Aspergiloma primário e aspergilose invasiva subaguda em dois pacientes com AIDS

Although uncommon, invasive aspergillosis in the setting of AIDS is important because of its peculiar clinical presentation and high lethality. This report examines two AIDS patients with a history of severe cellular immunosuppression and previous neutropenia, who developed subacute invasive aspergillosis. One female patient developed primary lung aspergilloma, with dissemination to the mediastinum, vertebrae, and spine, which was fatal despite antifungal treatment. The second patient, who had multiple cavitary brain lesions, and eye and lung involvement, recovered following voriconazole and itraconazole, and drugs for increasing neutrophil and CD4+ lymphocyte levels. These cases demonstrate the importance of Aspergillus infections following neutropenia in AIDS patients, and emphasize the need for early and effective antifungal therapy.A aspergilose invasiva em pacientes com aids, embora incomum, é relevante pela apresentação clínica peculiar e alta letalidade. Este relato descreve os casos de dois pacientes com aids com grave imunossupressão celular e neutropenia prévia, os quais tiveram aspergiloma pulmonar primário, com disseminação para mediastino, vértebras e medula espinhal, evoluindo para óbito apesar do tratamento antifúngico. O segundo paciente, que tinha lesões cavitárias múltiplas no cérebro e infecção ocular e pulmonar, recuperou-se após tratamento com voricanazol, itraconazol e com drogas para aumentar o número de neutrófilos e de linfócitos CD4+. Estes casos demonstram o risco de infecção por Aspergillus após episódios de neutropenia em pacientes com aids e alertam para o início precoce de terapia antifúngica eficaz

Especies de Mycosphaerella y Teratosphaeria asociadas con la enfermedad Mycosphaerella de las hojas en Eucalyptus globulus en Portugal

Plantations of Eucalyptus globulus represent the main source of wood for the pulp and paper industry in Portugal and are affected by the complex of Mycosphaerella and Teratosphaeria species (Mycosphaerella leaf disease), which is an important foliage disease worldwide. This disease affect mainly young trees with juvenile-phase foliage, causing premature defoliation, decreased growth and wood production. Species of Mycosphaerella sensu lato reported on eucalypts in Portugal are M. communis, M. heimii, M. lateralis, M. madeirae, M. marksii M. walkeri, T. africana, T. molleriana, T. nubilosa and T. parva. In order to complete the survey, symptomatic leaves were collected from Eucalyptus globulus plantations. Morphological and molecular characterization was used to give an indication of the species occurrence and most frequent species (T. nubilosa) and the composition of the MLD complex that did not change after the latest review.Las plantaciones de Eucalyptus globulus representan la principal fuente de madera para la industria de pasta y papel en Portugal y se ven afectadas por el complejo de especies de Mycosphaerella y Teratosphaeria (enfermedad Mycosphaerella de las hojas), que es una enfermedad importante en todo el mundo. Esta enfermedad afecta principalmente a los árboles con fase juvenil de follaje, causando defoliación prematura, disminución del crecimiento y de producción de madera. Las especies de Mycosphaerella sensu lato descritas sobre el eucalipto en Portugal son M. communis, M. heimii, M. lateral, M. madeirae, M. marksii, M walkeri, T. africana, T. molleriana, T. nubilosa y T. parva. Con el fin de completar el inventario, se obtuvieron hojas sintomáticas de plantaciones de Eucalyptus globulus. Se ha utilizado una caracterización morfológica y molecular para identificar la presencia de especies, la especie más frecuente (T. nubilosa) y la composición del complejo de MLD que no cambió después de esta última revisión

Prevention of nasal trauma due to CPAP in a preterm newborn: case report

The administration of continuous positive airway pressure through nasal CPAP has been used in the treatment of neonatal respiratory diseases as a means of providing ventilatory support to preterm infants, producing adequate gas exchange, decreasing the complications induced by invasive mechanical ventilation and reducing bronchopulmonary dysplasia. The nasal prong is the most common device used to connect to the airways with the purpose of providing mechanical ventilation. Nasal prongs are available in different sizes and made of lightweight and flexible material. Despite its advantages, this device can cause trauma to the nose causing nasal discomfort and disfigurement. We report the case of an extremely low birth weight preterm who used a system of nasal CPAP developed by the nurses of the Neonatal Intensive Care Unit of the HCPA to protect the skin, mucosa, and nasal septum. Protection was successful

Development of iridium porphyrin arrays by axial coordination trough N-bidentate ligand: Synthesis and evaluation of the optical, electrochemical and thermal properties

Several organic compounds have been used in optoelectronics devices; porphyrins, due to their interesting optical and electronic properties, have shown an attractive potential to be used on molecular electronics. Among other advantages, porphyrins easily coordinate with several metal ions, which allows the assembly with peripheral or axial ligands introducing new properties to the supramolecular porphyrin. In this work, a new metalloporphyrin system with 5,10,15,20-(tetra-p-tolyl)porphyrin (ttp) and iridium(III) where 4,4’-bipyridine (bpy) coordinate in the axial positions was successfully synthetized, through the formation of “shish kebab” structures. This new compound was characterized through ultraviolet-visible, proton nuclear magnetic resonance, Fourier-transform infrared and Raman spectroscopies, thermogravimetry, differential scanning calorimeter and cyclic voltammetry. The introduction of the bpy on the metalloporphyrin moiety exhibited important influence on the optical, thermal and electrochemical properties.The authors acknowledge the Portuguese Foundation of Science and Technology (TSSiPRO – TECHNOLOGIES FOR SUSTAINABLE AND SMART INNOVATIVE PRODUCTS – NORTE-01-0145-FEDER-000015) and UID/CTM/50025/2013 for the financial support.info:eu-repo/semantics/publishedVersio

Carvão vegetal como condicionador de solo para arroz de terras altas (cultivar Primavera): um estudo prospectivo.

O objetivo deste trabalho foi demonstrar o efeito do fino do carvão de eucalipto (Eucalyptus sp.) nas variáveis de fertilidade e propriedades físicas do solo considerando-se o crescimento e desenvolvimento do arroz de terras altas (cultivar Primavera).bitstream/CNPAF/25441/1/comt_125.pd

Trends in method-specific suicide in Brazil from 2000 to 2017

Purpose: Understanding long-term patterns of suicide methods can inform public health policy and prevention strategies. In Brazil, firearm-related policies may be one salient target for suicide prevention. This study describes trends in method-specific suicide at the national and state-levels in Brazil, with a particular focus on firearm-related suicides. / Methods: Brazilian mortality data for suicide and undetermined intent among people aged 10 years and older between 2000 and 2017 were obtained from the National Mortality Information System. We examined national and state-level trends in age-standardised suicide rates for hanging, self-poisoning, firearms, jumping from a high place, other, and unspecified methods. We also compared total rates of mortality from suicide and undetermined intent over the period. Applying Joinpoint regression, we tested changes in trends of firearm-specific suicide rates. / Results: The total suicide rate increased between 2000 and 2017. Rates of hanging, self-poisoning by drugs or alcohol and jumping from a high place showed the largest increases, while firearm-specific suicide rates decreased over the study period. Trends in methods of suicide varied by sex and state. / Conclusion: It is of public health concern that suicide rates in Brazil have risen this millennium. Restricting access to firearms might be an effective approach for reducing firearm-specific suicides, especially in states where firearm availability remains particularly high. Treatment and management of substance misuse may also be an important target for suicide prevention policies. More work is needed to understand the causes of rising suicide rates in Brazil and to improve the mental health of the population

Dibucaine in Ionic-Gradient Liposomes: Biophysical, Toxicological, and Activity Characterization

Administration of local anesthetics is one of the most effective pain control techniques for postoperative analgesia. However, anesthetic agents easily diffuse into the injection site, limiting the time of anesthesia. One approach to prolong analgesia is to entrap local anesthetic agents in nanostructured carriers (e.g., liposomes). Here, we report that using an ammonium sulphate gradient was the best strategy to improve the encapsulation (62.6%) of dibucaine (DBC) into liposomes. Light scattering and nanotracking analyses were used to characterize vesicle properties, such as, size, polydispersity, zeta potentials, and number. In vitro kinetic experiments revealed the sustained release of DBC (50% in 7 h) from the liposomes. In addition, in vitro (3T3 cells in culture) and in vivo (zebrafish) toxicity assays revealed that ionic-gradient liposomes were able to reduce DBC cyto/cardiotoxicity and morphological changes in zebrafish larvae. Moreover, the anesthesia time attained after infiltrative administration in mice was longer with encapsulated DBC (27 h) than that with free DBC (11 h), at 320 μM (0.012%), confirming it as a promising long-acting liposome formulation for parenteral drug administration of dibucaine.Fil: Couto, Verônica M.. Universidade Estadual de Campinas; BrasilFil: Prieto, Maria Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología-Universidad Nacional de Quilmes - GBEyB | Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología-Universidad Nacional de Quilmes - GBEyB | Universidad Nacional de la Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología-Universidad Nacional de Quilmes - GBEyB; ArgentinaFil: Igartúa, Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología-Universidad Nacional de Quilmes - GBEyB | Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología-Universidad Nacional de Quilmes - GBEyB | Universidad Nacional de la Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología-Universidad Nacional de Quilmes - GBEyB; ArgentinaFil: Feas, Daniela Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología-Universidad Nacional de Quilmes - GBEyB | Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología-Universidad Nacional de Quilmes - GBEyB | Universidad Nacional de la Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología-Universidad Nacional de Quilmes - GBEyB; ArgentinaFil: Ribeiro, Lígia N.M.. Universidade Estadual de Campinas; BrasilFil: Silva, Camila M.G.. Universidade Estadual de Campinas; BrasilFil: Castro, Simone R.. Universidade Estadual de Campinas; BrasilFil: Guilherme, Viviane A.. Universidade Estadual de Campinas; BrasilFil: Dantzger, Darlene D.. Universidade Estadual de Campinas; BrasilFil: Machado, Daisy. Universidade Estadual de Campinas; BrasilFil: Alonso, Silvia del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología-Universidad Nacional de Quilmes - GBEyB | Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología-Universidad Nacional de Quilmes - GBEyB | Universidad Nacional de la Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología-Universidad Nacional de Quilmes - GBEyB; ArgentinaFil: de Paula, Eneida. Universidade Estadual de Campinas; Brasi

Induction, growth kinetics and morpho-histological characterization of Neem callus.

Made available in DSpace on 2018-12-29T23:30:18Z (GMT). No. of bitstreams: 1 Induction.pdf: 1077915 bytes, checksum: b36bbc67ad6fd1d0dad6b6f771adac82 (MD5) Previous issue date: 2018-12-28bitstream/item/189499/1/Induction.pd