Aircraft aerodynamic prediction method for V/STOL transition including flow separation

A numerical procedure was developed for the aerodynamic force and moment analysis of V/STOL aircraft operating in the transition regime between hover and conventional forward flight. The trajectories, cross sectional area variations, and mass entrainment rates of the jets are calculated by the Adler-Baron Jet-in-Crossflow Program. The inviscid effects of the interaction between the jets and airframe on the aerodynamic properties are determined by use of the MCAIR 3-D Subsonic properties are determined by use of the MCAIR 3-D Subsonic Potential Flow Program, a surface panel method. In addition, the MCAIR 3-D Geometry influence Coefficient Program is used to calculate a matrix of partial derivatives that represent the rate of change of the inviscid aerodynamic properties with respect to arbitrary changes in the effective wing shape

Interactive Influence of Turbidity and Light on Larval Bluegill (Lepomis macrochirus) Foraging

Abstract in English and French.In a series of in situ enclosure experiments with larval bluegill (lepomis macrochirus), we demonstrate that turbidity from suspended sediments reduces bluegill consumption of crustacean zooplankton, primarily cyclopoid copepods and cogepod nauplii. However, this reduction occurred only when light intensity in parts of enclosures fell below a threshold, estimated at <450 lx. Following recent studies demonstrating copepod die1 vertical migration in response to predators, it appears that copepods in our experiments used low-light strata as a refuge. Without this apparent refuge present, larval bluegill consumption increased with increasing turbidity, but prey were smaller on average. Thus, prey biomass consumed by larval bluegill did not differ with turbidity in high-light conditions. We postulate that the shift to smaller prey across taxa at higher turbidity, when light intensity exceeded 450 lx, derives from increased prey-background contrast. In low-light conditions, larval bluegill consumed larger, but fewer, zooplankton with increasing turbidity, resulting in lower prey biomass consumed. Thus, we demonstrate the field conditions causing negative turbidity effects on larval fish foraging success, and thus growth and recruitment.This research was supported in part by National Science Foundation grants BSR-8715730 and BSR-9107173 to R. A. Stein and Sigma Xi Grants-in-Aid-of-Research to J. G. Miner

Stocking Threadfin Shad: Consequences for Young-of-Year Fishes

Threadfin shad Dorosoma petenense are commonly introduced into reservoirs to supplement prey available to piscivorous fishes. To determine how early life stages of threadfin shad and their potential competitors and predators interact, we introduced this species into two Ohio lakes—Clark and Stonelick—and evaluated how its young of year influenced young-of-year bluegills Lepomis macrochirus and largemouth bass Micropterus salmoides. After adults were stocked in April, peak abundance of young-of-year threadfin shad occurred in August in both lakes. Bluegills generally spawned earlier than threadfin shad, which apparently reduced competition between young of these species. In Clark Lake, young-of-year threadfin shad did not reduce zooplankton populations, but in Stonelick Lake, peak abundance of young-of-year threadfin shad was followed by a precipitous decline in zooplankton. Data on cladoceran birth rates indicated this decline was due to increased predation by threadfin shad. Survival of bluegills to a size at which they move into the littoral zone also declined in Stonelick Lake, perhaps because of the virtual elimination of zooplankton. Limited survival of bluegills in turn contributed to reduced growth of young-of-year largemouth bass dependent on them as prey. Given that zooplankton declined in one but not the other lake, interactions among young-of-year fishes due to annually introduced threadfin shad will likely vary among systems and years. Nonetheless, introduced threadfin shad could, in some systems in some years, negatively affect growth and recruitment of the very species they were meant to enhance.This work was funded in part by National Science Foundation grants NSF BSR-8705518 to R. A. Stein and NSF BSR-8715730 to G. G. Mittelbach, and by Federal Aid in Fish Restoration Project F-57-R awarded to R. A. Stein and administered through the Ohio Division of Wildlife

The anti-emetic potential of the 5-hydroxytryptamine3 receptor antagonist BRL 43694.

In ferrets, the selective 5-hydroxytryptamine (5-HT) 5-HT3 receptor antagonist BRL 43694 given as a single injection (0.05-0.5 mg kg-1 i.v.) before cisplatin, or by divided dose (2 x 0.005-2 x 0.5 mg kg-1 i.v.) before and after cisplatin dramatically reduced or abolished the severe cisplatin-induced vomiting. BRL 43694 also substantially reduced the vomiting induced by cyclophosphamide:doxorubicin, and prevented the trimelamol-induced emesis. The severe emesis caused by whole body exposure to X-irradiation was prevented by intravenous or oral BRL 43694. A single i.v. dose of BRL 43694 given during an emetic episode or within the peak emetic period, abolished the vomiting induced by the cytotoxic drugs and by X-irradiation, usually within 30 s. Where the induction of emesis was prevented or subsequently abolished by BRL 43694, the associated behaviour (subjectively assessed as nausea) was also absent or greatly attenuated. BRL 43694 (0.1 mg kg-1 i.v.) did not affect the emesis evoked in dogs by the dopamine agonist apomorphine. The potent anti-emetic activity of BRL 43694 is discussed in terms of potential clinical use, and of the fundamental role that 5-HT3 receptors may play in the mechanisms of nausea and vomiting

Energetic Adaptations along a Broad Latitudinal Gradient: Implications for Widely Distributed Assemblages

Most community-based models in ecology assume that all individuals within a species respond similarly to environmental conditions and thereby exert identical effects as consumers or prey. Rather, individuals differ among systems, with important implications for population demographics and community interactions. For widely distributed assemblages made up of poikilotherms with high first-year mortality, species-specific differences in growth reaction norms as affected by both temperature and genotype will influence biotic interactions. For a broadly distributed fish assemblage, first-year growth does not vary with latitude for a planktivorous prey species, but declines with increasing latitude for a terminal piscivore. Size-based competitive interactions between these species are likely to be more intense at high latitudes, as they spend an extended time sharing resources during early life. Such patterns probably are pervasive and must be considered when seeking to understand species interactions. Improving our knowledge of how temperature and local adaptations affect size-based interactions should enhance our ability to manage and conserve widespread assemblages

Baseline Assessment and Prioritization Framework for IVHM Integrity Assurance Enabling Capabilities

Fundamental to vehicle health management is the deployment of systems incorporating advanced technologies for predicting and detecting anomalous conditions in highly complex and integrated environments. Integrated structural integrity health monitoring, statistical algorithms for detection, estimation, prediction, and fusion, and diagnosis supporting adaptive control are examples of advanced technologies that present considerable verification and validation challenges. These systems necessitate interactions between physical and software-based systems that are highly networked with sensing and actuation subsystems, and incorporate technologies that are, in many respects, different from those employed in civil aviation today. A formidable barrier to deploying these advanced technologies in civil aviation is the lack of enabling verification and validation tools, methods, and technologies. The development of new verification and validation capabilities will not only enable the fielding of advanced vehicle health management systems, but will also provide new assurance capabilities for verification and validation of current generation aviation software which has been implicated in anomalous in-flight behavior. This paper describes the research focused on enabling capabilities for verification and validation underway within NASA s Integrated Vehicle Health Management project, discusses the state of the art of these capabilities, and includes a framework for prioritizing activities

Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation.

Activation of the NLRP3 inflammasome by microbial ligands or tissue damage requires intracellular generation of reactive oxygen species (ROS). We present evidence that macrophage secretion of IL1β upon stimulation with ATP, crystals or LPS is mediated by a rapid increase in the activity of xanthine oxidase (XO), the oxidized form of xanthine dehydrogenase, resulting in the formation of uric acid as well as ROS. We show that XO-derived ROS, but not uric acid, is the trigger for IL1β release and that XO blockade results in impaired IL1β and caspase1 secretion. XO is localized to both cytoplasmic and mitochondrial compartments and acts upstream to the PI3K-AKT signalling pathway that results in mitochondrial ROS generation. This pathway represents a mechanism for regulating NLRP3 inflammasome activation that may have therapeutic implications in inflammatory diseases