19,186 research outputs found
Induced pluripotent stem cells, a giant leap for mankind therapeutic applications
Induced pluripotent stem cells (iPSC) technology has propelled the field of stem
cells biology, providing new cells to explore the molecular mechanisms of
pluripotency, cancer biology and aging. A major advantage of human iPSC,
compared to the pluripotent embryonic stem cells, is that they can be generated
from virtually any embryonic or adult somatic cell type without destruction of
human blastocysts. In addition, iPSC can be generated from somatic cells
harvested from normal individuals or patients, and used as a cellular tool to
unravel mechanisms of human development and to model diseases in a manner
not possible before. Besides these fundamental aspects of human biology and
physiology that are revealed using iPSC or iPSC-derived cells, these cells hold an
immense potential for cell-based therapies, and for the discovery of new or
personalized pharmacological treatments for many disorders. Here, we review
some of the current challenges and concerns about iPSC technology. We
introduce the potential held by iPSC for research and development of novel
health-related applications. We briefly present the efforts made by the scientific
and clinical communities to create the necessary guidelines and regulations to
achieve the highest quality standards in the procedures for iPSC generation,
characterization and long-term preservation. Finally, we present some of the
audacious and pioneer clinical trials in progress with iPSC-derived cells.info:eu-repo/semantics/publishedVersio
Massive MIMO Full-Duplex Relaying with Optimal Power Allocation for Independent Multipairs
With the help of an in-band full-duplex relay station, it is possible to
simultaneously transmit and receive signals from multiple users. The
performance of such system can be greatly increased when the relay station is
equipped with a large number of antennas on both transmitter and receiver
sides. In this paper, we exploit the use of massive arrays to effectively
suppress the loopback interference (LI) of a decode-and-forward relay (DF) and
evaluate the performance of the end-to-end (e2e) transmission. This paper
assumes imperfect channel state information is available at the relay and
designs a minimum mean-square error (MMSE) filter to mitigate the interference.
Subsequently, we adopt zero-forcing (ZF) filters for both detection and
beamforming. The performance of such system is evaluated in terms of bit error
rate (BER) at both relay and destinations, and an optimal choice for the
transmission power at the relay is shown. We then propose a complexity
efficient optimal power allocation (OPA) algorithm that, using the channel
statistics, computes the minimum power that satisfies the rate constraints of
each pair. The results obtained via simulation show that when both MMSE
filtering and OPA method are used, better values for the energy efficiency are
attained.Comment: Accepted to the 16th IEEE International Workshop on Signal Processing
Advances in Wireless Communications - SPAWC, Stockholm, Sweden 201
A Statistical Model to Explain the Mendel--Fisher Controversy
In 1866 Gregor Mendel published a seminal paper containing the foundations of
modern genetics. In 1936 Ronald Fisher published a statistical analysis of
Mendel's data concluding that "the data of most, if not all, of the experiments
have been falsified so as to agree closely with Mendel's expectations." The
accusation gave rise to a controversy which has reached the present time. There
are reasonable grounds to assume that a certain unconscious bias was
systematically introduced in Mendel's experimentation. Based on this
assumption, a probability model that fits Mendel's data and does not offend
Fisher's analysis is given. This reconciliation model may well be the end of
the Mendel--Fisher controversy.Comment: Published in at http://dx.doi.org/10.1214/10-STS342 the Statistical
Science (http://www.imstat.org/sts/) by the Institute of Mathematical
Statistics (http://www.imstat.org
A multiparameter family of irreducible representations of the quantum plane and of the quantum Weyl algebra
We construct a family of irreducible representations of the quantum plane and
of the quantum Weyl algebra over an arbitrary field, assuming the deformation
parameter is not a root of unity. We determine when two representations in this
family are isomorphic, and when they are weight representations, in the sense
of Bavula.Comment: 12 pages, Section 2 has been reorganized, new material added in a new
Section
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Capacity and tendency: A neuroscientific framework for the study of emotion regulation.
It is widely accepted that the ability to effectively regulate one's emotions is a cornerstone of physical and mental health. As such, it should come as no surprise that the number of neuroimaging studies focused on emotion regulation and associated processes has increased exponentially in the past decade. To date, neuroimaging research on this topic has examined two distinct but complementary features of emotion regulation - the capacity to effectively utilize a strategy to regulate emotion and to a lesser extent, the tendency to choose to regulate. However, theoretical accounts of emotion regulation have only recently begun to distinguish capacity from tendency. In the present review, we provide a novel framework for conceptualizing these two intertwined, yet distinct, facets of emotion regulation. First we characterize brain regions that support emotion generation and are thus targeted by emotion regulation. Next, we synthesize findings from the dozens of neuroimaging studies that have examined emotion regulation capacity, focusing in particular on the most commonly studied emotion regulation strategy - reappraisal. Finally, we discuss emerging neuroimaging research examining state and trait regulatory tendencies. We conclude by integrating findings from neuroimaging research on emotion regulation capacity and tendency and suggest ways that this integrated model can inform basic and translational neuroscientific research on emotion regulation
Delay-Optimal Relay Selection in Device-to-Device Communications for Smart Grid
The smart grid communication network adopts a hierarchical structure which consists of three kinds of networks which are Home Area Networks (HANs), Neighborhood Area Networks (NANs), and Wide Area Networks (WANs). The smart grid NANs comprise of the communication infrastructure used to manage the electricity distribution to the end users. Cellular technology with LTE-based standards is a widely-used and forward-looking technology hence becomes a promising technology that can meet the requirements of different applications in NANs. However, the LTE has a limitation to cope with the data traffic characteristics of smart grid applications, thus require for enhancements. Device-to-Device (D2D) communications enable direct data transmissions between devices by exploiting the cellular resources, which could guarantee the improvement of LTE performances. Delay is one of the important communication requirements for the real-time smart grid applications. In this paper, the application of D2D communications for the smart grid NANs is investigated to improve the average end-to-end delay of the system. A relay selection algorithm that considers both the queue state and the channel state of nodes is proposed. The optimization problem is formulated as a constrained Markov decision process (CMDP) and a linear programming method is used to find the optimal policy for the CMDP problem. Simulation results are presented to prove the effectiveness of the proposed scheme
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