Association of Human Leukocyte Antigens Class II Variants with Susceptibility to Hidradenitis Suppurativa in a Caucasian Spanish Population

Hidradenitis suppurativa (HS) is a chronic inflammatory cutaneous disease of the hair follicle typically presenting recurrent, painful, and inflamed lesions on the inverse areas of the body. Although its pathogenesis remains unknown, the immune system appears to play a potential role. To date, two previous studies have not found any association between the Human Leukocyte Antigen system (HLA) and HS. In this study we analyzed the HLA-A, -B, -C; and DRB1, -DQA1, and ?DQB1 allele distribution in 106 HS patients and 262 healthy controls from a Caucasian population in Cantabria (northern Spain). HLA-A*29 and B*50 were significantly more common in HS patients and A*30 and B*37 in controls, but these associations disappeared after statistical correction. DRB1*07, DQA1*02, and DQB1*02 were significantly more common in controls (p 0.026, p 0.0012, and p 0.0005, respectively) and the HLA allele DQB1*03:01 was significantly more common in HS patients (p 0.00007) after the Bonferroni correction. The DRB1*07~DQA1*02~DQB1*02 haplotype was significantly more common in controls (p < 0.0005). This is the first study showing an association between HLA-class II and HS. Our results suggest that HLA-II alleles (DRB1*07, DQA1*02, DQB1*02, and DQB1*03:01) and the DRB1*07~DQA1*02~DQB1*02 haplotype could influence resistance or susceptibility to HS

Effects of the linear polarization of polariton condensates in their propagation in codirectional couplers

We report on the linear polarization of polariton condensates in a codirectional coupler that allows evanescent coupling between adjacent waveguides. During the condensate's formation, polaritons usually acquire a randomly oriented polarization, however, our results reveal a preferential orientation of the linear polarization along the waveguide propagation path. Furthermore, we observe polarization-dependent intensity oscillations in the output terminal of the coupler, and we identify the mode beating between the linear-polarized eigenmodes as the origin of these oscillations. Our findings provide an insight into the control of the polarization of polariton condensates, paving the way for the development of spin-based polaritonic architectures where condensates propagate over macroscopic distancesThis work has been partly supported by the Spanish MINECO Grant Nos. MAT2017-83722-R and PID2020-113445GB-I00. A.Y. and I.A.S. were financially supported by the Ministry of Science and Higher Education of the Russian Federation through Megagrant Number 14.Y26.31.0015 and Goszadanie No. 2019-1246. I.A.S. acknowledges also the support from theIcelandic research fund, Grant No. 163082-051. The Würzburgand Jena group acknowledges financial support within the DFGProject Nos. PE 523/18-1 and KL3124/2-1. The Würzburggroup acknowledges financial support by the German ResearchFoundation (DFG) under Germany’s Excellence Strategy−EXC2147 “ct.qmat” (Project No. 390858490) and is grateful forsupport by the state of Bavari

Follow-up with Telemedicine in Early Discharge for COPD Exacerbations: Randomized Clinical Trial (TELEMEDCOPD-Trial)

The results reported by different studies on telemonitoring in patients with chronic obstructive pulmonary disease (COPD) have been contradictory, without showing clear benefits to date. The objective of this study was to ascertain whether an early discharge and home hospitalization telehealth program for patients with COPD exacerbation is as effective as and more efficient than a traditional early discharge and home hospitalization program. A prospective experimental non-inferiority study, randomized into two groups (telemedicine/control) was conducted. The telemedicine group underwent monitoring and was required to transmit data on vital constants and ECGs twice per day, with a subsequent telephone call and 2 home visits by healthcare staff (intermediate and at discharge). The control group received daily visits. The main variable was time until first exacerbation. The secondary variables were: number of exacerbations; use of healthcare resources; satisfaction; quality of life; anxiety-depression; and therapeutic adherence, measured at one and 6 months of hospital discharge. A total of 116 patients were randomized (58 to each group) without significant differences in baseline characteristics or time until first exacerbation, i.e. median 48 days (pp. 25-75:23-120) in the control group, and 47 days (pp. 25-75:19-102) in the intervention group; p = 0.52). A significant decrease in the number of visits was observed in the intervention versus the control group, 3.8 ± 1 vs 5.1 ± 2(p = 0.001), without significant differences in the number of exacerbations. In conclusion follow-up via a telemedicine program in early discharge after hospitalization is as effective as conventional home follow up, being the cost of either strategy not significantly different.This study was awarded a Health Research Fund (Fondo de Investigaciones Sanitarias/FIS) grant, dossier No. PI12/01161 of the Carlos III Institute of Health and the Ministry of Sciences, Innovation and Universities.S

Pachyrhizus ahipa: reassessment of ancient crop as alternative starch source

La ahipa (Pachyrhizus ahipa) es una planta Leguminosa cultivada antiguamente en la región andina, caracterizada por su resistencia al ataque de diversas plagas. Su raíz tuberosa acumula almidón como compuesto de reserva. El objetivo de este trabajo fue evaluar el comportamiento del cultivo de ahipa en la provincia de Misiones, caracterizar la composición química de las raíces obtenidas, analizar su conservación, implementar un proceso para obtener su almidón y evaluar las propiedades funcionales del mismo. P. ahipa se adaptó satisfactoriamente a las condiciones agroecológicas de Misiones, permitiendo obtener rendimientos máximos de 20.839 kg ha-1. Una vez en el CIDCA, las raíces se acondicionaron para su almacenamiento a 4, 10 ó 25ºC. Inicialmente, se cuantificó humedad, cenizas totales, materia grasa, fibra cruda, proteínas totales, compuestos libres de nitrógeno, concentración de sólidos solubles (ºBrix) y producción de CO2. Asimismo, durante el almacenamiento se determinó el color en el corte transversal de las raíces (usando un colorímetro Minolta CR400) y la textura (análisis del perfil de textura, TPA). Los resultados obtenidos permiten señalar que el tenor de proteínas (6,5%) resultaría medio, dado el elevado contenido de humedad de las muestras (82%). Sin embargo dicho contenido resultó superior al de otras raíces, como batata y mandioca. La conservación a bajas temperaturas produjo considerable daño por frío y ocasionó proliferación de microorganismos, en tanto que el almacenamiento a 25ºC no indujo cambios significativos en el color o la textura de las raíces de ahipa. El proceso de extracción de almidón comenzó con el lavado, pelado y procesado de las raíces. La pasta rallada se colocó en agua y se almacenó a 4°C durante 24h. La mezcla se filtró y se obtuvo el almidón en suspensión acuosa que se decantó a 4°C. El material insoluble sedimentado se secó a 40°C y se sometió a molienda. El rendimiento de la extracción de almidón de raíces de ahipa fue de 56,54 g/100 g de materia seca. Con el fin de proponer usos alimentarios para este producto, se evaluó la gelatinización y la retrogradación en condiciones de refrigeración de sus pastas mediante DSC, TPA y estudio del grado de sinéresis. Se halló que el almidón de ahipa gelatinizó a 67,18°C y sus pastas no retrogradaron en los tiempos ensayados, ya que la dureza de los geles no varió significativamente y el grado de sinéresis resultó muy bajo. Las propiedades funcionales evaluadas indican que el almidón de ahipa sería un espesante adecuado para la formulación de alimentos refrigerados.Ahipa (Pachyrhizus ahipa) is a leguminous plant cultivated formerly in the Andean region, characterized by its resistance to the attack of diverse pests. Ahipa tuberous root accumulates starch as reserve compound. The objective of this work was to evaluate ahipa crop management in Misiones (Argentina), to characterize the chemical composition of the obtained roots, to analyze its conservation, to implement a process to obtain ahipa starch and to evaluate its functional properties. P. ahipa successfully adapted to the agroecological conditions of Misiones, allowing maximum yield of 20,839 kg ha-1. Once in the CIDCA, roots were conditioned for storage at 4, 10 or 25 º C. Initially, moisture content, total ash, fat, crude fiber, total protein, nitrogen-free compounds, total soluble solids (º Brix) and CO2 production were quantified. During storage, color changes in the cut section of the roots (measured using a Minolta colorimeter CR400) and texture (texture profile analysis, TPA) were evaluated. Results indicate that the protein content (6.5%) would be intermediate, since samples showed relatively high moisture content (82%). However, protein levels were higher than that of other roots, like sweet potatoe and cassava. Conservation at low temperatures resulted in considerable injury and caused proliferation of microorganisms, while storage at 25 ° C did not cause significant changes in color or texture of the roots. The process of starch extraction began with the washing, peeling and processing of the ahipa roots. The paste of the grated ahipa was placed in water and stored at 4°C during 24hs. The mixture was filtered and the starch presented in the aqueous suspension was poured off at 4°C. The settled insoluble material was dried at 40°C and it was triturating. The yield of the extracted starch of the ahipa roots was 56.54 g/100 g of dry matter. In order to suggest food uses for this product, the starch pastes gelatinization and retrogradation under refrigeration conditions were evaluated by DSC, TPA and syneresis degree. Ahipa starch gelatinized at 67.18°C and its pastes did not retrograded during the assayed times, since the gels hardness did not significantly vary and the syneresis degree was too low. The evaluated starch functional properties indicate that it is an adequate thickener for refrigerated foods.Centro de Investigación y Desarrollo en Criotecnología de Alimento

Complement-Binding Donor-Specific Anti-HLA Antibodies and Risk of Primary Graft Failure in Hematopoietic Stem Cell Transplantation

AbstractDetection of donor-specific anti-HLA antibodies (DSA) has been associated with graft rejection in all forms of transplantation. The mechanism by which DSA increase the risk of graft failure remains unclear. We hypothesized that complement-binding DSA are associated with engraftment failure in hematopoietic stem cell transplantation (HSCT) and analyzed 122 haploidentical transplant recipients tested prospectively for DSA. Retrospective analysis to detect C1q binding DSA (C1q+DSA) was performed on 22 allosensitized recipients. Twenty-two of 122 patients (18%) had DSA, 19 of which were women (86%). Seven patients with DSA (32%) rejected the graft. Median DSA level at transplant for patients who failed to engraft was 10,055 mean fluorescence intensity (MFI) versus 2065 MFI for those who engrafted (P = .007). Nine patients with DSA were C1q positive in the initial samples with median DSA levels of 15,279 MFI (range, 1554 to 28,615), compared with 7 C1q-negative patients with median DSA levels of 2471 MFI (range, 665 to 12,254) (P = .016). Of 9 patients who were C1q positive in the initial samples, 5 patients remained C1q positive at time of transplant (all with high DSA levels [median, 15,279; range, 6487 to 22,944]) and experienced engraftment failure, whereas 4 patients became C1q negative pretransplant and all engrafted the donor cells (P = .008). In conclusion, patients with high DSA levels (>5000 MFI) and complement-binding DSA antibodies (C1q positive) appear to be at much higher risk of primary graft failure. The presence of C1q+DSA should be assessed in allosensitized patients before HSCT. Reduction of C1q+DSA levels might prevent engraftment failure in HSCT

Segundo Congreso Salesiano de Ciencia, Tecnología e Innovación para la Sociedad

La segunda edición del Congreso Salesiano de Ciencia, Tecnología e Innovación para la Sociedad, CITIS, realizado el 2 y 3 de diciembre de 2015 y organizado por la Universidad Politécnica Salesiana (sede Guayaquil), ofreció un espacio idóneo para la presentación, difusión e intercambio de importantes investigaciones (nacionales e internacionales) a los docentes investigadores y a la comunidad universitaria en general. Los trabajos recogidos en estas Memorias Académicas pertenecen a diferentes líneas de investigación del área de la Ingeniería: Telecomunicaciones, Automatización y Control, Procesos Industriales, Sistemas Eléctricos de Potencia, Telemática e Informática Aplicada, áreas de interés en esta segunda edición del CITIS. Cabe destacar que se evidencia la preocupación por la dimensión humana y social mediante el desarrollo responsable de la ciencia y la tecnología. La realización de este Congreso ha puesto en evidencia la importancia y pertinencia de la actividad investigativa que se genera en las universidades (en proyectos desarrollados por los docentes investigadores e, incluso, por los estudiantes de grado y posgrado), así como los altos niveles de compromiso académico y social