Comparative assessment of spatial variability and trends of flows and sediments under the impact of climate change in the upper Indus basin

Extensive research of the variability of flows under the impact of climate change has been conducted for the Upper Indus Basin (UIB). However, limited literature is available on the spatial distribution and trends of suspended sediment concentrations (SSC) in the sub-basins of UIB. This study covers the comparative assessment of flows and SSC trends measured at 13 stations in the UIB along with the variability of precipitation and temperatures possibly due to climate change for the past three decades. In the course of this period, the country’s largest reservoir, Tarbela, on the Indus River was depleted rapidly due to heavy sediment influx from the UIB. Sediment management of existing storage and future planned hydraulic structures (to tap 30,000 MW in the region) depends on the correct assessment of SSC, their variation patterns, and trends. In this study, the SSC trends are determined along with trends of discharges, precipitation, and temperatures using the non-parametric Mann–Kendall test and Sen’s slope estimator. The results reveal that the annual flows and SSC are in a balanced state for the Indus River at Besham Qila, whereas the SSC are significantly reduced ranging from 18.56%–28.20% per decade in the rivers of Gilgit at Alam Bridge, Indus at Kachura, and Brandu at Daggar. The SSC significantly increase ranging from 20.08%–40.72% per decade in the winter together with a significant increase of average air temperature. During summers, the SSC are decreased significantly ranging from 18.63%–27.79% per decade along with flows in the Hindukush and Western–Karakorum regions, which is partly due to the Karakorum climate anomaly, and in rainfall-dominated basins due to rainfall reduction. In Himalayan regions, the SSC are generally increased slightly during summers. These findings will be helpful for understanding the sediment trends associated with flow, precipitation, and temperature variations, and may be used for the operational management of current reservoirs and the design of several hydroelectric power plants that are planned for construction in the UIB

Fluctuating rainfall as one of the important cause for desertification in Iraq

Desertification is regarded as one of the most problems over the entire world. There are many reasons lead to this problem. Climatic factors such (rainfall, temperature and evaporation) are some of them. Annual rainfall amount is one of the most important parameters that lead to desertification for this reason it chosen to achieve this research. In this paper rainfall data with the help of Geographic Information System (GIS) to produce maps of Iraqi surface climate. In order to achieve this goal, the available data from a number of climate monitoring stations located on the surface of the country has been were adopted. The annual mean of rainfall for the period from 1990 to 2010 has been used. The Iraqi shape file map was used to overlay the results. The output of the research are presented in GIS maps that demonstrating the variation of rainfall over the study period for the monitoring climate stations

Symmetric and Asymmetric Multilevel Inverter Topologies With Reduced Device Count

In this work, two new topologies of single-phase hybrid multilevel inverters for symmetrical and asymmetrical configurations are presented for use in drives and control of electrical machines and the connection of renewable energy sources. The proposed topology uses 2 dc sources, 12 switches, 1 flying capacitor, and 3 diodes to generate boosted 13-levels and 17-levels for symmetric and asymmetric configuration, respectively. Self-voltage balancing of its capacitor voltage regardless of load type, load dynamics, or modulation index is a key advantage of the suggested design. The higher performance of proposed topologies in terms of the total number of switches, TSV, THD, switch stress, and dc sources are demonstrated by comparing those with recently published topologies. In addition, a widely employed nearest level control modulation approach is used to provide output voltage levels with low THD. Finally, experiments were undertaken to validate the performance of the suggested topology. 2013 IEEE.This work was supported in part by Qatar University Research Grant from Qatar University, Doha, Qatar, under Grant QUCP-CENG-2020-2 and Grant QUCP-CENG-2022-571; and in part by the Qatar National Library, Doha.Scopu

Determining the Contribution of Different Structural Layers of Asphalt Pavement System to Rutting Using Transverse Profile Analysis

Abstract Rutting is one of the major distresses which cause hydroplaning and structural failures in a flexible pavement. The extent of damage depends upon the load induced and the strength of each pavement layer. Rutting can occur due to the failure of the subgrade, the base or at the wearing surface/ hot mixasphalt (HMA) layer(s).In order to take remedial measures, it is imperative to be cognizant of the contribution of each layer to ascertain the cause of underlying phenomena of rutting. This research study demonstrates the analysis of the pavement transverse surface profile that could be used to identify the layer responsible for the permanent deformation. Transverse surface profiling techniqueis easier, non-destructive, and economicalas compared to traditional methods of coring and trenching to examine underlying layers. A 300 meter section on National Highway (N-5) was selected exhibiting severe rutting to perform transverse profile analysis. Results of this study suggest that rutting at the selected site is mainly due to the shear failure of HMA layer. These results were also validated by field trenching on the test section. The study concluded that HMA layer should be removed and replaced with appropriately designed high performance mix specifications

Design of Compact Dual-band Fractal Monopole Antenna with Virtually Extended Ground Plane

Achieving a particular response to serve multiple wireless applications is regarded as the primary demand in our modern age because of the considerable development of the communication devices. In this paper, a compact monopole antenna with reduced ground plane has been suggested to meet the requirements of the dual-band WLAN applications. The antenna miniaturization has been carried out in employing two techniques. Initially, the fractal geometry has been applied to the antenna radiating element. Two-sided Koch fractal curves up to the third iteration have been used to increase the path of electrical current on the surface of the radiating element which is in the form of a square with dimensions. To gain more miniaturization, the antenna ground plane has been further reduced by using different lengths of two open-ended parallel stubs to form a virtually extended ground plane. This supportive technique has been adopted as a tuning means to control the path of the electrical currents exciting the resulting resonances. The proposed antenna and has been printed on an FR-4 substrate with a thickness of 1.6 mm and 4.4 relative dielectric constant and is fed by 50-ohm microstrip feed line. The resulting antenna dimensions are of about 19.1 mm × 19.1 mm. A parametric study has been carried out, and the results reveal that the proposed antenna offers a dual-band performance with a considerable ratio of resonant frequencies covering the existing 2.4/5.2/5.8 GHz WLAN applications, besides many other communication services

Structures of the CCR5 N Terminus and of a Tyrosine-Sulfated Antibody with HIV-1 gp120 and CD4

The CCR5 co-receptor binds to the HIV-l gp120 envelope glycoprotein and facilitates HIV-l entry into cells. Its N terminus is tyrosine-sulfated, as are many antibodies that react with the co-receptor binding site on gp120. We applied nuclear magnetic resonance and crystallographic techniques to analyze the structure of the CCR5 N terminus and that of the tyrosine-sulfated antibody 412d in complex with gp120 and CD4. The conformations of tyrosine-sulfated regions of CCR5 (α-helix) and 412d (extendedloop) are surprisingly different. Nonetheless, a critical sulfotyrosine on CCR5 and on 412d induces similar structural rearrangements in gp120. These results now provide a framework for understanding HIV-l interactions with the CCR5 N terminus during viral entry and define a conserved site on gp120, whose recognition of sulfotyrosine engenders posttranslational mimicry by the immune system

Structures of the CCR5 N Terminus and of a Tyrosine-Sulfated Antibody with HIV-1 gp120 and CD4

The CCR5 co-receptor binds to the HIV-l gp120 envelope glycoprotein and facilitates HIV-l entry into cells. Its N terminus is tyrosine-sulfated, as are many antibodies that react with the co-receptor binding site on gp120. We applied nuclear magnetic resonance and crystallographic techniques to analyze the structure of the CCR5 N terminus and that of the tyrosine-sulfated antibody 412d in complex with gp120 and CD4. The conformations of tyrosine-sulfated regions of CCR5 (α-helix) and 412d (extendedloop) are surprisingly different. Nonetheless, a critical sulfotyrosine on CCR5 and on 412d induces similar structural rearrangements in gp120. These results now provide a framework for understanding HIV-l interactions with the CCR5 N terminus during viral entry and define a conserved site on gp120, whose recognition of sulfotyrosine engenders posttranslational mimicry by the immune system

Approximation for Cooperative Interactions of a Spatially-Detailed Cardiac Sarcomere Model

We developed a novel ordinary differential equation (ODE) model, which produced results that correlated well with the Monte Carlo (MC) simulation when applied to a spatially-detailed model of the cardiac sarcomere. Configuration of the novel ODE model was based on the Ising model of myofilaments, with the “co-operative activation” effect introduced to incorporate nearest-neighbor interactions. First, a set of parameters was estimated using arbitrary Ca transient data to reproduce the combinational probability for the states of three consecutive regulatory units, using single unit probabilities for central and neighboring units in the MC simulation. The parameter set thus obtained enabled the calculation of the state transition of each unit using the ODE model with reference to the neighboring states. The present ODE model not only provided good agreement with the MC simulation results but was also capable of reproducing a wide range of experimental results under both steady-state and dynamic conditions including shortening twitch. The simulation results suggested that the nearest-neighbor interaction is a reasonable approximation of the cooperativity based on end-to-end interactions. Utilizing the modified ODE model resulted in a reduction in computational costs but maintained spatial integrity and co-operative effects, making it a powerful tool in cardiac modeling

Need for recovery amongst emergency physicians in the UK and Ireland: A cross-sectional survey

OBJECTIVES: To determine the need for recovery (NFR) among emergency physicians and to identify demographic and occupational characteristics associated with higher NFR scores. DESIGN: Cross-sectional electronic survey. SETTING: Emergency departments (EDs) (n=112) in the UK and Ireland. PARTICIPANTS: Emergency physicians, defined as any registered physician working principally within the ED, responding between June and July 2019. MAIN OUTCOME MEASURE: NFR Scale, an 11-item self-administered questionnaire that assesses how work demands affect intershift recovery. RESULTS: The median NFR Score for all 4247 eligible, consented participants with a valid NFR Score was 70.0 (95% CI: 65.5 to 74.5), with an IQR of 45.5-90.0. A linear regression model indicated statistically significant associations between gender, health conditions, type of ED, clinical grade, access to annual and study leave, and time spent working out-of-hours. Groups including male physicians, consultants, general practitioners (GPs) within the ED, those working in paediatric EDs and those with no long-term health condition or disability had a lower NFR Score. After adjusting for these characteristics, the NFR Score increased by 3.7 (95% CI: 0.3 to 7.1) and 6.43 (95% CI: 2.0 to 10.8) for those with difficulty accessing annual and study leave, respectively. Increased percentage of out-of-hours work increased NFR Score almost linearly: 26%-50% out-of-hours work=5.7 (95% CI: 3.1 to 8.4); 51%-75% out-of-hours work=10.3 (95% CI: 7.6 to 13.0); 76%-100% out-of-hours work=14.5 (95% CI: 11.0 to 17.9). CONCLUSION: Higher NFR scores were observed among emergency physicians than reported in any other profession or population to date. While out-of-hours working is unavoidable, the linear relationship observed suggests that any reduction may result in NFR improvement. Evidence-based strategies to improve well-being such as proportional out-of-hours working and improved access to annual and study leave should be carefully considered and implemented where feasible