Possibilities of correction of lipid-phospholipid disorders in patients with non-alcoholic steatohepatitis against obesity and pathology of the biliary tract.

High priority in the pathogenesis and treatment of non-alcoholic steatohepatitis (NASH) is given to disorders of lipid-phospholipid fractions, which are directly related to the functioning of hepatocytes. The aim of the study was to evaluate the effect of various complex treatment regimens on lipid-phospholipid fractions in patients with NASH in combination with obesity (OB) and pathology of the biliary tract (BT) according to a 6-month follow-up. 52 patients with NASH in combination with OB and BT pathology were examined. The control group consisted of 20 practically healthy individuals. The effect of complex treatment (preventive and therapeutic measures) on the indicators of lipid-phospholipid fractions in patients with NASH in combination with obesity and pathology of the biliary tract was studied. Changes in the indicators of serum lipid-phospholipid fractions were detected before treatment in all observation groups, which were accompanied by decrease in phospholipids (PL), phosphatidylcholine and sphingomyelin content and a significant increase in PL lysoforms – lysophosphatidylcholine and phosphatidylethanolamine, triglycerides, cholesterol esters (from p<0.05 to p<0.001). Combination therapy with the inclusion in the standard treatment of ursodeoxycholic acid and arginine glutamate in the comorbid course of NASH can be considered as a promising direction in the treatment of this category of patients, this allows to improve indicators of lipid-phospholipid fractions and stabilize the hepatocytes’ membrane (from p<0.05 to p<0.001)

Studying temporal variability of GRS1739-278 during the 2014 outburst

We report a discovery of low-frequency quasi periodic oscillation at 0.3-0.7 Hz in the power spectra of the accreting black hole GRS1739-278 in the hard-intermediate state during its 2014 outburst based on the ${\it NuSTAR}$ and Swift/XRT data. The QPO frequency strongly evolved with the source flux during the NuSTAR observation. The source spectrum became softer with rising QPO frequency and simultaneous increasing of the power-law index and decreasing of the cut-off energy. In the power spectrum, a prominent harmonic is clearly seen together with the main QPO peak. The fluxes in the soft and the hard X-ray bands are coherent, however, the coherence drops for the energy bands separated by larger gaps. The phase-lags are generally positive (hard) in the 0.1-3 Hz frequency range, and negative below 0.1 Hz. The accretion disc inner radius estimated with the relativistic reflection spectral model appears to be $R_{\rm in} < 7.3 R_{\rm g}$. In the framework of the relativistic precession model, in order to satisfy the constraints from the observed QPO frequency and the accretion disc truncation radius, a massive black hole with $M_{\rm BH} \approx 100$M$_\odot$ is required.Comment: 15 pages, 12 figures; accepted for publication in MNRA

Dynamical vector-valued optimization of complex adaptive control of retail unit of a commercial bank

In this article discusses current issues of optimizing the management of the retail unit of a commercial bank in order to improve the economic efficiency and competitiveness of the bank. The article presents the method of solving a multi-step dynamical problem of complex adaptive control of the number of employees and sales of the Bank's Retail Unit with a vector quality criterion for the control process under consideration. For the organization of optimal adaptive terminal control of the system under study, a recurrent algorithm is proposed, which reduces the initial multi-step problem to the realization of a finite sequence of tasks for an optimal program terminal control. On the basis of the developed computer simulation system and the results of computer simulation, the choice of the optimal solution for the optimization problem under consideration was made. The proposed approach allows us to develop management solutions based on the availability of current information support, that is, using the feedback principle, aimed at creating the optimal number of employees and the sales system of the Bank's Retail Unit, which helps optimize profits and gain competitive advantages for the bank. © 2019 Author(s).Russian Foundation for Basic Research, RFBR: 17-01-00315, 18-01-00544This work was supported by the Russian Basic Research Foundation, projects no. 17-01-00315, and no. 18-01-00544

Application of dynamic economic-mathematical modeling in optimization problems in banking

The topical issues of optimizing the management of banking in order to increase the economic efficiency and competitiveness of the bank are discussed. To solve the problem of optimizing the management of the number of employees and sales of the Bank's Retail Unit, it is proposed to use dynamic economic and mathematical modeling that takes into account the presence of control actions and a vector quality criterion. The criterion of quality is the indicator Cost Income Ratio (CIR) - the ratio of operating costs to operating income. CIR is actively used around the world to assess the effectiveness of the bank by investors, shareholders, rating agencies. The report presents the main stages in the development of the considered dynamic model. An algorithm for solving the posed optimization problem is proposed. Based on the developed computer modeling system and the results of computer modeling, the optimal solution for the optimization problem under consideration was chosen. The paper illustrates all the results obtained and analyzes them. The developed model and method for solving the problem of optimizing the management of the number of employees and sales of the Bank's Retail Unit can serve as a basis for the development, creation and application of appropriate computer information systems to support the adoption of managerial decisions in banking. © 2018 Author(s).This work was supported by the Russian Basic Research Foundation, projects no. 17-01-00315, and no. 18-01-00544

Non-alcoholic and alcoholic fatty liver disease in patients suffering from biliary tract pathology and obesity: clinical and functional aspects

Fatty liver disease of different genesis is very often accompanied by biliary tract pathology and obesity. Clinical and functional characteristics of the fatty liver disease with accompanying biliary tract and obesity pathology include intensity of clinical manifestation and a disease course with a predominance of asthenic, dyspeptic, abdominal pain syndromes, cholestatic syndrome, hepatomegalia, obesity against the background of mild and moderate manifestations of cytolysis and mesenchymal inflammation

Spectral analysis of X-ray pulsars with the INTEGRAL observatory

We studied spectra for 34 accretion-powered X-ray and one millisecond pulsars that were within the field of view of the INTEGRAL observatory over two years (December 2002 - January 2005) of its in-orbit operation and that were detected by its instruments at a statistically significant level (>8 sigma in the energy range 18-60 keV). There are seven recently discovered objects of this class among the pulsars studied: 2RXP J130159.6-635806, IGR/AX J16320-4751, IGR J16358-4726, AX J163904-4642, IGR J16465-4507, SAX/IGR J18027-2017 and AX J1841.0-0535. We analyze the evolution of spectral parameters as a function of the intensity of the sources and compare these with the results of previous studies

Scientific ways for solving problems of organizing and planning cargo transportation to the areas of the Far North and Arctic Zones of Russia

The dominant concept of socio-economic innovation in the modern world is sustainable development, especially of the northern regions. This is explained by the following features: a) harsh weather and climatic conditions; b) the high dependence of the population’s livelihoods on the timely supply of energy, food and consumer goods; c) insufficient development of the transport and logistics system; d) high vulnerability of the environment to anthropogenic impacts; e) the need to preserve the traditional way of life of the population of the northern territories; f) the relevance of expanding production and economic activities for the development of the natural resources of the northern territories. These features have a significant impact on the structure and management of the transport and logistics system of the northern regions. The article discusses the features of planning and managing cargo transportation in the northern regions of Russia. Ensuring the reliability of cargo transportation is determined by the availability and use of initial information used in planning and organizing the work of transport enterprises. Modern information technologies (IT) improve the quality of this information and the speed of data exchange between regional transport departments and transport organizations