The management of acute venous thromboembolism in clinical practice. Results from the European PREFER in VTE Registry

Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in Europe. Data from real-world registries are necessary, as clinical trials do not represent the full spectrum of VTE patients seen in clinical practice. We aimed to document the epidemiology, management and outcomes of VTE using data from a large, observational database. PREFER in VTE was an international, non-interventional disease registry conducted between January 2013 and July 2015 in primary and secondary care across seven European countries. Consecutive patients with acute VTE were documented and followed up over 12 months. PREFER in VTE included 3,455 patients with a mean age of 60.8 ± 17.0 years. Overall, 53.0 % were male. The majority of patients were assessed in the hospital setting as inpatients or outpatients (78.5 %). The diagnosis was deep-vein thrombosis (DVT) in 59.5 % and pulmonary embolism (PE) in 40.5 %. The most common comorbidities were the various types of cardiovascular disease (excluding hypertension; 45.5 %), hypertension (42.3 %) and dyslipidaemia (21.1 %). Following the index VTE, a large proportion of patients received initial therapy with heparin (73.2 %), almost half received a vitamin K antagonist (48.7 %) and nearly a quarter received a DOAC (24.5 %). Almost a quarter of all presentations were for recurrent VTE, with >80 % of previous episodes having occurred more than 12 months prior to baseline. In conclusion, PREFER in VTE has provided contemporary insights into VTE patients and their real-world management, including their baseline characteristics, risk factors, disease history, symptoms and signs, initial therapy and outcomes

Structural controls and metallogenic model of polyphase uranium mineralization in the Kiggavik area (Nunavut, Canada)

The Kiggavik area is located on the eastern boundary of the Paleo- to Mesoproterozoic Thelon Basin (Nunavut, Canada) and hosts uranium mineralization in Archean basement rocks. The major fault/fracture network in the Kiggavik area is mainly oriented ENE-WSW and NE-SW, consisting of polyphased fault zones initiated during the Thelon and Trans-Hudsonian orogenies (ca. 1900-1800 Ma). These faults were subsequently mineralized in four stages referred to as U0, U1, U2, and U3. The first event U0 is inferred to be of magmatic origin and is related to microbrecciation and weak clay alteration under a WSW-ENE σ1. U0 is a ca. 1830 event which predates intense quartz brecciation (QB) and veining at ca. 1750 Ma. QB is associated with emplacement of the Kivalliq Igneous Suite and caused pervasive silicification of former fault zones, which in turn controlled subsequent fracture development and behaved as barriers for later U mineralizing fluids (U1 to U3). U1, U2, and U3 postdate deposition of the Thelon Basin. U1 and U2 occurred under a regional strike-slip stress regime, with the direction of σ1 evolving from WNW-ESE (U1) to NE-SW /ENE-WSW (U2); both formed at ~ 1500-1330 Ma and are related to circulation of Thelon-derived uranium-bearing basinal brines. A post U2, but pre-Mackenzie dykes (ca. 1270 Ma), extensional/transtensional stress regime with σ3 oriented NE-SW caused normal-dextral offset of the orebodies by reactivating NNW-SSE and E-W trending faults. This fracturing event triggered circulation of hot (~ 300 °C), probably acidic, fluids that dissolved quartz, and caused illitization and bleaching of the host rocks. Finally, U3 records remobilization of the previous mineralization along redox fronts through percolation of low-temperature meteoric fluids during two main tectonic events at ca. 550 and 350 Ma. This study provides evidences for the presence of a primary, pre-Thelon Basin uranium stock within the Kiggavik prospects, and a strong structural control on mineralization in the Kiggavik area. Our study also shows a nearly similar evolution of uranium mineralization in this area compared to the world-class uranium district of the Athabasca Basin (Saskatchewan, Canada)

Sealing capacity of clays in multilayer systems : a field study of fracture-fluid flow relationships (Blue Clay formation, Maltese Islands)

International audienc

Sealing capacity of clays in multilayer systems : a field study of fracture-fluid flow relationships (Blue Clay formation, Maltese Islands)

International audienc

Impact of Leave-on Skin Care Products on the Preservation of Skin Microbiome: An Exploration of Ecobiological Approach

Sylvie Callejon,1,2 Félix Giraud,1,2 Florence Larue,1 Armonie Buisson,1 Léa Mateos,1,2 Laurence Grare,1 Aurélie Guyoux,1 Eric Perrier,2 Nathalie Ardiet,1 Sandra Trompezinski1,2 1NAOS Group, Research and Development Department, Aix-en-Provence, France; 2NAOS Institute of Life Science, Aix-en-Provence, FranceCorrespondence: Sandra Trompezinski, 355 Rue Pierre Simon Laplace, 13593 Aix-en-Provence Cedex 03, Aix-en-Provence, France, Tel +33 4 42 60 73 65, Email [email protected]: Skincare products are used daily to maintain a healthy skin, although their skin microbiome impact is still poorly known. Preserving the natural resources and mechanisms of the skin ecosystem is essential, and a novel approach based on these premises, called ecobiology, has recently emerged in skincare. We evaluated the impact on the skin microbiome of three types of leave-on face skincare products: a hydrophilic solution, a micellar solution, and an oil-in-water emulsion.Patients and Methods: Samples for microbial profiling were obtained from 20 Caucasian females twenty-four hours and four days following daily application of the skincare products and compared to an untreated area. The bacterial diversity and the abundance of the skin microbiome were analyzed by 16S rRNA gene sequencing using an Illumina MiSeq platform.Results: Our results confirmed the skin microbiome diversity and the prevalence of Cutibacterium spp. and Staphylococcus spp. at sebaceous sites. The bacterial diversity and abundance were not affected by the products, and no dissimilarities versus the control nor between each product were noted at both times.Conclusion: These preliminary results demonstrate for the first time that three types of leave-on face skincare products have no impact on the human skin microbiome and can be considered to be “microbiome friendly”.Keywords: cosmetic product, ecobiology, microbiome friendl

Interpretation and knowledge of human rights in mental health practice

The Human Rights Act is sometimes misunderstood as being an obstruction to the provision of safe and effective mental health care, allowing patients to cry 'human rights abuse' too easily. In reality, however, little is known about how human rights are protected and promoted in psychiatric care. This article provides an overview, for nurses, of how human rights are currently understood to be protected in mental health care and steps that could improve the protection of rights. Additionally, an overview of the relevant case law is presented to enable nurses to understand how human rights law is ever-evolving, how cases may be interpreted, and the implications that this has for mental health nursing practice