The nearby Galaxy structure toward the Vela Gum nebula

We report on $UBVI$ photometry and spectroscopy for MK classification purposes carried out in the fields of five open clusters projected against the Vela Gum in the Third Galactic Quadrant of the Galaxy. They are Ruprecht 20, Ruprecht 47, Ruprecht 60, NGC 2660 and NGC 2910. We could improve/confirm the parameters of these objects derived before. The spectroscopic parallax method has been applied to several stars located in the fields of four out of the five clusters to get their distances and reddenings. With this method we found two blue stars in the field of NGC 2910 at distances that make them likely members of Vela OB1 too. Also, projected against the fields of Ruprecht 20 and Ruprecht 47 we have detected other young stars favoring not only the existence of Puppis OB1 and OB2 but conforming a young stellar group at $\sim1$ kpc from the Sun and extending for more than 6 kpc outward the Galaxy. If this is the case, there is a thickening of the thin Galactic disk of more than 300 pc at just 2-3 kpc from the Sun. Ruprecht 60 and NGC 2660 are too old objects that have no physical relation with the associations under discussion. An astonishing result has been the detection in the background of Ruprecht 47 of a young star at the impressive distance of 9.5 kpc from the Sun that could be a member of the innermost part of the Outer Arm. Another far young star in the field of NGC 2660, at near 6.0 kpc, may become a probable member of the Perseus Arm or of the inner part of the Local Arm. The distribution of young clusters and stars onto the Third Galactic Quadrant agrees with recent findings concerning the extension of the Local Arm as revealed by parallaxes of regions of star formation. We show evidences too that added to previous ones found by our group explain the thickening of the thin disk as a combination of flare and warp.Comment: Accepted for publication in New Astronom

Problemas cuantitativos y comprensión de conceptos

Los docentes de química a nivel universitario usamos «problemas», habitualmente de tipo cuantitativo, para enseñar y para evaluar. En este trabajo ponemos en duda de que lo hagamos en forma eficaz. Se muestra, a partir de pruebas diagnósticas de pares de problemas (uno cuantitativo y otro cualitativo similar), que muchos estudiantes pueden resolver los problemas cuantitativos sin una adecuada comprensión conceptual.Chemistry professors at university level make use of «problems», usually of a quantitative type, to teach and evaluate. In this article we question the fact of whether they do it in an efficient way. From diagnostic test of pairs of problems (a quantitative and a similar qualitative one) it is shown that many students can solve quantitative problems without an appropriate conceptual comprehension

The edge of the young Galactic disc

In this work we report and discuss the detection of two distant diffuse stellar groups in the third Galactic quadrant. They are composed of young stars, with spectral types ranging from late O to late B, and lie at galactocentric distances between 15 and 20 kpc. These groups are located in the area of two cataloged open clusters (VdB-Hagen~04 and Ruprecht~30), projected towards the Vela-Puppis constellations, and within the core of the Canis Major over-density. Their reddening and distance has been estimated analyzing their color-color and color-magnitude diagrams, derived from deep $UBV$ photometry. The existence of young star aggregates at such extreme distances from the Galactic center challenges the commonly accepted scenario in which the Galactic disc has a sharp cut-off at about 14 kpc from the Galactic center, and indicates that it extends to much greater distances (as also supported by recent detection of CO molecular complexes well beyond this distance). While the groups we find in the area of Ruprecht~30 are compatible with the Orion and Norma-Cygnus spiral arms, respectively, the distant group we identify in the region of VdB-Hagen~4 lies in the external regions of the Norma-Cygnus arm, at a galactocentric distance ($\sim$20 kpc) where no young stars had been detected so far in the optical.Comment: 45 pages, 11 eps figure, accepted for publication in the Astrophysical Journa

Die kondyläre Metastasierung: Literaturrecherche und ein Fallbericht

Zusammenfassung: Hintergrund: Kondyläre Metastasen sind eine Rarität. In der Literaturrecherche entsprachen nur 23 der insgesamt 69 gefundenen Fälle den Kriterien von Meyer u. Shklar. Fallbericht: Bei einem 48-jährigen Mann mit Schmerzen im linken Kiefergelenk wurde im linken Kondylus eine solitäre Metastase eines kurz zuvor operierten Lungenkarzinoms gefunden. Aufgrund der ausgedehnten Umgebungsinfiltration erfolgte eine kurative Radiatio. Im Verlauf traten weitere Skelettmetastasen auf. Diskussion: Kieferköpfchenmetastasen unterscheiden sich bezüglich ihres Verlaufs kaum von den Metastasen des extraartikulären Kieferbereiches. Unter den metastasierenden Tumoren rangiert das Mammakarzinom als Primärtumor an erster Stelle, gefolgt vom Lungenkarzinom. Klinisch und radiologisch können keine spezifischen Parameter für eine Diagnosestellung angegeben werden. Bei der Differenzialdiagnostik der Gelenkserkrankungen sollte jedoch insbesondere bei Patienten mit bekannten Primärtumoren und Gelenksbeschwerden sowie radiologischen Auffälligkeiten eine mögliche Metastasierung berücksichtigt werden. Die Diagnose sollte für eine entsprechende Therapieplanung histologisch gesichert werden. Das therapeutische Vorgehen ist in der Regel palliativ, da die Grunderkrankung bei Diagnosestellung einer Kieferköpfchenmetastase zumeist weit fortgeschritten is

Hypoglycemia in response to glucose and glucagon in insulinoma patients with a negative prolonged fast: Functional and morphological properties

A negative 72-h fast is usually considered to preclude the diagnosis of insulinoma. The aim of this study was to describe the functional and morphological properties of two exceptional patients with an insulinoma who had exhibited pre-operatively a negative 72-h fast. Despite the ability of tumor cells to turn off insulin secretion in response to low plasma glucose during 72 h of fasting, hyperinsulinemic hypoglycemia occurred in both patients in response to stimulation by classical secretagogues. Pre-operatively, both patients underwent oral and iv glucose challenge tests and iv glucagon stimulation test. Insulin secretion was rapidly stimulated by these secretagogues to an exaggerated extent and thereby caused hypoglycemia due to an insulin mass effect. In contrast to the common functional features during suppression and stimulation tests, the tumors differed widely with regard to insulin and proinsulin response to calcium during ASVS tests and morphological properties. In patient 1, the immunohistochemical proinsulin distribution pattern resembled that of normal γ-cells, i.e. the staining was restricted to the perinuclear area; insulin and proinsulin were not stimulated by calcium during the ASVS test. In patient 2, the proinsulin staining pattern was abnormal, i.e. proinsulin was also found in the periphery of tumor cells; insulin and proinsulin were stimulated by calcium. We conclude that normal or exaggerated rather than defective glucose sensing may explain hypoglycemia in these exceptional insulinoma patients. Different functional characteristics of these tumors can be correlated with distinct morphological propertie