Superfluid Friction and Late-time Thermal Evolution of Neutron Stars

The recent temperature measurements of the two older isolated neutron stars PSR 1929+10 and PSR 0950+08 (ages of $3\times 10^6$ and $2\times 10^7$ yr, respectively) indicate that these objects are heated. A promising candidate heat source is friction between the neutron star crust and the superfluid it is thought to contain. We study the effects of superfluid friction on the long-term thermal and rotational evolution of a neutron star. Differential rotation velocities between the superfluid and the crust (averaged over the inner crust moment of inertia) of $\bar\omega\sim 0.6$ rad s$^{-1}$ for PSR 1929+10 and $\sim 0.02$ rad s$^{-1}$ for PSR 0950+08 would account for their observed temperatures. These differential velocities could be sustained by pinning of superfluid vortices to the inner crust lattice with strengths of $\sim$ 1 MeV per nucleus. Pinned vortices can creep outward through thermal fluctuations or quantum tunneling. For thermally-activated creep, the coupling between the superfluid and crust is highly sensitive to temperature. If pinning maintains large differential rotation ($\sim 10$ rad s$^{-1}$), a feedback instability could occur in stars younger than $\sim 10^5$ yr causing oscillations of the temperature and spin-down rate over a period of $\sim 0.3 t_{\rm age}$. For stars older than $\sim 10^6$ yr, however, vortex creep occurs through quantum tunneling, and the creep velocity is too insensitive to temperature for a thermal-rotational instability to occur. These older stars could be heated through a steady process of superfluid friction.Comment: 26 pages, 1 figure, submitted to Ap

Bounds on the diameter of Cayley graphs of the symmetric group

In this paper we are concerned with the conjecture that, for any set of generators S of the symmetric group of degree n, the word length in terms of S of every permutation is bounded above by a polynomial of n. We prove this conjecture for sets of generators containing a permutation fixing at least 37% of the points.Comment: 17 pages, 6 table

Pilus distribution among lineages of group b <i>streptococcus</i>: an evolutionary and clinical perspective

&lt;b&gt;Background&lt;/b&gt;&lt;p&gt;&lt;/p&gt; Group B Streptococcus (GBS) is an opportunistic pathogen in both humans and bovines. Epidemiological and phylogenetic analyses have found strains belonging to certain phylogenetic lineages to be more frequently associated with invasive newborn disease, asymptomatic maternal colonization, and subclinical bovine mastitis. Pilus structures in GBS facilitate colonization and invasion of host tissues and play a role in biofilm formation, though few large-scale studies have estimated the frequency and diversity of the three pilus islands (PIs) across diverse genotypes. Here, we examined the distribution of pilus islands (PI) 1, 2a and 2b among 295 GBS strains representing 73 multilocus sequence types (STs) belonging to eight clonal complexes. PCR-based RFLP was also used to evaluate variation in the genes encoding pilus backbone proteins of PI-2a and PI-2b.&lt;p&gt;&lt;/p&gt; &lt;b&gt;Results&lt;/b&gt;&lt;p&gt;&lt;/p&gt; All 295 strains harbored one of the PI-2 variants and most human-derived strains contained PI-1. Bovine-derived strains lacked PI-1 and possessed a unique PI-2b backbone protein allele. Neonatal strains more frequently had PI-1 and a PI-2 variant than maternal colonizing strains, and most CC-17 strains had PI-1 and PI-2b with a distinct backbone protein allele. Furthermore, we present evidence for the frequent gain and loss of genes encoding certain pilus types.&lt;p&gt;&lt;/p&gt; &lt;b&gt;Conclusions&lt;/b&gt;&lt;p&gt;&lt;/p&gt; These data suggest that pilus combinations impact host specificity and disease presentation and that diversification often involves the loss or acquisition of PIs. Such findings have implications for the development of GBS vaccines that target the three pilus islands

Capoeira for beginners: self-benefit for, and community action by, new Capoeiristas

Capoeira could be defined as a Brazilian martial art and game to be played. This research explored how capoeira play might be considered to facilitate connectedness amongst newly-recruited persons, plus any other ramifications of capoeira involvement. A beginners’ course of capoeira was provided to participants, free of charge, in an English city in the West Midlands—new capoeiristas in a new venue for capoeira. Researchers attended classes to collect/construct overt non-participant observation data. In addition, semi-structured interviews were undertaken with the new capoeiristas post-course. This article explores researchers’ observation fieldnotes and interviewees’ narratives. These qualitative data-driven debates include the concepts: self, identity, escapism, multiparty endeavour, community, temporality, enjoyment, and transcending boundaries. Capoeira is theorised in a fresh manner that highlights social benefits of capoeira—for example as an enjoyable and supportive group endeavour which includes elements of social play and community-building—plus benefits for self that can transcend the boundaries of the class. Findings highlight how capoeira can be considered an inherently multiparty endeavour whereby social actors form, and experience, a community in order to embrace capoeira play. Data suggest capoeira can facilitate group playfulness, joviality, and laughter. Further, capoeiristas can enact and experience—some mode of—escapism via capoeira, whereby new place and pursuit can facilitate hedonistic diversion from the mundane. Capoeira appears to provide adventure and liberation into a relatively unburdened part of, or place in, social life. Corporeal and discursive boundary-empowerment can also be experienced by capoeiristas, fostering positive identity work in the wider world. Capoeira can be argued to facilitate mutuality (e.g. community experience and group work) and egoism (e.g. an individual's identity work) concurrently. This research suggests that modified capoeira for beginners can be beneficial for both the new capoeiristas themselves and for positive community action during and beyond class

New Dimensions for Wound Strings: The Modular Transformation of Geometry to Topology

We show, using a theorem of Milnor and Margulis, that string theory on compact negatively curved spaces grows new effective dimensions as the space shrinks, generalizing and contextualizing the results in hep-th/0510044. Milnor's theorem relates negative sectional curvature on a compact Riemannian manifold to exponential growth of its fundamental group, which translates in string theory to a higher effective central charge arising from winding strings. This exponential density of winding modes is related by modular invariance to the infrared small perturbation spectrum. Using self-consistent approximations valid at large radius, we analyze this correspondence explicitly in a broad set of time-dependent solutions, finding precise agreement between the effective central charge and the corresponding infrared small perturbation spectrum. This indicates a basic relation between geometry, topology, and dimensionality in string theory.Comment: 28 pages, harvmac big. v2: references and KITP preprint number added, minor change

Adiabatic quantum algorithm for search engine ranking

We propose an adiabatic quantum algorithm for generating a quantum pure state encoding of the PageRank vector, the most widely used tool in ranking the relative importance of internet pages. We present extensive numerical simulations which provide evidence that this algorithm can prepare the quantum PageRank state in a time which, on average, scales polylogarithmically in the number of webpages. We argue that the main topological feature of the underlying web graph allowing for such a scaling is the out-degree distribution. The top ranked $\log(n)$ entries of the quantum PageRank state can then be estimated with a polynomial quantum speedup. Moreover, the quantum PageRank state can be used in "q-sampling" protocols for testing properties of distributions, which require exponentially fewer measurements than all classical schemes designed for the same task. This can be used to decide whether to run a classical update of the PageRank.Comment: 7 pages, 5 figures; closer to published versio

Collapse of Stiff Polyelectrolytes due to Counterion Fluctuations

The effective elasticity of highly charged stiff polyelectrolytes is studied in the presence of counterions, with and without added salt. The rigid polymer conformations may become unstable due to an effective attraction induced by counterion density fluctuations. Instabilities at the longest, or intermediate length scales may signal collapse to globule, or necklace states, respectively. In the presence of added-salt, a generalized electrostatic persistence length is obtained, which has a nontrivial dependence on the Debye screening length.Comment: 4 pages RevTex, 3 ps figures included using epsf, final version as appeared in PR

Study protocol for a multicentre longitudinal mixed methods study to explore the Outcomes of ChildrEn and fAmilies in the first year after paediatric Intensive Care: the OCEANIC study.

INTRODUCTION: Annually in the UK, 20 000 children become very ill or injured and need specialist care within a paediatric intensive care unit (PICU). Most children survive. However, some children and their families may experience problems after they have left the PICU including physical, functional and/or emotional problems. It is unknown which children and families experience such problems, when these occur or what causes them. The aim of this mixed-method longitudinal cohort study is to understand the physical, functional, emotional and social impact of children surviving PICU (aged: 1 month-17 years), their parents and siblings, during the first year after a PICU admission. METHODS AND ANALYSIS: A quantitative study involving 300 child survivors of PICU; 300 parents; and 150-300 siblings will collect data (using self-completion questionnaires) at baseline, PICU discharge, 1, 3, 6 and 12 months post-PICU discharge. Questionnaires will comprise validated and reliable instruments. Demographic data, PICU admission and treatment data, health-related quality of life, functional status, strengths and difficulties behaviour and post-traumatic stress symptoms will be collected from the child. Parent and sibling data will be collected on the impact of paediatric health conditions on the family's functioning capabilities, levels of anxiety and social impact of the child's PICU admission. Data will be analysed using descriptive and inferential statistics. Concurrently, an embedded qualitative study involving semistructured interviews with 24 enrolled families at 3 months and 9 months post-PICU discharge will be undertaken. Framework analysis will be used to analyse the qualitative data. ETHICS AND DISSEMINATION: The study has received ethical approval from the National Health Services Research Ethics Committee (Ref: 19/WM/0290) and full governance clearance. This will be the first UK study to comprehensively investigate physical, functional, emotional and social consequences of PICU survival in the first-year postdischarge.Clinical Trials Registration Number: ISRCTN28072812 [Pre-results]

Classification of protein interaction sentences via gaussian processes

The increase in the availability of protein interaction studies in textual format coupled with the demand for easier access to the key results has lead to a need for text mining solutions. In the text processing pipeline, classification is a key step for extraction of small sections of relevant text. Consequently, for the task of locating protein-protein interaction sentences, we examine the use of a classifier which has rarely been applied to text, the Gaussian processes (GPs). GPs are a non-parametric probabilistic analogue to the more popular support vector machines (SVMs). We find that GPs outperform the SVM and na\"ive Bayes classifiers on binary sentence data, whilst showing equivalent performance on abstract and multiclass sentence corpora. In addition, the lack of the margin parameter, which requires costly tuning, along with the principled multiclass extensions enabled by the probabilistic framework make GPs an appealing alternative worth of further adoption

Low mortality of people living with diabetes mellitus diagnosed with COVID-19 and managed at a field hospital in Western Cape Province, South Africa

Background. The novel coronavirus disease 2019 (COVID-19) was declared an international pandemic by the World Health Organization in March 2020. Throughout the pandemic, the association between diabetes mellitus (DM) and more severe COVID-19 has been well described internationally, with limited data, however, on South Africa (SA). The role of field hospitals in the management of patients with COVID-19 in SA has not yet been described. Objectives. To describe the mortality and morbidity of people living with DM (PLWD) and comorbid COVID-19, as well as to shed light on the role of intermediate facilities in managing DM and COVID-19 during the pandemic. Methods. This is a single-centre cross-sectional descriptive study that included all patients with confirmed COVID-19 and pre-existing or newly diagnosed DM (of any type) admitted to the Cape Town International Convention Centre (CTICC) Intermediate Care Bed Facility from June 2020 to August 2020. This study presents the profile of patients admitted to the CTICC, and reports on the clinical outcome of PLWD diagnosed with COVID-19, and additionally determines some associations between risk factors and death or escalation of care in this setting. Results. There were 1 447 admissions at the CTICC, with a total of 674 (46.6%) patients who had confirmed DM, of whom 125 (19%) were newly diagnosed diabetics and 550 (81%) had pre-existing DM. Included in this group were 57 referrals from the telemedicine platform – a platform that identified high-risk diabetic patients with COVID-19 in the community, and linked them directly to hospital inpatient care. Of the 674 PLWD admitted, 593 were discharged alive, 45 were escalated to tertiary hospital requiring advanced care and 36 died. PLWD who died were older, had more comorbidities (specifically chronic obstructive pulmonary disease, congestive cardiac failure and chronic kidney disease) and were more likely to be on insulin.Conclusions. In a resource-limited environment, interdisciplinary and interfacility collaboration ensured that complicated patients with DM and COVID-19 were successfully managed in a field hospital setting. Telemedicine offered a unique opportunity to identify high-risk patients in the community and link them to in-hospital monitoring and care. Future studies should explore ways to optimise this collaboration, as well as to explore possibilities for early identification and management of high-risk patients