Mars spacecraft power system development Interim report

Modified Mariner power system design for Mars mission

Mars Spacecraft Power System Development Final Report

Development of optimum Mariner spacecraft power system for application to future flyby and orbiter mission

Role of Nutrition in Alcoholic Liver Disease: Summary of the Symposium at the ESBRA 2017 Congress.

The symposium, "Role of Nutrition in Alcoholic Liver Disease", was held at the European Society for Biomedical Research on Alcoholism Congress on 9 October 2017 in Crete, Greece. The goal of the symposium was to highlight recent advances and developments in the field of alcohol and nutrition. The symposium was focused on experimental and clinical aspects in relation to the role of different types of dietary nutrients and malnutrition in the pathogenesis of alcoholic liver disease (ALD). The following is a summary of key research presented at this session. The speakers discussed the role of dietary fats and carbohydrates in the development and progression of alcohol-induced multi-organ pathology in animal models of ALD, analyzed novel nutrition-related therapeutics (specifically, betaine and zinc) in the treatment of ALD, and addressed clinical relevance of malnutrition and nutrition support in ALD. This summary of the symposium will benefit junior and senior faculty currently investigating alcohol-induced organ pathology as well as undergraduate, graduate, and post-graduate students and fellows

Радіометричні вимірювання електромагнітних полів слабко концентрованих розчинів солі і цукру

In the article results of research extraordinarily of low power radiations of the poorly concentrated solutions of salt, sugar, and also other physical and biological objectives at mm-range of wavelengthВ статье приведены результаты исследования чрезвычайно слабых излучений слабо концентрированных растворов соли и сахара, а также других физических и биологических объектов в мм-диапазоне волнВ статті наведені результати дослідження надзвичайно слабких випромінювань слабо концентрованих розчинів солі і цукру, а також інших фізичних і біологічних об′єктів в мм-діапазоні хвил

Trade-off between cost and accuracy in large-scale surface water dynamic modeling

Recent efforts have led to the development of the local inertia formulation (INER) for anaccurate but still cost-efficient representation of surface water dynamics, compared to the widely used kinematic wave equation (KINE). In this study, both formulations are evaluated over the Amazon basin in terms of computational costs and accuracy in simulating streamflows and water levels through synthetic experiments and comparisons against ground-based observations. Varying time steps are considered as part of the evaluation and INER at 60-second time step is adopted as the reference for synthetic experiments. Five hybrid (HYBR) realizations are performed based on maps representing the spatial distribution of the two formulations that physically represent river reach flow dynamics within the domain. Maps have fractions of KINE varying from 35.6% to 82.8%. KINE runs show clear deterioration along the Amazon river andmain tributaries, with maximum RMSE values for streamflow and water level reaching7827m(exp 3).s(exp -1) and 1379 cm near the basins outlet. However, KINE 20 is at least 25%more efficient than INER with low model sensitivity to longer time steps. A significant improvement is achieved with HYBR, resulting in maximum RMSE values of 3.9-292 m(exp 3).s(exp -1) for streamflows and 1.1-28.5 cm for water levels, and cost reduction of 6-16%, depending on the map used. Optimal results using HYBR are obtained when the local inertia formulation is used in about one third of the Amazon basin, reducing computational costs in simulations while preserving accuracy. However, that threshold may vary when applied to different regions, according to their hydrodynamics and geomorphological characteristics

Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury

It is likely that the majority of proteins will undergo post-translational modification, be it enzymatic or non-enzymatic. These modified protein(s) regulate activity, localization and interaction with other cellular molecules thereby maintaining cellular hemostasis. Alcohol exposure significantly alters several of these post-translational modifications leading to impairments of many essential physiological processes. Here, we present new insights into novel modifications following ethanol exposure and their role in the initiation and progression of liver injury. This critical review condenses the proceedings of a symposium at the European Society for the Biomedical Research on Alcoholism Meeting held September 12-15, 2015, in Valencia, Spain

Alcohol, microbiome, life style influence alcohol and non-alcoholic organ damage

This paper is based upon the "8th Charles Lieber's Satellite Symposium" organized by Manuela G. Neuman at the Research Society on Alcoholism Annual Meeting, on June 25, 2016 at New Orleans, Louisiana, USA. The integrative symposium investigated different aspects of alcohol-induced liver disease (ALD) as well as non alcohol -induced liver disease (NAFLD) and possible repair. We revealed the basic aspects of alcohol metabolism that may be responsible for the development of liver disease as well as the factors that determine the amount, frequency and which type of alcohol misuse leads to liver and gastrointestinal diseases. We aimed to (1) describe the immuno-pathology of ALD, (2) examine the role of genetics in the development of alcoholic hepatitis (ASH) and NAFLD, (3) propose diagnostic markers of ASH and non-alcoholic steatohepatitis (NASH), (4) examine age and ethnic differences as well as analyze the validity of some models, (5) develop common research tools and biomarkers to study alcohol-induced effects, 6) examine the role of alcohol in oral health and colon and gastrointestinal cancer and (7) focus on factors that aggravate the severity of organ-damage. The present review includes pre-clinical, translational and clinical research that characterizes ALD and NAFLD. Strong clinical and experimental evidence lead to recognition of the key toxic role of alcohol in the pathogenesis of ALD with simple fatty infiltrations and chronic alcoholic hepatitis with hepatic fibrosis or cirrhosis. These latter stages may also be associated with a number of cellular and histological changes, including the presence of Mallory's hyaline, megamitochondria, or perivenular.and perisinusoidal fibrosis. Genetic polymorphisms of ethanol metabolizing enzymes and cytochrome p450 (CYP) 2E1 activation may change the severity of ASH and NASH. Other risk factors such as its co-morbidities with chronic viral hepatitis in the presence or absence of human deficiency virus were discussed. Dysregulation of metabolism, as a result of ethanol exposure, in the intestine leads to colon carcinogenesis. The hepatotoxic effects of ethanol undermine the contribution of malnutrition to the liver injury. Dietary interventions such as micro and macronutrients, as well as changes to the microbiota have been suggested. The clinical aspects of NASH, as part of the metabolic syndrome in the aging population, have been presented. The symposium addressed mechanisms and biomarkers of alcohol induced damage to different organs, as well as the role of the microbiome in this dialog. The microbiota regulates and acts as a key element in harmonizing immune responses at intestinal mucosal surfaces. It is known that microbiota is an inducer of proinflammatory T helper 17 cells and regulatory T cells in the intestine. The signals at the sites of inflammation mediate recruitment and differentiation in order to remove inflammatory inducers and promote tissue homeostasis restoration. The change in the intestinal microbiota also influences the change in obesity and regresses the liver steatosis. Evidence on the positive role of moderate alcohol consumption on heart and metabolic diseases as well on reducing steatosis have been looked up. Moreover nutrition as a therapeutic intervention in alcoholic liver disease has been discussed. In addition to the original data, we searched the literature (2008-2016) for the latest publication on the described subjects. In order to obtain the updated data we used the usual engines (Pub Med and Google Scholar). The intention of the eighth symposia was to advance the international profile of the biological research on alcoholism. We also wish to further our mission of leading the forum to progress the science and practice of translational research in alcoholism. (C) 2017 Elsevier Inc. All rights reserved.Peer reviewe