Charged-current inclusive neutrino cross sections in the SuperScaling model including quasielastic, pion production and meson-exchange contributions

Charged current inclusive neutrino-nucleus cross sections are evaluated using the superscaling model for quasielastic scattering and its extension to the pion production region. The contribution of two-particle-two-hole vector meson-exchange current excitations is also considered within a fully relativistic model tested against electron scattering data. The results are compared with the inclusive neutrino-nucleus data from the T2K and SciBooNE experiments. For experiments where $\langle E_\nu \rangle \sim 0.8$ GeV, the three mechanisms considered in this work provide good agreement with the data. However, when the neutrino energy is larger, effects from beyond the $\Delta$ also appear to be playing a role. The results show that processes induced by two-body currents play a minor role at the kinematics considered.Comment: 10 pages, 7 figure

Superscaling in the resonance region for neutrino-nucleus scattering: The SuSAv2-DCC model

In this work the SuSAv2 and dynamical coupled-channels (DCC) models have been combined and tested in the inelastic regime for electron and neutrino reactions on nuclei. The DCC model, an approach to study baryon resonances through electron and neutrino induced meson production reactions, has been implemented for the first time in the SuSAv2-inelastic model to analyze the resonance region. Within this framework, we also present a novel description about other inelasticities in the resonance region (SoftDIS). The outcomes of these approaches are firstly benchmarked against (e,e') data on 12C. The description is thus extended to the study of neutrino-nucleus inclusive cross sections on 12C and 40Ar and compared with data from the T2K, MicroBooNE, ArgoNEUT and MINERvA experiments, thus covering a wide kinematical range.Comment: Submitted to Physical Review

Meson-exchange currents and quasielastic predictions for charged-current neutrino-12C scattering in the superscaling approach

We evaluate and discuss the impact of meson-exchange currents (MECs) on charged-current quasielastic neutrino cross sections. We consider the nuclear transverse response arising from two-particle two-hole states excited by the action of electromagnetic, purely isovector meson-exchange currents in a fully relativistic framework based on the work by the Torino Collaboration [A. D. Pace, M. Nardi, W. M. Alberico, T. W. Donnelly, and A. Molinari, Nucl. Phys. A726, 303 (2003)]. An accurate parametrization of this MEC response as a function of the momentum and energy transfers involved is presented. Results of neutrino-nucleus cross sections using this MEC parametrization together with a recent scaling approach for the one-particle one-hole contributions (named SuSAv2) are compared with experimental data (MiniBooNE, MINERvA, NOMAD and T2K Collaborations).Comment: 16 pages, 19 figure

Testing nuclear models via neutrino scattering

Recent progresses on the relativistic modeling of neutrino-nucleus reactions are presented and the results are compared with high precision experimental data in a wide energy range.Comment: 10 pages, 5 figures, Proccedings of the 33rd International Workshop on Nuclear Theory, IWNT33-14, Rila Mountains, Bulgaria, June 22-28, 201

Phosphoproteomic analysis of neoadjuvant breast cancer suggests that increased sensitivity to paclitaxel is driven by CDK4 and filamin A

Precision oncology research is challenging outside the contexts of oncogenic addiction and/or targeted therapies. We previously showed that phosphoproteomics is a powerful approach to reveal patient subsets of interest characterized by the activity of a few kinases where the underlying genomics is complex. Here, we conduct a phosphoproteomic screening of samples from HER2-negative female breast cancer receiving neoadjuvant paclitaxel (N = 130), aiming to find candidate biomarkers of paclitaxel sensitivity. Filtering 11 candidate biomarkers through 2 independent patient sets (N= 218) allowed the identification of a subgroup of patients characterized by high levels of CDK4 and filamin-A who had a 90% chance of achieving a pCR in response to paclitaxel. Mechanistically, CDK4 regulates filamin-A transcription, which in turn forms a complex with tubulin and CLIP-170, which elicits increased binding of paclitaxel to microtubules, microtubule acetylation and stabilization, and mitotic catastrophe. Thus, phosphoproteomics allows the identification of explainable factors for predicting response to paclitaxel

Disruption of Ant-Aphid Mutualism in Canopy Enhances the Abundance of Beetles on the Forest Floor

Ant-aphid mutualism is known to play a key role in the structure of the arthropod community in the tree canopy, but its possible ecological effects for the forest floor are unknown. We hypothesized that aphids in the canopy can increase the abundance of ants on the forest floor, thus intensifying the impacts of ants on other arthropods on the forest floor. We tested this hypothesis in a deciduous temperate forest in Beijing, China. We excluded the aphid-tending ants Lasius fuliginosus from the canopy using plots of varying sizes, and monitored the change in the abundance of ants and other arthropods on the forest floor in the treated and control plots. We also surveyed the abundance of ants and other arthropods on the forest floor to explore the relationships between ants and other arthropods in the field. Through a three-year experimental study, we found that the exclusion of ants from the canopy significantly decreased the abundance of ants on the forest floor, but increased the abundance of beetles, although the effect was only significant in the large ant-exclusion plot (80*60 m). The field survey showed that the abundance of both beetles and spiders was negatively related to the abundance of ants. These results suggest that aphids located in the tree canopy have indirect negative effects on beetles by enhancing the ant abundance on the forest floor. Considering that most of the beetles in our study are important predators, the ant-aphid mutualism can have further trophic cascading effects on the forest floor food web

The SuSAv2 model for inelastic neutrino-nucleus scattering

The susperscaling model SuSAv2, already available for charged-current neutrino-nucleus cross sections in the quasielastic region, is extended to the full inelastic regime. In the model the resonance production and deep inelastic reactions are described through the extension to the neutrino sector of the SuSAv2 inelastic model developed for ($e,e'$) reactions, which combines phenomenological structure functions with a nuclear scaling function. This work also compares two different descriptions of the $\Delta$ resonance region, one based on a global scaling function for the full inelastic spectrum and the other on a semi-phenomenological $\Delta$ scaling function extracted from ($e,e'$) data for this specific region and updated with respect to previous work. The results of the model are tested against ($e,e'$) data on $^{12}$C, $^{16}$O, $^{40}$Ca and $^{40}$Ar and applied to the study of the charged current inclusive neutrino cross-section on $^{12}$C and $^{40}$Ar measured by the T2K, MicroBooNE, ArgoNEUT and MINERvA experiments, thus covering several kinematical regions.Comment: Submitted to Physical Review