Post colonoscopic acute bacterial prostatitis: a case report

Colonoscopy is a common procedure for diagnosing a wide range of conditions and symptoms affecting the large bowel. Research has shown that the examination itself may induce transient bacterial infections. Specifically acute bacterial prostatitis (ABP) has little mention in medical literature as a recognized complication of this procedure. Here we discuss a 37 year old male presenting with symptoms suggesting lower urinary tract infection after having undergone colonoscopy followed by recurrent episodic haematuria and lower urinary tract symptoms (LUTS). Physicians and endoscopists should be aware of the risk of acute bacterial prostatitis as a potential complication of colonoscopy in order to minimize misdiagnosis as well as the complications associated with the delayed treatment of it. In addition male patients and the immunocompromised should be fully counselled regarding this risk prior to undertaking this procedure

Parkinson disease prediction using improved crayfish optimization based hybrid deep learning

Background Predicting the course of Parkinson's disease is essential for prompt diagnosis and treatment, which may enhance patient outcomes. Objective This study presents a novel method for Parkinson's disease prediction using freely accessible resources. The suggested approach starts with band-pass filter data preprocessing and uses Empirical Mode Decomposition (EMD) for feature extraction. Then, for classification, these features are supplied into an Attention-based Efficient Bidirectional Network (ImCfO_Attn_EffBNet) based on Improved Crayfish Optimization. EfficientNet-B7, BiLSTM, and Attention modules are integrated by ImCfO_Attn_EffBNet to effectively gather temporal and geographic data. Methods Additionally, we use the Improved Crayfish Optimization (ImCfO) algorithm to maximize convergence rates, optimize the loss function, and find the global best solutions. Results ImCfO enhances performance by adding a self-adaptation criterion to the traditional crayfish algorithm. The classifier's configurable parameters are adjusted using the ImCfO resultant solution, which raises the prediction accuracy overall. Conclusion Based on a number of assessments, the ImCfO_Attn_EffBNet analyzed the performance and found that the results were as follows: accuracy (95.068%), recall (92.948%), specificity (92.89%), F-Score (92.89%), precision (92.89%), and FPR (2.1%), in that order

A rare case of recurrent cerebrospinal fluid rhinorrhea

Cerebrospinal fluid (CSF) rhinorrhea is the leakage of cerebrospinal fluid through the nostrils due to an abnormal communication between the nasal cavity and sub–arachnoid space. CSF rhinorrhoea can be traumatic or spontaneous. CSF rhinorrhea carries a risk of ascending infection leading to meningitis. CSF rhinorrhea is not very common and could be easily mistaken for rhinitis. Physicians need to have a high index of suspicion to diagnose and treat this rare and potentially serious condition. Here we discuss a case of delayed post-traumatic CSF rhinorrhea -an unusual presentation in a primary care setting, focusing on presentation and diagnosis

The impact of maternal obesity on maternal and fetal outcome

Background: Obesity continues to be a global health concern. Although the increasing obesity rates in developed countries has slowed down in the past 10 years, obesity rates in developing countries continue to increase, as much as three times in some developing countries over the past 30 years. The aim of the study was to determine the adverse effects of obesity in pregnancy and maternal and fetal outcome.Methods: In all patients, a detailed history was taken and examinations and investigations were carried out.  Based on BMI (body mass index), patients were divided into 2 groups. Group 1 = patients with BMI >30 kg/m2 and Group 2 = patients with BMI 30 kg/m2 and normal BMI, authors found that the prevalence of maternal and fetal complications was higher in the obese group. Prevalence of antenatal complications like gestational hypertension, preeclampsia, imminent eclampsia and gestational diabetes mellitus requiring control with insulin was higher in obese women.Conclusions: Obesity is associated with increased adverse effects on pregnancy and its outcome

Influence of land preparation on weed dynamics and growth of traditional rice landraces in the diverged location of Tamil Nadu

In recent years, traditional landraces are gaining importance due to its many health benefits. But the main drawback of the traditional rice variety is low productivity with increased water consumption. Therefore different rice establishment methods are to be evaluated. But weed infestation occurs in every establishment method. Hence the present study aimed to study the weed dynamics by evaluating the water-saving technologies compared with puddled transplanting using various landraces. The first field experiment was conducted during Samba (Aug-Sept) 2021 in the wetlands of Tamil Nadu Agricultural University, Coimbatore. The second field experiment was at the Research Station, Melalathur in Tamil Nadu during Navara (Nov-Jan) season 2021. The experiment was laid out in split plot design comprising four establishment methods as main plots viz. Aerobic rice (M1), Puddled transplanting (M2), Unpuddled transplanting (M3), Direct seeded rice (M4) with traditional landraces viz. Karuppu kavuni (V1), Mapillai samba (V2) and Seeraga samba (V3) in sub plots. In this study, weed dynamics like weed density and weed dry weight were recorded along with plant height, leaf area index and total chlorophyll content. Weed density and weed dry weight was 87.82 % and 74.63 % higher in aerobic rice cultivation than puddled transplanting method during all the observations in both experiments. On comparing the land establishment methods, Direct seeded rice performed well with 40.61% of higher plant height, 89.38 % of higher LAI, 38.48 % of increased total chlorophyll content than Aerobic rice cultivation. The landrace mapillai samba showed a significantly (p<0.05) higher plant height of 64.09±7.14 cm, Leaf area index of 2.05±0.992 and total chlorophyll content of 2.56±0.461 mg/g of fresh leaf. Hence this study provides evidence that in the initial stage of rice cultivation, direct seeded rice and the mapillai samba landrace performed well than the other establishment methods and the other two landraces. 

Application of santalin dye extracted from Pterocarpus santalinus (red sandalwood) as a natural colorimetric indicator for real-time monitoring of spoilage in ready-to-cook idly batter

The growing demand for natural and eco-friendly solutions in food quality monitoring has sparked significant interest in using natural dyes as sustainable alternatives to chemical dyes for detecting food freshness. In this study, a colorimetric indicator based on natural santalin dye was developed for real-time monitoring of spoilage in ready-to-cook (RTC) idly batter. Santalin, extracted from Pterocarpus santalinus (red sandalwood), is a stable red pigment renowned for its antioxidant, antimicrobial, and antiinflammatory properties. The santalin dye was immobilised in a polyvinyl alcohol-methylcellulose matrix and applied to cellulose paper, creating a low-cost pH-sensitive colorimetric indicator label. The developed indicator label displayed a visible colour change from dark brown to lighter brown hues in response to increased carbon dioxide concentrations, corresponding with a decrease in pH from 5.3 to 4.0 and a rise in titratable acidity (TA) from 0.5% to 0.9 % during the spoilage of RTC idly batter. The colour changes were captured and converted into grayscale images for pixel intensity analysis using MATLAB. The results revealed a consistent decline in mean pixel intensity as fermentation and spoilage progressed, demonstrating the effectiveness of the santalin-based indicator. This novel, natural santalin dye-based indicator offers a promising alternative to synthetic indicators, addressing safety concerns such as chemical migration into food. It can thus serve as an "on-package sticker" for real-time monitoring of spoilage in RTC idly batter

Investigating the therapeutic potential of Celosia cristata via GC-MS characterization and in silico docking

Celosia cristata, an annual shrub belonging to the family Amaranthaceae, is widely cultivated in India for its vibrant flowers. This study investigates the GC-MS profiling and antibacterial activity of Celosia cristata flower extract. Antibacterial efficacy of the extracts was tested against Escherichia coli and Staphylococcus aureus using the agar well diffusion method at concentrations ranging from 10–50 µL. The extract exhibited moderate antibacterial activity, with inhibition zones of 10 –15 mm against E. coli. GC-MS analysis identified 25 major phytochemical constituents, namely Hentriacontane (19.52 %), Benzoic acid, 4-ethoxy-, ethyl ester (11.87 %), Heptacosanol (10.97 %), Cyclotetracosane (6.01 %) and Butane, 2-phenyl-3-(trimethylsilyloxy) (1.57 %). Many of these compounds are known for their antioxidant, antimicrobial and anti-inflammatory properties. Further, molecular docking studies revealed that diphenyl sulfone may have potential inhibitory activity against E. coli haemolysin E (1QOY). Collectively, these findings highlight the therapeutic potential of Celosia cristata in pharmaceutical applications and antimicrobial drug development

FASTRA – SAFE AND SECURE

The innovative congestion control algorithm named FASTRA (Fast Active Stability TCP) is aimed for high-speed long-latency networks. Four major difficulties in FASTRA are highlighted at both packet and flow levels. The architecture and characterization of equilibrium and stability properties of FASTRA are robust. Experimental results of FASTRA outsmart TCP Reno, HSTCP, and STCP in terms of throughput, fairness, stability, and responsiveness. FASTRA aims to rapidly stabilize high-speed long-latency networks into steady, efficient and fair operating points, in dynamic sharing environments, and the preliminary results are produced as output of our project. The Proposed architecture is explained with the help of an existing real-time example as to explain why FASTRA download is chosen rather than FTP download. The Paper is concluded with the results of the new congestion control algorithm aided with the graphs obtained during its simulation in NS2. On proper implementation, many safe, FASTRA downloads and data transfers can be carried over a high speed internet network

Suppressive effects of Schizandra chinensis Baillon water extract on allergy-related cytokine generation and degranulation in IgE-antigen complex-stimulated RBL-2H3 cells

Schizandra chinensis Baillon is a traditional folk medicine plant that is used to treat and prevent several inflammatory diseases and cancer in Korea, but the underlying mechanisms involved in its anti-allergic activity are not fully understood. This study was designed to investigate mechanisms of anti-allergic activity of a Schizandra chinensis Baillon water extract (SCWE) in immunoglobulin E (IgE)-antigen complex-stimulated RBL2H3 cells and to assess whether gastric and intestinal digestion affects the anti-allergic properties of SCWE. Oxidative stress is an important consequence of the allergic inflammatory response. The antioxidant activities of SCWE increased in a concentration-dependent manner. RBL-2H3 cells were sensitized with monoclonal anti-dinitrophenol (DNP) specific IgE, treated with SCWE, and challenged with the antigen DNP-human serum albumin. SCWE inhibited β-hexosaminidase release and expression of interleukin (IL)-4, IL-13, and tumor necrosis factor-alpha (TNF-α) mRNA and protein in IgE-antigen complex-stimulated RBL2H3 cells. We found that digested SCWE fully maintained its antioxidant activity and anti-allergic activity against the IgE-antigen complex-induced activation of RBL-2H3 cells. SCWE may be useful for preventing allergic diseases, such as asthma. Thus, SCWE could be used as a natural functional ingredient for allergic diseases in the food and/or pharmaceutical industries

Dialysis-associated peritonitis in children

Peritonitis remains a frequent complication of peritoneal dialysis in children and is the most common reason for technique failure. The microbiology is characterized by a predominance of Gram-positive organisms, with fungi responsible for less than 5% of episodes. Data collected by the International Pediatric Peritonitis Registry have revealed a worldwide variation in the bacterial etiology of peritonitis, as well as in the rate of culture-negative peritonitis. Risk factors for infection include young age, the absence of prophylactic antibiotics at catheter placement, spiking of dialysis bags, and the presence of a catheter exit-site or tunnel infection. Clinical symptoms at presentation are somewhat organism specific and can be objectively assessed with a Disease Severity Score. Whereas recommendations for empiric antibiotic therapy in children have been published by the International Society of Peritoneal Dialysis, epidemiologic data and antibiotic susceptibility data suggest that it may be desirable to take the patient- and center-specific history of microorganisms and their sensitivity patterns into account when prescribing initial therapy. The vast majority of patients are treated successfully and continue peritoneal dialysis, with the poorest outcome noted in patients with peritonitis secondary to Gram-negative organisms or fungi and in those with a relapsing infection