Circadian and Metabolic Effects of Light: Implications in Weight Homeostasis and Health

Daily interactions between the hypothalamic circadian clock at the suprachiasmatic nucleus (SCN) and peripheral circadian oscillators regulate physiology and metabolism to set temporal variations in homeostatic regulation. Phase coherence of these circadian oscillators is achieved by the entrainment of the SCN to the environmental 24-h light:dark (LD) cycle, coupled through downstream neural, neuroendocrine, and autonomic outputs. The SCN coordinate activity and feeding rhythms, thus setting the timing of food intake, energy expenditure, thermogenesis, and active and basal metabolism. In this work, we will discuss evidences exploring the impact of different photic entrainment conditions on energy metabolism. The steady-state interaction between the LD cycle and the SCN is essential for health and wellbeing, as its chronic misalignment disrupts the circadian organization at different levels. For instance, in nocturnal rodents, non-24 h protocols (i.e., LD cycles of different durations, or chronic jet-lag simulations) might generate forced desynchronization of oscillators from the behavioral to the metabolic level. Even seemingly subtle photic manipulations, as the exposure to a "dim light" scotophase, might lead to similar alterations. The daily amount of light integrated by the clock (i.e., the photophase duration) strongly regulates energy metabolism in photoperiodic species. Removing LD cycles under either constant light or darkness, which are routine protocols in chronobiology, can also affect metabolism, and the same happens with disrupted LD cycles (like shiftwork of jetlag) and artificial light at night in humans. A profound knowledge of the photic and metabolic inputs to the clock, as well as its endocrine and autonomic outputs to peripheral oscillators driving energy metabolism, will help us to understand and alleviate circadian health alterations including cardiometabolic diseases, diabetes, and obesity.Fil: Plano, Santiago Andrés. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; ArgentinaFil: Casiraghi, Leandro Pablo. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Garcia Moro, Paula. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Paladino, Natalia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Golombek, Diego Andrés. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Chiesa, Juan José. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Las fronteras (étnicas) de la nación y los tropos del nacionalismo

Sin resume

On the origin of the jet-like radio/X-ray morphology of G290.1-0.8

The origin and evolution of supernova remnants of the mixed-morphology class is not well understood. Several remnants present distorted radio or X-ray shells with jet-like structures. G290.1-0.8 (MSH 11-61A) belongs to this class. We aim to investigate the nature of this supernova remnant in order to unveil the origin of its particular morphology. We based our work on the study of the X-ray emitting plasma properties and the conditions imposed by the cold interstellar medium where the remnant expanded. We use archival radio, HI line data and X-ray observations from XMM-Newton and Chandra observatories, to study G290.1-0.8 and its surrounding medium. Spatially resolved spectral analysis and mean photon energy maps are used to obtain physical and geometrical parameters of the source. Radio continuum and HI line maps give crucial information to understand the radio/X-ray morphology. The X-ray images show that the remnant presents two opposite symmetric bright spots on a symmetry axis running towards the NW-SE direction. Spectral analysis and mean photon energy maps confirm that the physical conditions of the emitting plasma are not homogeneous throughout the remnant. In fact, both bright spots have higher temperatures than the rest of the plasma and its constituents have not reached ionization equilibrium yet. HI line data reveal low density tube-like structures aligned along the same direction. This evidence supports the idea that the particular X-ray morphology observed is a direct consequence of the structure of the interstellar medium where the remnant evolved. However, the possibility that an undetected point-like object, as a neutron star, exists within the remnant and contributes to the X-ray emission cannot be discarded. Finally, we suggest that a supernova explosion due to the collapse of a high-mass star with a strong bipolar wind can explain the supernova remnant morphology.Comment: 8 pages, 6 figures. Accepted for publication in A&

Chloroplast fructose-1,6-bisphosphatase: Modification of non-covalent interactions promote the activation by chimeric Escherichia coli thioredoxins

AbstractAlthough all thioredoxins contain a highly conserved amino acid sequence responsible for thiol/disulfide exchanges, only chloroplast thioredoxin-f is effective in the reductive stimulation of chloroplast fructose- 1,6-bisphosphatase. We set out to determine whether Escherichia coli thioredoxin becomes functional when selected modulators alter the conformation of the target enzyme. Wild type and chimeric Escherichia coli thioredoxins match the chloroplast counterpart when the activation of chloroplast fructose- 1,6-bssphosphatase is performed in the presence of fructose 1,6-bisphosphate, Ca2+, and either trichloroacetate or 2-propanol. These modulators of enzyme activity do change the conformation of chloroplast fructose-1,6-bisphosphatase whereas bacterial thioredoxins remain unaltered. Given that fructose 1,6-bisphosphate, Ca2+, and non-physiological perturbants modify non-covalent interactions of the protein but do not participate in redox reactions, these results strongly suggest that the conformation of the target enzyme regulates the rate of thiol/disulfide exchanges catalyzed by protein disulfide oxidoreductases

Hollow Au/Ag nanostars displaying broad plasmonic resonance and high surface-enhanced Raman sensitivity

9 pas.; 7 figs.; 2 tabs.This journal is © The Royal Society of Chemistry. Bimetallic Au/Ag hollow nanostar (HNS) nanoparticles with different morphologies were prepared in this work. These nanoplatforms were obtained by changing the experimental conditions (concentration of silver and chemical reductors, hydroxylamine and citrate) and by using Ag nanostars as template nanoparticles (NPs) through galvanic replacement. The goal of this research was to create bimetallic Au/Ag star-shaped nanoparticles with advanced properties displaying a broader plasmonic resonance, a cleaner exposed surface, and a high concentration of electromagnetic hot spots on the surface provided by the special morphology of nanostars. The size, shape, and composition of Ag as well as their optical properties were studied by extinction spectroscopy, hyperspectral dark field microscopy, transmission and scanning electron microscopy (TEM and SEM), and energy dispersive X-ray spectroscopy (EDX). Finally, the surface-enhanced Raman scattering (SERS) activity of these HNS was investigated by using thioflavin T, a biomarker of the β-amyloid fibril formation, responsible for Alzheimer's disease. Lucigenin, a molecule displaying different SERS activities on Au and Ag, was also used to explore the presence of these metals on the NP surface. Thus, a relationship between the morphology, plasmon resonance and SERS activity of these new NPs was made.This work has been supported by the Spanish Ministerio de Economía y Competitividad (MINECO, grant FIS2014-52212- R). A. G.-L. acknowledges CSIC and FSE 2007–2013 for a JAE-CSIC predoctoral grant.Peer Reviewe

Identifying past social-ecological thresholds to understand long-term temporal dynamics in Spain

A thorough understanding of long-term temporal social-ecological dynamics at the national scale helps to explain the current condition of a country’s ecosystems and to support environmental policies to tackle future sustainability challenges. We aimed to develop a methodological approach to understand past long-term (1960-2010) social-ecological dynamics in Spain. First, we developed a methodical framework that allowed us to explore complex social-ecological dynamics among biodiversity, ecosystem services, human well-being, drivers of change, and institutional responses. Second, we compiled 21 long-term, national-scale indicators and analyzed their temporal relationships through a redundancy analysis. Third, we used a Bayesian change point analysis to detect evidence of past social-ecological thresholds and historical time periods. Our results revealed that Spain has passed through four socialecological thresholds that define five different time periods of nature and society relationships. Finally, we discussed how the proposed methodological approach helps to reinterpret national-level ecosystem indicators through a new conceptual lens to develop a more systems-based way of understanding long-term social-ecological patterns and dynamicsThis work was supported by the Biodiversity Foundation (http://www.fundacion-biodiversidad.es/) of the Spanish Ministry of Agriculture, Food and Environment. Partial financial support was also provided by the Ministry of Economy and Competitiveness of Spain (project CGL2014-53782-P: ECOGRADIENTES). The Spanish National Institute for Agriculture and Food Research and Technology (INIA) funded Marina García-Llorente as part of the European Social Fund. Blanca González García-Mon participated in this article as a “la Caixa” Banking Foundation scholar. The funders had no role in the study design, data collection and analysis, preparation of the report, or the decision to submit the study for publicatio

El proceso de secularización: apuntes sobre el cambio histórico de la religión a la ciencia

This paper focuses on one among the various dimensions of the process of secularization, namely, the secularization of knowledge. Firstly, the paper explores Durkheim's and Weber's classic theories of the secularization of knowledge. Secondly, it discusses some of the most common explanations of this process that point out a continuity between sacred and secular knowledge, respectively. Finally, it proposes an interpretation of the process of secularization of knowledge in terms of the principie of "heterogony of purposes".Este artículo se centra en una de las dimensiones del proceso de secularización: la secularización del conocimiento. En primer lugar, el artículo muestra las teorías clásicas de E. Durkheim y M. Weber sobre este proceso. En segundo lugar, se destacan algunas de las más importantes explicaciones que señalan la continuidad entre el saber sagrado y el saber secular. Por último, se propone una interpretación del proceso de secularización del conocimiento por medio del principio de la "heterogonía de los fines"