Applications of percolation theory to fungal spread with synergy

There is increasing interest in the use of the percolation paradigm to analyze and predict the progress of disease spreading in spatially-structured populations of animals and plants. The wider utility of the approach has been limited, however, by several restrictive assumptions, foremost of which is a strict requirement for simple nearest-neighbour transmission, in which the disease history of an individual is in uenced only by that of its neighbours. In a recent paper the percolation paradigm has been generalised to incorporate synergistic interactions in host infectivity and susceptibility and the impact of these interactions on the invasive dynamics of an epidemic has been demonstrated. In the current paper we elicit evidence that such synergistic interactions may underlie transmission dynamics in real-world systems by rst formulating a model for the spread of a ubiquitous parasitic and saprotrophic fungus through replicated populations of nutrient sites and subsequently tting and testing the model using data from experimental microcosms. Using Bayesian computational methods for model tting, we demonstrate that synergistic interactions are necessary to explain the dynamics observed in the replicate experiments. The broader implications of this work in identifying disease control strategies that de ect epidemics from invasive to non-invasive regimes are discussed

Relativistic Disk Reflection in the Neutron Star X-ray Binary XTE J1709-267 with NuSTAR

We perform the first reflection study of the soft X-ray transient and Type 1 burst source XTE J1709-267 using NuSTAR observations during its 2016 June outburst. There was an increase in flux near the end of the observations, which corresponds to an increase from $\sim$0.04 L$_{\mathrm{Edd}}$ to $\sim$0.06 L$_{\mathrm{Edd}}$ assuming a distance of 8.5 kpc. We have separately examined spectra from the low and high flux intervals, which were soft and show evidence of a broad Fe K line. Fits to these intervals with relativistic disk reflection models have revealed an inner disk radius of $13.8_{-1.8}^{+3.0}\ R_{g}$ (where $R_{g} = GM/c^{2}$) for the low flux spectrum and $23.4_{-5.4}^{+15.6}\ R_{g}$ for the high flux spectrum at the 90\% confidence level. The disk is likely truncated by a boundary layer surrounding the neutron star or the magnetosphere. Based on the measured luminosity and using the accretion efficiency for a disk around a neutron star, we estimate that the theoretically expected size for the boundary layer would be $\sim0.9-1.1 \ R_{g}$ from the neutron star's surface, which can be increased by spin or viscosity effects. Another plausible scenario is that the disk could be truncated by the magnetosphere. We place a conservative upper limit on the strength of the magnetic field at the poles, assuming $a_{*}=0$ and $M_{NS}=1.4\ M_{\odot}$, of $B\leq0.75-3.70\times10^{9}$ G, though X-ray pulsations have not been detected from this source.Comment: Accepted for publication in ApJ, 5 pages, 4 figures, 1 table. arXiv admin note: text overlap with arXiv:1701.0177

X-ray Spectral and Variability Properties of Low-Mass AGN

We study the X-ray properties of a sample of 14 optically-selected low-mass AGN whose masses lie within the range 1E5 -2E6 M(solar) with XMM-Newton. Only six of these low-mass AGN have previously been studied with sufficient quality X-ray data, thus, we more than double the number of low-mass AGN observed by XMM-Newton with the addition of our sample. We analyze their X-ray spectral properties and variability and compare the results to their more massive counterparts. The presence of a soft X-ray excess is detectable in all five objects which were not background dominated at 2-3 keV. Combined with previous studies, this gives a total of 8 low-mass AGN with a soft excess. The low-mass AGN exhibit rapid, short-term variability (hundreds to thousands of seconds) as well as long-term variability (months to years). There is a well-known anti-correlation between black hole mass and variability amplitude (normalized excess variance). Comparing our sample of low-mass AGN with this relation we find that all of our sample lie below an extrapolation of the linear relation. Such a flattening of the relation at low masses (below about 1E6 M(solar)) is expected if the variability in all AGN follows the same shape power spectrum with a break frequency that is dependent on mass. Finally, we also found two objects that show significant absorption in their X-ray spectrum, indicative of type 2 objects, although they are classified as type 1 AGN based on optical spectra.Comment: 12 pages, 5 figures, 7 tables, accepted for publication in MNRA

Optimal electromagnetic energy extraction from transverse galloping

A fully coupled electro-fluid-elastic model for electromagnetic energy harvesting from Transverse Galloping is presented here. The model considers a one degree-of-freedom galloping oscillator where fluid forces are described resorting to quasi-steady conditions; the electromagnetic generator is modelled by an equivalent electrical circuit where power is dissipated at an electrical load resistance; the galloping oscillator and the electromagnetic model are coupled appropriately. Two different levels of simplification have been made depending on the comparison between the characteristic electrical and mechanical timescales. The effect of the electrical resistance load on the energy harvested is studied theoretically. For fixed geometry and mechanical parameters, it has been found that there exists an optimal electrical resistance load for each reduced velocity. On the practical side, this result can be helpful to design tracking-point strategies to maximize energy harvesting for variable flow velocity conditions

Enhanced mechanical energy extraction from transverse galloping using a dual mass system

This paper offers a theoretical study of energy extraction through transverse galloping using a dual-mass system. To this end, a two-degree-of-freedom model is developed where fluid forces on the galloping body are described resorting to quasi-steady hypothesis; the model is solved approximately by using the Harmonic Balance Method. Three possible configurations of the dual-mass system have been analyzed. Two of them show an improvement in the efficiency of energy extraction with respect to that of the single mass configuration when the mechanical properties of the dual-mass system are appropriately chosen. In addition, the dual-mass system promotes a broadening of the values of the incident flow velocities at which the efficiency is kept high

Stimulants for enhancement purposes: perceptions attitudes, usage among university students

Objective: Determine perceptions, attitudes, and usage of non medical prescription stimulants among students at a Midwestern technology focused university. Participants: 241 university students. Methods: Data was collected in March 2015 through an anonymous web survey. A logistic regression model evaluated predictors. T-test was used to evaluate differences between groups. Results: 9.5% had used prescription stimulants without a valid prescription. Primary motives were academic preparation (78%) and recreation (61%). Nicotine use (OR = 8.99, CI 2.40, 33.77, p \u3c .01), peer\u27s suggestion (OR = 6.95, C12.21, 21.84, p \u3c .01), and positive attitudes toward use (OR = 1.99, CI 1.06, 3.72, p \u3c .05) increased odds of nonmedical use. Users and non-users differed in estimations of nonmedical use within peers (t (239) = 3.17, p \u3c .01) and in their field (t (239) = 3.22, p \u3c .01). Conclusions: Administrators should acknowledge student use and develop strategies to address it

Clinical perspectives of emerging pathogens in bleeding disorders.

As a result of immunological and nucleic-acid screening of plasma donations for transfusion-transmissible viruses, and the incorporation of viral reduction processes during plasma fractionation, coagulation-factor concentrates (CFC) are now judged safe in terms of many known infectious agents, including hepatitis B and C viruses, HIV, and human T-cell lymphotropic virus. However, emerging pathogens could pose future threats, particularly those with blood-borne stages that are resistant to viral-inactivation steps in the manufacturing process, such as non-lipid-coated viruses. As outlined in this Review, better understanding of infectious diseases allows challenges from newly described agents of potential concern in the future to be anticipated, but the processes of zoonotic transmission and genetic selection or modification ensure that plasma-derived products will continue to be subject to infectious concerns. Manufacturers of plasma-derived CFC have addressed the issue of emerging infectious agents by developing recombinant products that limit the need for human plasma during production. Such recombinant products have extended the safety profile of their predecessors by ensuring that all reagents used for cell culture, purification steps, and stabilisation and storage buffers are completely independent of human plasma

A strongly changing accretion morphology during the outburst decay of the neutron star X-ray binary 4U 1608−52

It is commonly assumed that the properties and geometry of the accretion flow in transient low-mass X-ray binaries (LMXBs) significantly change when the X-ray luminosity decays below ∼10⁻² of the Eddington limit (L_(Edd)). However, there are few observational cases where the evolution of the accretion flow is tracked in a single X-ray binary over a wide dynamic range. In this work, we use NuSTAR and NICER observations obtained during the 2018 accretion outburst of the neutron star LMXB 4U 1608−52, to study changes in the reflection spectrum. We find that the broad Fe–Kα line and Compton hump, clearly seen during the peak of the outburst when the X-ray luminosity is ∼10³⁷ erg s⁻¹ (∼0.05 L_(Edd)), disappear during the decay of the outburst when the source luminosity drops to ∼4.5 × 10³⁵ erg s⁻¹ (∼0.002 L_(Edd)). We show that this non-detection of the reflection features cannot be explained by the lower signal-to-noise ratio at lower flux, but is instead caused by physical changes in the accretion flow. Simulating synthetic NuSTAR observations on a grid of inner disc radius, disc ionization, and reflection fraction, we find that the disappearance of the reflection features can be explained by either increased disc ionization (log ξ ≳ 4.1) or a much decreased reflection fraction. A changing disc truncation alone, however, cannot account for the lack of reprocessed Fe–Kα emission. The required increase in ionization parameter could occur if the inner accretion flow evaporates from a thin disc into a geometrically thicker flow, such as the commonly assumed formation of a radiatively inefficient accretion flow at lower mass accretion rates