Do diacritics entail an early processing cost in the absence of abstract representations? Evidence from masked priming in English

Using the masked priming technique, word recognition experiments in various languages have shown slower response times for a target word like NEVEU (nephew, in French) when preceded by a diacritical prime like néveu than by the identity prime neveu. The most common account of this effect is linguistic: diacritical and non-diacritical vowels (e.g., é and e) activate different letter representations (e.g., compare neveu /nə.vø/ vs. néveu /ne.vø/). However, another explanation is that the reduced effectiveness of the diacritical primes is merely due to the perceptual salience of accent marks in the first moments of word processing. Here, we designed a masked priming experiment that tested this perceptual salience account by comparing the effectiveness of diacritical versus non-diacritical primes in a language where diacritics have no linguistic value, namely, English (e.g., nórth-NORTH vs. north-NORTH). We found a small but reliable cost due to the diacritical primes, thus revealing that perceptual salience reduced the effectiveness of the primes. However, the effect sizes were substantially smaller than in the experiments in languages with diacritical marks, thus suggesting that the néveu-NEVEU versus neveu-NEVEU difference relies on both linguistic and perceptual sources

The anterior-posterior axis emerges respecting the morphology of the mouse embryo that changes and aligns with the uterus before gastrulation

Background: When the anterior-posterior axis of the mouse embryo becomes explicit at gastrulation, it is almost perpendicular to the long uterine axis. This led to the belief that the uterus could play a key role in positioning this future body axis. Results: Here, we demonstrate that when the anterior-posterior axis first emerges it does not respect the axes of the uterus but, rather, the morphology of the embryo. Unexpectedly, the emerging anterior-posterior axis is initially aligned not with the long, but the short axis of the embryo. Then whether the embryo develops in vitro or in utero, the anterior-posterior axis becomes aligned with the long axis of embryo just prior to gastrulation. Of three mechanisms that could account for this apparent shift in anterior-posterior axis orientation-cell migration, spatial change of gene expression, or change in embryo shape-lineage tracing studies favor a shape change accompanied by restriction of the expression domain of anterior markers. This property of the embryo must be modulated by interactions with the uterus as ultimately the anterior-posterior and long axes of the embryo align with the left-right uterine axis. Conclusions: The emerging anterior-posterior axis relates to embryo morphology rather than that of the uterus. The apparent shift in its orientation to align with the long embryonic axis and with the uterus is associated with a change in embryo shape and a refinement of anterior gene expression pattern. This suggests an interdependence between anterior-posterior gene expression, the shape of the embryo, and the uterus.Wellcome Trust [064421]info:eu-repo/semantics/publishedVersio

Letter-similarity effects in braille word recognition.

Letter-similarity effects are elusive with common words in lexical decision experiments: viotin and viocin (base word: violin) produce similar error rates and rejection latencies. However, they are robust for stimuli often presented with the same appearance (e.g., misspelled logotypes such as anazon [base word: amazon] produce more errors and longer latencies than atazon). Here, we examine whether letter-similarity effects occur in reading braille. The rationale is that braille is a writing system in which the sensory information is processed in qualitatively different ways than in visual reading: the form of the word's letters is highly stable due to the standardization of braille and the sensing of characters is transient and somewhat serial. Hence, we hypothesized that the letter similarity effect would be sizeable with misspelled common words in braille, unlike the visual modality. To test this hypothesis, we conducted a lexical decision experiment with blind adult braille readers. Pseudowords were created by replacing one letter of a word with a tactually-similar or dissimilar letter in braille following a tactile similarity matrix (Baciero et al., 2021a; e.g., [ausor] vs. [aucor]; baseword: [autor]). Bayesian linear mixed-effects models showed that the responses to tactually-similar pseudowords were less accurate than to tactually-dissimilar pseudowords-the RTs showed a parallel trend. This finding supports the idea that, when reading braille, the mapping of input information onto abstract letter representations is done through a noisy channel (Norris & Kinoshita, 2012)

Do grading gray stimuli help to encode letter position?

Numerous experiments in the past decades recurrently showed that a transposed-letter pseudoword (e.g., JUGDE) is much more wordlike than a replacement-letter control (e.g., JUPTE). Critically, there is an ongoing debate as to whether this effect arises at a perceptual level (e.g., perceptual uncertainty at assigning letter position of an array of visual objects) or at an abstract language-specific level (e.g., via a level of “open bigrams” between the letter and word levels). Here, we designed an experiment to test the limits of perceptual accounts of letter position coding. The stimuli in a lexical decision task were presented either with a homogeneous letter intensity or with a graded gray intensity, which indicated an unambiguous letter order. The pseudowords were either transposed-letter pseudowords or replaced-letter pseudowords (e.g., jugde vs. jupte). The results showed much longer response times and substantially more errors in the transposedletter pseudowords than in the replacement-letter pseudowords, regardless of visual format. These findings favor the idea that language-specific orthographic element factors play an essential role when encoding letter position during word recognition

Goosecoid and HNF-3beta genetically interact to regulate neural tube patterning during mouse embryogenesis

The homeobox gene goosecoid (gsc) and the winged-helix gene Hepatic Nuclear Factor-3beta (HNF-3beta) are co-expressed in all three germ layers in the anterior primitive streak and at the rostral end of mouse embryos during gastrulation. In this paper, we have tested the possibility of functional synergism or redundancy between these two genes during embryogenesis by generating double-mutant mice for gsc and HNF-3beta. Double-mutant embryos of genotype gsc(-/-);HNF-3beta(+/-) show a new phenotype as early as embryonic days 8.75. Loss of Sonic hedgehog (Shh) and HNF-3beta expression was observed in the notochord and ventral neural tube of these embryos. These results indicate that gsc and HNF-3beta interact to regulate Shh expression and consequently dorsal-ventral patterning in the neural tube. In the forebrain of the mutant embryos, severe growth defects and absence of optic vesicles could involve loss of expression of fibroblast growth factor-8, in addition to Shh. Our results also suggest that interaction between gsc and HNF-3beta regulates other signalling molecules required for proper development of the foregut, branchial arches and heart

Initiating head development in mouse embryos: integrating signalling and transcriptional activity

The generation of an embryonic body plan is the outcome of inductive interactions between the progenitor tissues that underpin their specification, regionalization and morphogenesis. The intercellular signalling activity driving these processes is deployed in a time- and site-specific manner, and the signal strength must be precisely controlled. Receptor and ligand functions are modulated by secreted antagonists to impose a dynamic pattern of globally controlled and locally graded signals onto the tissues of early post-implantation mouse embryo. In response to the WNT, Nodal and Bone Morphogenetic Protein (BMP) signalling cascades, the embryo acquires its body plan, which manifests as differences in the developmental fate of cells located at different positions in the anterior–posterior body axis. The initial formation of the anterior (head) structures in the mouse embryo is critically dependent on the morphogenetic activity emanating from two signalling centres that are juxtaposed with the progenitor tissues of the head. A common property of these centres is that they are the source of antagonistic factors and the hub of transcriptional activities that negatively modulate the function of WNT, Nodal and BMP signalling cascades. These events generate the scaffold of the embryonic head by the early-somite stage of development. Beyond this, additional tissue interactions continue to support the growth, regionalization, differentiation and morphogenesis required for the elaboration of the structure recognizable as the embryonic head

Molecular Characterization of the Gastrula in the Turtle Emys orbicularis: An Evolutionary Perspective on Gastrulation

Due to the presence of a blastopore as in amphibians, the turtle has been suggested to exemplify a transition form from an amphibian- to an avian-type gastrulation pattern. In order to test this hypothesis and gain insight into the emergence of the unique characteristics of amniotes during gastrulation, we have performed the first molecular characterization of the gastrula in a reptile, the turtle Emys orbicularis. The study of Brachyury, Lim1, Otx2 and Otx5 expression patterns points to a highly conserved dynamic of expression with amniote model organisms and makes it possible to identify the site of mesoderm internalization, which is a long-standing issue in reptiles. Analysis of Brachyury expression also highlights the presence of two distinct phases, less easily recognizable in model organisms and respectively characterized by an early ring-shaped and a later bilateral symmetrical territory. Systematic comparisons with tetrapod model organisms lead to new insights into the relationships of the blastopore/blastoporal plate system shared by all reptiles, with the blastopore of amphibians and the primitive streak of birds and mammals. The biphasic Brachyury expression pattern is also consistent with recent models of emergence of bilateral symmetry, which raises the question of its evolutionary significance