8,293 research outputs found

    “One More for Luck”: The Destruction of U971 by HMCS Haida and HMS Eskimo, 24 June 1944

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    On the evening of 23 June 1944, HMCS Haida and HMS Eskimo set out from Plymouth, operational base of the 10th Destroyer Flotilla (10th DF), to conduct a sweep of the Western Approaches to the English Channel. Their role was to assist in securing these waters for the ongoing delivery of supplies and reinforcements to the Normandy bridgehead. Across the Channel to the southest, American, British and Canadian forces were now in their third week of fighting across the fields and hedgerows of Normandy. Operation OVERLORD had been the largest amphibious invasion in history and, dependent as it was on the unimpeded use of the sea, required an intensive concentration of air and naval forces to protect Allied supply convoys. This naval counterpart of OVERLORD was Operation NEPTUNE, and it was as part of this massive undertaken that Haida and Eskimo now steamed out of Plymouth

    STEM policy and science education: Scientistic curriculum and sociopolitical silences

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    This essay responds to the contribution of Volny Fages and Virginia Albe, in this volume, to the field of research in science education, and places it in the context of the plethora of government and industry policy documents calling for more Science, Technology, Engineering and Mathematics (STEM) education in schools and universities and the tension between these and students' declining interest in studying STEM subjects. It also draws attention to the parallels between the silences around sociopolitical issues in government policies and curriculum related to STEM, including nanoscience, and those found with respect to environmental education two decades ago, and relates these to the resurgence of a scientific rationalist approach to curriculum

    Optimal Masks for Low-Degree Solar Acoustic Modes

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    We suggest a solution to an important problem of observational helioseismology of the separation of lines of solar acoustic (p) modes of low angular degree in oscillation power spectra by constructing optimal masks for Doppler images of the Sun. Accurate measurements of oscillation frequencies of low-degree modes are essential for the determination of the structure and rotation of the solar core. However, these measurements for a particular mode are often affected by leakage of other p modes arising when the Doppler images are projected on to spherical-harmonics masks. The leakage results in overlaping peaks corresponding to different oscillation modes in the power spectra. In this paper we present a method for calculating optimal masks for a given (target) mode by minimizing the signals of other modes appearing in its vicinity. We apply this method to time series of 2 years obtained from Michelson Doppler Imager (MDI) instrument on board SOHO space mission and demonstrate its ability to reduce efficiently the mode leakage.Comment: to be published in Astrophys.J. Letter

    Sustainable Schools in the UN Decade of Education for Sustainable Development: Meeting the challenge?

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    Within UNESCO’s conception of Education for Sustainable Development (ESD), schools should be implementing approaches to teaching and learning that integrate goals for conservation, social justice, appropriate  development and democracy into a vision and a mission of personal and social change. ESD also involves  developing the kinds of civic virtues and skills that can empower all citizens and, through them, our social  institutions, to play leading roles in the transition to a sustainable future. As such, ESD encompasses a vision for global society that is not only ecologically sustainable but also one that is socially and economically  sustainable. This paper traces the history of ESD in Victorian schools and analyses the current sustainability policies and initiatives in terms of their achievement of the educational, environmental, economic and social indicators of ESD. It also problematises the feasibility, and desirability, of any one programme being able to incorporate all aspects of ESD as elaborated by UNESCO

    Genomic structure and cloning of two transcript isoforms of human Sp8

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    BACKGROUND: The Specificity proteins (Sp) are a family of transcription factors that have three highly conserved zinc-fingers located towards the carboxy-terminal that bind GC-boxes and assist in the initiation of gene transcription. Human Sp1-7 genes have been characterized. Recently, the phenotype of Sp8 null mice has been described, being tailless and having severe truncation of both fore and hind limbs. They also have malformed brains with defective closure of the anterior and posterior neuropore during brain development. RESULTS: The human Sp8 gene is a three-exon gene that maps to 7p21.3, close to the related Sp4 gene. From an osteosarcoma cell line we cloned two transcript variants that use two different first exons and have a common second exon. One clone encodes a 508-residue protein, Sp8L (isoform 1) and the other a shorter 490-residue protein, Sp8S (isoform 2). These two isoforms are conserved being found also in mice and zebrafish. Analysis of the Sp8L protein sequence reveals an amino-terminal hydrophobic Sp-motif that is disrupted in Sp8S, a buttonhead box and three C(2)H(2 )zinc-fingers. Sp8 mRNA expression was detected in a wide range of tissues at a low level, with the highest levels being found in brain. Treatment of the murine pluripotent cell line C3H10T1/2 with 100 ng/mL BMP-2 induced Sp8 mRNA after 24 hours. CONCLUSIONS: There is conservation of the two Sp8 protein isoforms between primates, rodents and fish, suggesting that the isoforms have differing roles in gene regulation. Sp8 may play a role in chondrogenic/osteoblastic differentiation in addition to its role in brain and limb development
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