The Brera Multi-scale Wavelet (BMW) ROSAT HRI source catalog. I: the algorithm

We present a new detection algorithm based on the wavelet transform for the analysis of high energy astronomical images. The wavelet transform, due to its multi-scale structure, is suited for the optimal detection of point-like as well as extended sources, regardless of any loss of resolution with the off-axis angle. Sources are detected as significant enhancements in the wavelet space, after the subtraction of the non-flat components of the background. Detection thresholds are computed through Monte Carlo simulations in order to establish the expected number of spurious sources per field. The source characterization is performed through a multi-source fitting in the wavelet space. The procedure is designed to correctly deal with very crowded fields, allowing for the simultaneous characterization of nearby sources. To obtain a fast and reliable estimate of the source parameters and related errors, we apply a novel decimation technique which, taking into account the correlation properties of the wavelet transform, extracts a subset of almost independent coefficients. We test the performance of this algorithm on synthetic fields, analyzing with particular care the characterization of sources in poor background situations, where the assumption of Gaussian statistics does not hold. For these cases, where standard wavelet algorithms generally provide underestimated errors, we infer errors through a procedure which relies on robust basic statistics. Our algorithm is well suited for the analysis of images taken with the new generation of X-ray instruments equipped with CCD technology which will produce images with very low background and/or high source density.Comment: 8 pages, 6 figures, ApJ in pres

Metallicity Gradients in the Intracluster Gas of Abell 496

Analysis of spatially resolved ASCA spectra of the intracluster gas in Abell 496 confirms there are mild metal abundance enhancements near the center, as previously found by White et al. (1994) in a joint analysis of Ginga LAC and Einstein SSS spectra. Simultaneous analysis of spectra from all ASCA instruments (SIS + GIS) shows that the iron abundance is 0.36 +- 0.03 solar 3-12' from the center of the cluster and rises ~50% to 0.53 +- 0.04 solar within the central 2'. The F-test shows that this abundance gradient is significant at the >99.99% level. Nickel and sulfur abundances are also centrally enhanced. We use a variety of elemental abundance ratios to assess the relative contribution of SN Ia and SN II to the metal enrichment of the intracluster gas. We find spatial gradients in several abundance ratios, indicating that the fraction of iron from SN Ia increases toward the cluster center, with SN Ia accounting for ~50% of the iron mass 3-12' from the center and ~70% within 2'. The increased proportion of SN Ia ejecta at the center is such that the central iron abundance enhancement can be attributed wholly to SN Ia; we find no significant gradient in SN II ejecta. These spatial gradients in the proportion of SN Ia/II ejecta imply that the dominant metal enrichment mechanism near the center is different than in the outer parts of the cluster. We show that the central abundance enhancement is unlikely to be due to ram pressure stripping of gas from cluster galaxies, or to secularly accumulated stellar mass loss within the central cD. We suggest that the additional SN Ia ejecta near the center is the vestige of a secondary SN Ia-driven wind from the cD (following a more energetic protogalactic SN II-driven wind phase), which was partially smothered in the cD due to its location at the cluster center.Comment: 25 pages AASTeX; 6 encapsulated PostScript figures; accepted for publication in ApJ. Replaced with revised versio

Gemini and Chandra observations of Abell 586, a relaxed strong-lensing cluster

We analyze the mass content of the massive strong-lensing cluster Abell 586 ($z = 0.17$). We use optical data (imaging and spectroscopy) obtained with the Gemini Multi-Object Spectrograph (GMOS) mounted on the 8-m Gemini-North telescope, together with publicly available X-ray data taken with the \textit{Chandra} space telescope. Employing different techniques -- velocity distribution of galaxies, weak gravitational lensing, and X-ray spatially resolved spectroscopy -- we derive mass and velocity dispersion estimates from each of them. All estimates agree well with each other, within a 68% confidence level, indicating a velocity dispersion of 1000 -- 1250 \kms. The projected mass distributions obtained through weak-lensing and X-ray emission are strikingly similar, having nearly circular geometry. We suggest that Abell 586 is probably a truly relaxed cluster, whose last major merger occurred more than $\sim 4$ Gyr agoComment: ApJ accepted, 20 pages, 11 figures; Figure 1 fixe

Radial Temperature Profiles of X-Ray--Emitting Gas Within Clusters of Galaxies

Previous analyses of ASCA data of clusters of galaxies have found conflicting results regarding the slope of the temperature profile of the hot X-ray gas within clusters, mainly because of the large, energy-dependent point spread function (PSF) of the ASCA mirrors. We present a summary of all ASCA-determined cluster temperature profiles found in the literature, and find a discrepancy in the radial temperature trend of clusters based on which PSF-correction routine is used. This uncertainty in the cluster temperature profile in turn can lead to large uncertainties in the amount of dark matter in clusters. In this study, we have used ROSAT PSPC data to obtain independent relative temperature profiles for 26 clusters, most of which have had their temperature profiles determined by ASCA. Our aim is not to measure the actual temperature values of the clusters, but to use X-ray color profiles to search for a hardening or softening of the spectra with radius for comparison to ASCA-derived profiles. The radial color profiles indicate that outside of the cooling flow region, the temperature profiles of clusters are in general constant. Within 35% of the virial radius, we find a temperature drop of 20% at 10 keV and 12% at 5 keV can be ruled out at the 99% confidence level. A subsample of non-cooling flow clusters shows that the condition of isothermality applies at very small radii too, although cooling gas complicates this determination in the cooling flow subsample. The colors predicted from the temperature profiles of a series of hydrodynamical cluster simulations match the data very well, although they cannot be used to discriminate among different cosmologies. An additional result is that the color profiles show evidence for a central peak in metallicity in low temperature clusters.Comment: 39 pages, 15 embedded Postscript figures, uses aaspp4.sty, accepted for publication in Astrophysical Journa

The BMW Detection Algorithm applied to the Chandra Deep Field south: deeper and deeper

Chandra deep fields represent the deepest look at the X-ray sky. We analyzed the Chandra Deep Field South (CDFS) with the aid of a dedicated wavelet-based algorithm. Here we present a detailed description of the procedures used to analyze this field, tested and verified by means of extensive simulations. We show that we can safely reconstruct the LogN-Log S source distribution of the CDFS down to limiting fluxes of 2.4x10^-17 and 2.1x10^-16 erg s^-1 cm^-2 in the soft (0.5-2 keV) and hard (2-10 keV) bands, respectively, fainter by a factor ~ 2 than current estimates. At these levels we can account for ~ 90% of the 1-2 keV and 2-10 keV X-ray background.Comment: 27 pages 16 figures, accepted for publication in the Astrophysical Journa

The Brera Multi-scale Wavelet Chandra Survey. I. Serendipitous source catalogue

We present the BMW-Chandra source catalogue drawn from essentially all Chandra ACIS-I pointed observations with an exposure time in excess of 10ks public as of March 2003 (136 observations). Using the wavelet detection algorithm developed by Lazzati et al. (1999) and Campana et al. (1999), which can characterise both point-like and extended sources, we identified 21325 sources. Among them, 16758 are serendipitous, i.e. not associated with the targets of the pointings, and do not require a non-automated analysis. This makes our catalogue the largest compilation of Chandra sources to date. The 0.5--10 keV absorption corrected fluxes of these sources range from ~3E-16 to 9E-12 erg cm^-2 s^-1 with a median of 7E-15 erg cm^-2 s^-1. The catalogue consists of count rates and relative errors in three energy bands (total, 0.5-7keV; soft, 0.5-2keV; and hard, 2-7keV), and source positions relative to the highest signal-to-noise detection among the three bands. The wavelet algorithm also provides an estimate of the extension of the source. We include information drawn from the headers of the original files, as well, and extracted source counts in four additional energy bands, SB1 (0.5-1keV), SB2 (1-2keV), HB1 (2-4keV), and HB2 (4-7keV). We computed the sky coverage for the full catalogue and for a subset at high Galactic latitude (|b|> 20deg). The complete catalogue provides a sky coverage in the soft band (0.5-2keV, S/N =3) of ~8 deg^2 at a limiting flux of 1E-13 erg cm^-2 s^-1, and ~2 deg^2 at a limiting flux of ~1E-15 erg cm^-2 s^-1.Comment: Accepted by A&A, Higher res. Figs 4 and 5 at http://www.ifc.inaf.it/~romano/BMC/Docs/aapaper/9601f4.eps http://www.ifc.inaf.it/~romano/BMC/Docs/aapaper/9601f5.eps, Catalog Web pages: http://www.brera.inaf.it/BMC/bmc_home.html http://www.ifc.inaf.it/~romano/BMC/bmc_home.html (Mirror

Properties of the intracluster medium in an ensemble of nearby galaxy clusters

We present a systematic analysis of the intracluster medium (ICM) in an X-ray flux limited sample of 45 galaxy clusters. Using archival ROSAT Position-Sensitive Proportional Counter (PSPC) data and published ICM temperatures, we present best-fit double and single beta model profiles, and extract ICM central densities and radial distributions. We use the data and an ensemble of numerical cluster simulations to quantify sources of uncertainty for all reported parameters. We examine the ensemble properties within the context of models of structure formation and feedback from galactic winds. We present best-fit ICM mass-temperature M-ICM-[T-X] relations for M-ICM calculated within r(500) and 1 h(50)(-1) Mpc. These relations exhibit small scatter (17%), providing evidence of regularity in large, X-ray flux limited cluster ensembles. Interestingly, the slope of the M-ICM-[T-X] relation (at limiting radius r(500)) is steeper than the self-similar expectation by 4.3 sigma. We show that there is a mild dependence of ICM mass fraction f(ICM) on [T-X]; the clusters with ICM temperatures below 5 keV have a mean ICM mass fraction [f(ICM)] = 0.160 +/- 0.008, which is significantly lower than that of the hotter clusters [f(ICM)] = 0.212 +/- 0.006 (90% confidence intervals). In apparent contradiction with previously published analyses, our large, X-ray flux limited cluster sample provides no evidence for a more extended radial ICM distribution in low-[T-X] clusters down to the sample limit of 2.4 keV. By analyzing simulated clusters we find that density variations enhance the cluster X-ray emission and cause M-ICM and f(ICM) to be overestimated by similar to 12%. Additionally, we use the simulations to estimate an f(ICM) depletion factor at r(500). We use the bias corrected mean f(ICM) within the hotter cluster subsample as a lower limit on the cluster baryon fraction. In combination with nucleosynthesis constraints this measure provides a firm upper limit on the cosmological density parameter for clustered matter Omega(M) less than or equal to (0.36 +/- 0.01) h(50)(-1/2).Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/60582/1/Mohr1999Properties.pd

Four Extreme Relic Radio Sources in Clusters of Galaxies

(Abridged) We describe the results of the highest-resolution radio observations yet made of four relic radio sources in the Abell clusters A13, A85, A133 and A4038. Our VLA images at 1.4 GHz with 4" resolution show a remarkable variety of fine structure in the form of spectacular arcs, wisps, plumes and loops. Their integrated radio flux densities fall very rapidly with frequency, with power-law slopes between 2.1 and 4.4 near 1.4 GHz The relics possess linear polarization levels ranging between 2.3 % (A133) and 35 % (A85); the higher polarization fractions imply a highly ordered magnetic field in the fine structure and low differential Faraday rotation in the intervening cluster gas. The optical identification of host galaxies remains problematic. In A85, A133 and A4038 the travel times for the brightest cluster galaxies are significantly longer than the modeled ages of the relics and nearby bright ellipticals provide a better match. Excess X-ray emission in the 0.5 keV-to-2 keV band was found near the relics in A85 and A133. The surface brightness was too high to be attributed to the inverse-Compton mechanism alone. We found excellent fits to the broad-band radio spectra using the anisotropic (KGKP) model of spectral ageing, and we have extended the model to include diffusion of particles between regions of different field strength (the Murgia-JP, or MJP, model). The steep radio spectra imply ages for the relics of ~ 10^8 yr, at the start of which period their radio luminosities would have been ~ 10^25 W/Hz at 1.4 GHz.Comment: 43 pages, 13 figures, AJ, Sep 2001 (accepted

The Lysosome and Intracellular Signalling.

In addition to being the terminal degradative compartment of the cell's endocytic and autophagic pathways, the lysosome is a multifunctional signalling hub integrating the cell's response to nutrient status and growth factor/hormone signalling. The cytosolic surface of the limiting membrane of the lysosome is the site of activation of the multiprotein complex mammalian target of rapamycin complex 1 (mTORC1), which phosphorylates numerous cell growth-related substrates, including transcription factor EB (TFEB). Under conditions in which mTORC1 is inhibited including starvation, TFEB becomes dephosphorylated and translocates to the nucleus where it functions as a master regulator of lysosome biogenesis. The signalling role of lysosomes is not limited to this pathway. They act as an intracellular Ca2+ store, which can release Ca2+ into the cytosol for both local effects on membrane fusion and pleiotropic effects within the cell. The relationship and crosstalk between the lysosomal and endoplasmic reticulum (ER) Ca2+ stores play a role in shaping intracellular Ca2+ signalling. Lysosomes also perform other signalling functions, which are discussed. Current views of the lysosomal compartment recognize its dynamic nature. It includes endolysosomes, autolysosome and storage lysosomes that are constantly engaged in fusion/fission events and lysosome regeneration. How signalling is affected by individual lysosomal organelles being at different stages of these processes and/or at different sites within the cell is poorly understood, but is discussed

Stereoselective Activity of 1-Propargyl-4-styrylpiperidine-like Analogues That Can Discriminate between Monoamine Oxidase Isoforms A and B

The resurgence of interest in monoamine oxidases (MAOs) has been fueled by recent correlations of this enzymatic activity with cardiovascular, neurological, and oncological disorders. This has promoted increased research into selective MAO-A and MAO-B inhibitors. Here, we shed light on how selective inhibition of MAO-A and MAO-B can be achieved by geometric isomers of cis-and trans-1-propargyl-4-styrylpiperidines. While the cis isomers are potent human MAO-A inhibitors, the trans analogues selectively target only the MAO-B isoform. The inhibition was studied by kinetic analysis, UV-vis spectrum measurements, and X-ray crystallography. The selective inhibition of the MAO-A and MAO-B isoforms was confirmed ex vivo in mouse brain homogenates, and additional in vivo studies in mice show the therapeutic potential of 1-propargyl-4-styrylpiperidines for central nervous system disorders. This study represents a unique case of stereoselective activity of cis/trans isomers that can discriminate between structurally related enzyme isoforms