispositivo tecnológico particular (por ejemplo, la producción de imágenes y de sonidos sobre un soporte magnético) sino la conjunción de un soporte y de un sistema de prácticas de utilización (producción/reconocimiento)” (Verón: 2004: 144). Dentro del proyecto en el cual se enmarca esta investigación se entiende como retoma a los conceptos habilitados a partir de la década del ´70 alrededor de la definición intertextual de la vida discursiva (Bajtín, 1985; Kristeva, 1978; Angenot, 1996). "Todo enunciado es un eslabón en la cadena, muy complejamente organizada, de otros enunciados" Bajtín (1985).Eje 13. Análisis del discurso y estudios del lenguajeFacultad de Periodismo y Comunicación Socia

Macular Choroidal Thickness: Evaluation of Variability among Measurements and Assessment of Predictive Value of Glaucomatous Visual Field Damag

Introduction: This study aimed to investigate the relationship between the choroidal circulation and glaucoma, assessing macular choroidal thickness (MCT) as a predictive value of glaucomatous visual field damage. Methods: Twenty primary open-angle glaucoma patients were recruited. Patients underwent 2 SS-OCT scans: one with DRI OCT (Topcon) and the other with PLEX Elite 9000 (Zeiss). Standard OCT parameters were acquired by DRI OCT, while MCT was manually measured in 5 points on Plex ELITE 9000 images. The relationship among MCT, standard OCT parameters, and visual field indices was evaluated. Pearson''s r correlation was calculated to evaluate these relationships. Reproducibility of measurements was analyzed. Results: MCT measurements showed a good intra- and interobserver repeatability. A negative correlation appeared between MCT and BMI (r = -0.518, p = 0.023). Mean deviation showed a statistically significant correlation with MCT measured at subfoveal and at 1, 000 µm nasally (r = 0.50, p = 0.03, and r = 0.52, p = 0.023). A correlation was found between the 2 MCT (Zeiss vs. Topcon) measurements and between MCT and peripapillary choroidal thickness (r = 0.944 and r = 0.740, p < 0.001, respectively). Conclusions: A good intra- and interobserver reproducibility was found. MCT showed a weak predictive value of glaucomatous visual field damage. A significant correlation was found between MCT and BMI. © 202

Ocular involvement in hereditary transthyretin amyloidosis: A case series describing novel potential biomarkers

Hereditary transthyretin amyloidosis (hATTR) is a rare disease caused by a point mutation in the transthyretin (TTR) gene and inherited in an autosomal dominant fashion. TTR is a plasma protein that functions as a carrier for thyroxine (T4) and retinol (vitamin A). Ophthalmological manifestations are due to both the hepatic and ocular production of mutated TTR. In this case series, we report the ocular manifestations of hATTR in eighteen eyes of nine consecutive patients. Corneal nerve abnormalities as well as morphological and functional changes in the retina were investigated. The study was a single-center, retrospective, observational, clinical case series. In all patients, corneal confocal microscopy (CCM), multimodal imaging of the retina, including fundus photography and Optical Coherence Tomography (OCT), as well as rod and cone electroretinography (ERG) were performed. Eight patients had active disease and one was an unaffected carrier. In all study eyes, corneal nerve plexa examined with CCM were poorly represented or absent. Mixed rod-cone and cone ERG b-wave amplitudes were reduced, and photopic b-wave responses were significantly delayed. Photopic Negative Response (PhNR) amplitude was significantly reduced, while PhNR latency was significantly augmented. In 13/18 eyes, vitreous opacities and abnormalities of vitreo-retinal interface were found. The current results highlight the presence of corneal nerve damage. Functional retinal abnormalities, detected by ERG, can be found even in the presence of minimal or absent structural retinal damage. These findings support the use of CCM and ERGs to detect early biomarkers for primary hATTR

Ocular Involvement in Hereditary Amyloidosis

The term amyloidosis describes a group of rare diseases caused by protein conformation abnormalities resulting in extracellular deposition and accumulation of insoluble fibrillar aggregates. So far, 36 amyloid precursor proteins have been identified, and each one is responsible for a specific disease entity. Transthyretin amyloidosis (ATTRv) is one of the most common forms of systemic and ocular amyloidosis, due to the deposition of transthyretin (TTR), which is a transport protein mainly synthesized in the liver but also in the retinal pigment epithelial cells. ATTRv amyloidosis may be misdiagnosed with several other conditions, resulting in a significant diagnostic delay. Gelsolin and keratoepithelin are other proteins that, when mutated, are responsible for a systemic amyloid disease with significant ocular manifestations that not infrequently appear before systemic involvement. The main signs of ocular amyloid deposition are in the cornea, irido-corneal angle and vitreous, causing complications related to vasculopathy and neuropathy at the local level. This review aims at describing the main biochemical, histopathological and clinical features of systemic amyloidosis associated with eye involvement, with particular emphasis on the inherited forms. We discuss currently available treatments, focusing on ocular involvement and specific ophthalmologic management and highlighting the importance of a prompt treatment for the potential sight-threatening complications derived from amyloid deposition in ocular tissues

Route knowledge and configural knowledge in typical and atypical development: a comparison of sparse and rich environments

Background: Individuals with Down syndrome (DS) and individuals with Williams syndrome (WS) have poor navigation skills, which impact their potential to become independent. Two aspects of navigation were investigated in these groups, using virtual environments (VE): route knowledge (the ability to learn the way from A to B by following a fixed sequence of turns) and configural knowledge (knowledge of the spatial relationships between places within an environment). Methods: Typically developing (TD) children aged 5 to 11 years (N = 93), individuals with DS (N = 29) and individuals with WS (N = 20) were presented with a sparse and a rich VE grid maze. Within each maze, participants were asked to learn a route from A to B and a route from A to C before being asked to find a novel shortcut from B to C. Results: Performance was broadly similar across sparse and rich mazes. The majority of participants were able to learn novel routes, with poorest performance in the DS group, but the ability to find a shortcut, our measure of configural knowledge, was limited for all three groups. That is, 59 % TD participants successfully found a shortcut, compared to 10 % participants with DS and 35 % participants with WS. Differences in the underlying mechanisms associated with route knowledge and configural knowledge and in the developmental trajectories of performance across groups were observed. Only the TD participants walked a shorter distance in the last shortcut trial compared to the first, indicative of increased configural knowledge across trials. The DS group often used an alternative strategy to get from B to C, summing the two taught routes together. Conclusions: Our findings demonstrate impaired configural knowledge in DS and in WS, with the strongest deficit in DS. This suggests that these groups rely on a rigid route knowledge based method for navigating and as a result are likely to get lost easily. Route knowledge was also impaired in both DS and WS groups and was related to different underlying processes across all three groups. These are discussed with reference to limitations in attention and/or visuo-spatial processing in the atypical groups

A homozygous MED11 C-terminal variant causes a lethal neurodegenerative disease

Purpose: The mediator (MED) multisubunit-complex modulates the activity of the transcriptional machinery, and genetic defects in different MED subunits (17, 20, 27) have been implicated in neurologic diseases. In this study, we identified a recurrent homozygous variant in MED11 (c.325C>T; p.Arg109Ter) in 7 affected individuals from 5 unrelated families. Methods: To investigate the genetic cause of the disease, exome or genome sequencing were performed in 5 unrelated families identified via different research networks and Matchmaker Exchange. Deep clinical and brain imaging evaluations were performed by clinical pediatric neurologists and neuroradiologists. The functional effect of the candidate variant on both MED11 RNA and protein was assessed using reverse transcriptase polymerase chain reaction and western blotting using fibroblast cell lines derived from 1 affected individual and controls and through computational approaches. Knockouts in zebrafish were generated using clustered regularly interspaced short palindromic repeats/Cas9. Results: The disease was characterized by microcephaly, profound neurodevelopmental impairment, exaggerated startle response, myoclonic seizures, progressive widespread neurodegeneration, and premature death. Functional studies on patient-derived fibroblasts did not show a loss of protein function but rather disruption of the C-terminal of MED11, likely impairing binding to other MED subunits. A zebrafish knockout model recapitulates key clinical phenotypes. Conclusion: Loss of the C-terminal of MED subunit 11 may affect its binding efficiency to other MED subunits, thus implicating the MED-complex stability in brain development and neurodegeneration

Convertiseur cc-cc a sorties multiplies

DC D converter with multiple output

DC-DC CONVERTER WITH MULTIPLE OUTPUTS

A multiple output DC-DC converter comprises a transformer, a primary circuit, a plurality of secondary circuits, and a controller. The transformer has a primary and at least one secondary winding. The primary circuit connects to a DC power supply source and includes the primary winding of the transformer and a primary switch connected in series. The plurality of secondary circuits includes the at least one secondary winding of the transformer, wherein each secondary circuit provides a DC power supply output, and at least one of the secondary circuits has a secondary switch. The controller monitors an output signal of each secondary circuit and controls operation of the primary and secondary switches based on the monitored signals. The controller co-ordinates operation of the secondary switch with the primary switch, such that the primary switch and the secondary switch are switched on simultaneously, or with a controlled offset