Interview with Harold A. Dunkelberger, July 29, 1999

The first of two interviews, Harold A. Dunkelberger, a student and professor at Gettysburg College, was interviewed on July 29, 1999 by Michael J. Birkner & David Hedrick. He graduated with the class of 1936, and discusses his experience as a student of English at Gettysburg and his time at the Gettysburg Seminary. Length of Interview: 87 minutes Collection Note: This oral history was selected from the Oral History Collection maintained by Special Collections & College Archives. Transcripts are available for browsing in the Special Collections Reading Room, 4th floor, Musselman Library. GettDigital contains the complete listing of oral histories done from 1978 to the present. To view this list and to access selected digital versions please visit -- http://gettysburg.cdmhost.com/cdm/landingpage/collection/p16274coll

Implicit Self-Esteem in Borderline Personality and Depersonalization Disorder

Self-perception is disrupted in people with borderline personality disorder (BPD) and depersonalization disorder (DPD), fluctuating with sudden shifts in affect in BPD and experienced as detached in DPD. Measures of implicit self-esteem (ISE), free from conscious control and presentation biases, may highlight how such disruptions of self-concept differentially affect these two populations on an unconscious level. We examined ISE using the Implicit Association Test, along with measures of emotion, behavior, and temperament, in BPD (n = 18), DPD (n = 18), and healthy control (n = 35) participants. DPD participants had significantly higher ISE and were more harm avoidant than BPD and control participants, while BPD participants had more “frontal” behaviors and impulsivity and less self-directedness and cooperativeness than DPD and control participants. Thus, while BPD and DPD commonly overlap in terms of dissociative symptoms and emotional irregularities, differences in self-esteem, behavior, and temperament can help identify where they diverge in terms of their cognition, behavior, and ultimately underlying neurobiology

Home slaughtering and processing of beef (1993)

This article cites the proper method and precautions for slaughtering beef cattle at home

Schlafen, a New Family of Growth Regulatory Genes that Affect Thymocyte Development

AbstractThe Schlafen (Slfn) family of genes are differentially regulated during thymocyte maturation and are preferentially expressed in the lymphoid tissues. Ectopic expression of the prototype member Slfn1 early in the T lineage profoundly alters cell growth and development. In these mice, the DP thymocytes fail to complete maturation, and, depending on the transgene dosage, the number of thymocytes is reduced to 1%–30% of normal. Furthermore, expression of the Schlafen family members in fibroblasts and thymoma cells either retards or ablates cell growth. The conceptual protein sequences deduced for each of the family members have no similarity to characterized proteins and must therefore participate in a heretofore unknown regulatory mechanism guiding both cell growth and T cell development

One Direction real person fiction on Wattpad.com: A textual analysis of sexual consent

This study focuses on the dominant scripts for sexual consent represented in popular fictional stories of celebrities written by their female fans. A textual analysis was performed on a subset of the most read real person fiction (RPF) stories—a type of fanfiction— about the popular boy band One Direction. Stories were publicly available from an online fiction-writing platform with an extensive user base of teenage girls and young women. Verbal negotiations of sexual consent were frequently featured in these stories. However, several themes emerged to blur clear distinctions between the presence and lack of consent: hesitance or unease for sexual interactions, assumption of a partner’s sexual consent, unclear identification of sexual assault, language of attack or aggression to describe sexual interactions, and normalization of sexual actions that surprise a partner. A number of rape myths were also prevalent throughout the stories. The implications of these scripts for One Direction fans and for sexual scripting theory are discussed

Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells.

Affinity and dose of T cell receptor (TCR) interaction with antigens govern the magnitude of CD4+ T cell responses, but questions remain regarding the quantitative translation of TCR engagement into downstream signals. We find that while the response of mouse CD4+ T cells to antigenic stimulation is bimodal, activated cells exhibit analog responses proportional to signal strength. Gene expression output reflects TCR signal strength, providing a signature of T cell activation. Expression changes rely on a pre-established enhancer landscape and quantitative acetylation at AP-1 binding sites. Finally, we show that graded expression of activation genes depends on ERK pathway activation, suggesting that an ERK-AP-1 axis plays an important role in translating TCR signal strength into proportional activation of enhancers and genes essential for T cell function

Monocyte phenotypes: when local education counts

Monocytes are a heterogeneous population of phagocytic cells that are generated in the bone marrow and released into the bloodstream. There are two main monocyte subsets in mice: “inflammatory” monocytes that are Ly6Chi CCR2hi CX3 CR1low and “alternative” or “patrolling” monocytes that are Ly6Clow CCR2low CX3 CR1hi. The process of monocyte recruitment and differentiation is still a matter of controversy. In this issue, Dal-Secco et al. report in situ monocyte reprogramming in the liver, from proinflammatory CCR2hi CX3 CR1low cells into reparative CCR2low CX3 CR1hi cells and show, for the first time, that this occurs at the site of injury.Fil: Quintar, Amado Alfredo. la Jolla Institute For Allergy And Immunology; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Hedrick, Catherine C. . la Jolla Institute For Allergy And Immunology; Estados UnidosFil: Ley, Klaus. la Jolla Institute For Allergy And Immunology; Estados Unido

Projected northward shifts in eastern red-backed salamanders due to changing climate

This work was supported by a research grant to BPH from the Research Enhancement Program at Louisiana State University. AE was funded by Organismo Autónomo Parques Nacionales of Spain through project 2745/2021.Many species' distributions are being impacted by the acceleration of climate change. Amphibians in particular serve numerous ecosystem functions and are useful indicators of environmental change. Understanding how their distributions have been impacted by climate change and will continue to be impacted is thus important to overall ecosystem health. Plethodon cinereus (Eastern Red-Backed Salamander) is a widespread species of lungless salamander (Plethodontidae) that ranges across northeastern North America. To better understand future potential lungless salamander range shifts, we quantify environmental favorability, the likelihood of membership in a set of sites where environmental conditions are favorable for a species, for P. cinereus in multiple time periods, and examine shifts in the species' distribution. First, utilizing a large data set of georeferenced records, we assessed which bioclimatic variables were associated with environmental favorability in P. cinereus. We then used species distribution modeling for two time periods (1961-1980 and 2001-2020) to determine whether there was a regional shift in environmental favorability in the past 60 years. Models were then used to project future distributions under eight climate change scenarios to quantify potential range shifts. Shifts were assessed using fuzzy logic, avoiding thresholds that oversimplify model predictions into artificial binary outputs. We found that P. cinereus presence is strongly associated with environmental stability. There has been a substantial northward shift in environmental favorability for P. cinereus between 1961-1980 and 2001-2020. This shift is predicted to continue by 2070, with larger shifts under higher greenhouse gas emission scenarios. As climate change accelerates, it is differentially impacting species but has especially strong impacts on dispersal-limited species. Our results show substantial northward shifts in climatic favorability in the last 60 years for P. cinereus, which are likely to be exacerbated by ongoing climate change. Since P. cinereus is dispersal-limited, these models may imply local extirpations along the southern modern range with limited northward dispersal. Continued monitoring of amphibians in the field will reveal microclimatic effects associated with climate change and the accuracy of the model predictions presented here.Publisher PDFPeer reviewe

Disparities in access to fertility care in the united states: Ethical considerations for equitable solutions

There are significant disparities in access to fertility services in the United States. These disparities exist along lines of race, ethnicity, education, income, geographic location, marital status, gender identity, and sexual orientation. In this paper, I will argue that these inequalities represent inequities and therefore demand rectification. The disparities in access to care exist for certain groups with shared characteristics who are overall socially and historically disadvantaged. However, proposed solutions will also raise ethical issues that require careful consideration. For example, passing a policy that mandates insurance coverage of in vitro fertilization raises questions about eligibility, resource allocation, distributive justice and limitations on which reproductive technologies ought to be covered. Such a policy also fails to address barriers other than cost, such as geographic location and sociocultural factors, which may perpetuate existing disparities. Given that barriers to care include financial, geographical, and sociocultural factors, I will argue for the necessity of multifaceted solutions. I urge policymakers to also examine the distribution of benefits for policies under consideration. Ultimately, my investigation reveals that proposed solutions to reduce disparities in access to fertility care raise ethical issues of their own. These issues are not reasons for inaction, but rather ought to be carefully considered when evaluating policy solutions. I will conclude with recommendations for mitigating ethical concerns that arise from policies that aim to address disparities and outline the beginning of a solution to improve access to fertility care in the United States