Models and image: reconstruction in electrical impedance tomography of human brain function

Electrical Impedance Tomography (EIT) of brain function has the potential to provide a rapid portable bedside neuroimaging device. Recently, our group published the first ever EIT images of evoked activity recorded with scalp electrodes. While the raw data showed encouraging, reproducible changes of a few per cent, the images were noisy. The poor image quality was due, in part, to the use of a simplified reconstruction algorithm which modelled the head as a homogeneous sphere. The purpose of this work has been to develop new algorithms in which the model incorporates extracerebral layers and realistic geometry, and to assess their effect on image quality. An algorithm was suggested which allowed fair comparison between reconstructions assuming analytical and numerical (Finite Element Method - FEM) models of the head as a homogeneous sphere and as concentric spheres representing the brain, CSF, skull and scalp. Comparison was also made between these and numerical models of the head as a homogeneous, head-shaped volume and as a head-shaped volume with internal compartments of contrasting resistivity. The models were tested on computer simulations, on spherical and head-shaped, saline-filled tanks and on data collected during human evoked response studies. EIT also has the potential to image resistance changes which occur during neuronal depolarization in the cortex and last tens of milliseconds. Also presented in this thesis is an estimate of their magnitude made using a mathematical model, based on cable theory, of resistance changes at DC during depolarization in the cerebral cortex. Published values were used for the electrical properties and geometry of cell processes (Rail, 1975). The study was performed in order to estimate the resultant scalp signal that might be obtained and to assess the ability of EIT to produce images of neuronal depolarization

EEG–fMRI of idiopathic and secondarily generalized epilepsies

We used simultaneous EEG and functional MRI (EEG–fMRI) to study generalized spike wave activity (GSW) in idiopathic and secondary generalized epilepsy (SGE). Recent studies have demonstrated thalamic and cortical fMRI signal changes in association with GSW in idiopathic generalized epilepsy (IGE). We report on a large cohort of patients that included both IGE and SGE, and give a functional interpretation of our findings. Forty-six patients with GSW were studied with EEG–fMRI; 30 with IGE and 16 with SGE. GSW-related BOLD signal changes were seen in 25 of 36 individual patients who had GSW during EEG–fMRI. This was seen in thalamus (60%) and symmetrically in frontal cortex (92%), parietal cortex (76%), and posterior cingulate cortex/precuneus (80%). Thalamic BOLD changes were predominantly positive and cortical changes predominantly negative. Group analysis showed a negative BOLD response in the cortex in the IGE group and to a lesser extent a positive response in thalamus. Thalamic activation was consistent with its known role in GSW, and its detection in individual cases with EEG–fMRI may in part be related to the number and duration of GSW epochs recorded. The spatial distribution of the cortical fMRI response to GSW in both IGE and SGE involved areas of association cortex that are most active during conscious rest. Reduction of activity in these regions during GSW is consistent with the clinical manifestation of absence seizures

Location! Location! Location!: Reference Service in Non-Library Settings

The decline in the number of face-to-face reference transactions has implications that are of concern to librarians, as well as the faculty and students we serve. A strategy to address this is to take reference to locations that are “more convenient” for users – locations where they already work, study and gather. Three reference librarians shared their experiences with offering services in non-library settings, such as a faculty office building, a computer lab in a classroom, a student lounge, and a departmental library room. The objectives and experiences of these librarians vary, as do their specialized subject disciplines. This presentation detailed the spaces, scheduling, advertising, faculty/student relationships, evaluation/assessment strategy, and future plans unique to each locale. Handouts included a checklist of considerations for those planning mobile reference service, and a list of benefits and disadvantages from offering these services

Adaptive constraints for feature tracking

In this paper extensions to an existing tracking algorithm are described. These extensions implement adaptive tracking constraints in the form of regional upper-bound displacements and an adaptive track smoothness constraint. Together, these constraints make the tracking algorithm more flexible than the original algorithm (which used fixed tracking parameters) and provide greater confidence in the tracking results. The result of applying the new algorithm to high-resolution ECMWF reanalysis data is shown as an example of its effectiveness

A case study on practical live event sound exposure monitoring

The recently launched WHO Global Standard for Safe Listening Venues and Events aims to make listening safer and more enjoyable for audiences around the world. Some key questions remain on how to practically monitor sound exposure as well as on how patrons’ hearing may be affected after significant exposure. This paper presents a case study where various sound exposure monitoring systems and methods were trialed in an indoor music venue. The aim of the work was to develop and validate a practical, accurate and repeatable technique to track sound exposure across music venues that can be presented in real-time. Results indicate that this can be achieved with no more than four, and as few as two, sound level monitoring locations alongside fixed calibration measurements and a small number of spot measurements at the mix position during a performance

Modeling Snow Depth for Improved Simulation of Snow–Vegetation–Atmosphere Interactions

The presence of snow and its relationship to surrounding vegetation significantly impacts the surface energy balance. For accurate atmospheric model simulations, the degree to which a snowpack can cover vegetation must be realistically represented. Both vegetation height and snow depth must be reasonably known to determine the amount of masking. The Regional Atmospheric Modeling System/Land Ecosystem–Atmosphere Feedback, version two (RAMS/ LEAF-2) snow model was modified to simulate snow depth in addition to snow water equivalent and was driven offline with observed atmospheric forcing data. The model was run for five of the Boreal Ecosystem–Atmosphere Study (BOREAS) surface mesonet stations over the 1995/96 winter. The time evolution of simulated snow depth was compared with the observed snow depth. Averaged over the winter, the modeled snow depth at the four low-wind stations was within 0.09 m of the observations, and the average percent error was 27%, while the one wind-blown station was considerably worse. The average depth error at all five stations was 60.08 m. This is shown to be sufficient to reasonably account for the surface energy balance effects of vegetation protruding through the snow. 1

The tail of the Jurassic fish Leedsichthys problematicus (Osteichthyes: Actinopterygii) collected by Alfred Nicholson Leeds - an example of the importance of historical records in palaeontology

The specimen of the tail of <i>Leedsichthys problematicus</i>, now in The Natural History Museum, London, was one of the most spectacular fossil vertebrates from the Oxford Clay Formation of Peterborough, but as an isolated find it shares no bones in common with the holotype of the genus and species. However, a letter from Alfred Nicholson Leeds and related documents cast valuable new light on the excavation of the tail, indicating that it was discovered with cranial bones, gill-rakers, and two pectoral fins, thereby including elements that can potentially be compared with those of the holotype. The documents also clearly indicate that The Natural History Museum's specimen is not part of the same individual as any other numbered specimen of <i>Leedsichthys</i> as had been speculated on other occasions. The maximum size of the animal represented by The Natural History Museum's specimen was possibly around 9 metres, considerably less than previous estimates of up to 27.6 metres for <i>Leedsichthys</i>. Historical documentary evidence should therefore be rigorously checked both when studying historical specimens in science, and in preparing text for museum display labels