Enabling Exploration Through the International Docking System Standard

Human exploration missions beyond low earth orbit will likely require international cooperation in order to leverage limited resources. International standards can help enable cooperative missions by providing well understood, predefined interfaces allowing compatibility between unique spacecraft and systems. The International Space Station (ISS) partnership has developed a publically available International Docking System Standard (IDSS) that provides a solution to one of these key interfaces by defining a common docking interface. The docking interface provides a way for even dissimilar spacecraft to dock for exchange of crew and cargo, as well as enabling the assembly of large space systems. This paper provides an overview of the key attributes of the IDSS, an overview of the NASA Docking System (NDS), and the plans for updating the ISS with IDSS compatible interfaces. The NDS provides a state of the art, low impact docking system that will initially be made available to commercial crew and cargo providers. The ISS will be used to demonstrate the operational utility of the IDSS interface as a foundational technology for cooperative exploration

Using Simulated Annealing to Solve the Daily Drayage Problem with Hard Time Windows

Drayage is the stage of the intermodal transport that deals with transport of freight on trucks among the intermodal terminal, and customers and suppliers that are located in its hinterland. This work proposes an algorithm based on simulated annealing heuristics to solve the operations of drayage. This algorithm has been used to solve battery problems, demonstrating the validity and suitability of its results, which were compared with exact method

ISS - Enabling Exploration Through Docking Standards

NASA and the ISS partnership are jointly developing a key standard to enable future collaborative exploration. The IDSS is based on flight proven design while incorporating new low impact technology. Low impact technology accommodates a wide range of vehicle contact and capture conditions. This standard will get early demonstration on the ISS. Experience gained here will enable operational experience and the opportunity to refine the standard

Macroeconomic costs of the unmet burden of surgical disease in Sierra Leone: a retrospective economic analysis.

OBJECTIVES: The Lancet Commission on Global Surgery estimated that low/middle-income countries will lose an estimated cumulative loss of US$12.3 trillion from gross domestic product (GDP) due to the unmet burden of surgical disease. However, no country-specific data currently exist. We aimed to estimate the costs to the Sierra Leone economy from death and disability which may have been averted by surgical care. DESIGN: We used estimates of total, met and unmet need from two main sources-a cluster randomised, cross-sectional, countrywide survey and a retrospective, nationwide study on surgery in Sierra Leone. We calculated estimated disability-adjusted life years from morbidity and mortality for the estimated unmet burden and modelled the likely economic impact using three different methods-gross national income per capita, lifetime earnings foregone and value of a statistical life. RESULTS: In 2012, estimated, discounted lifetime losses to the Sierra Leone economy from the unmet burden of surgical disease was between US$1.1 and US$3.8 billion, depending on the economic method used. These lifetime losses equate to between 23$360 million and US$2.9 billion. CONCLUSION: There is a large economic loss from the unmet need for surgical care in Sierra Leone. There is an immediate need for massive investment to counteract ongoing economic losses

Modelling carrier decisions in an activity-based freight transportation framework: a pickup and delivery selection problem

Abstract This paper focuses on the modelling of carrier decisions within an activity-based freight transportation model. To model freight transport, the different actors who are included in the decision making process have to be represented. One of these actors is the carrier. The decisions of a carrier can be formulated as a selective pickup and delivery problem. The objective is to maximize the profit gained by selecting transport requests. This allows a better representation of the influence of carrier decisions on the logistic module within an activity-based freight transportation model. Local search operators are presented to solve the problem. Keywords: Logistic decisions, Freight transport modelling, PDSP To represent logistic decisions within an activity based freight transportation model, decisions of a carrier have to be modelled. A carrier faces the daily problem of optimally scheduling his transport orders. Each day a carrier receives transport requests from his clients, which have to be executed within a certain time period. To obtain a maximal profit the carrier has to group certain orders and create an optimal sequence of pickup and delivery tasks. The assumption mostly made is that all requests have to be fulfilled. In reality a carrier can refuse a transport order when he believes this order is not profitable. In our activity-based framework In a PDSP not all transportation requests have to be fulfilled. A carrier receives transportation requests and has to decide whether he will take the responsibility of the transport or not. Unknown requests of the future cannot be taken into account when considering the current request. Hence, the PDSP is modelled as a static planning problem. In literature this problem is not often investigated, but several variations on the problem exist. Two main bodies of routing literature are relevant for the PDSP. On the one hand Vehicle Routing Problems (VRP) with profit and on the other hand literature concerning Pickup and Delivery Problems (PDP). Th

Blueberry counteracts bv-2 microglia morphological and functional switch after lps challenge

Microglia, the innate immune cells of the CNS, respond to brain injury by activating and modifying their morphology. Our study arises from the great interest that has been focused on blueberry (BB) for the antioxidant and pharmacological properties displayed by its components. We analyzed the influence of hydroalcoholic BB extract in resting or lipopolysaccharide (LPS)-stimulated microglia BV-2 cells. BB exerted a protective effect against LPS-induced cytotoxicity, as indicated by cell viability. BB was also able to influence the actin cytoskeleton organization, to recover the control phenotype after LPS insult, and also to reduce LPS-driven migration. We evaluated the activity of Rho and Rac1 GTPases, which regulate both actin cytoskeletal organization and migratory capacity. LPS caused an increase in Rac1 activity, which was counteracted by BB extract. Furthermore, we demonstrated that, in the presence of BB, mRNA expression of pro-inflammatory cytokines IL-1β, IL-6 and TNF-α decreased, as did the immunofluorescence signal of iNOS, whereas that of Arg-1 was increased. Taken together, our results show that, during the inflammatory response, BB extract shifts the M1 polarization towards the M2 phenotype through an actin cytoskeletal rearrangement. Based on that, we might consider BB as a nutraceutical with anti-inflammatory activities

Quality of life with pharmacological treatment in patients with benign prostatic enlargement: results from the Evolution European Prospective Multicenter Multi-National Registry Study.

Item does not contain fulltext Background Lower urinary tract symptoms due to benign prostate enlargement (LUTS/BPE) can lead to significant disturbances to health-related quality of life (HRQoL) and psychological well-being. The aim of this study was to evaluate the effect of pharmacological treatment of LUTS/BPE on disease specific and generic QOL measures. Methods Evolution was a European prospective, multicenter multi-national, observational registry collecting real-life clinical data over 2 years on the management of LUTS/BPE in primary and secondary care. This study investigated disease-specific QOL using questionnaires such as IPSS Q8, BPH Impact Index (BII) and generic QOL using questionnaires like EuroQOL Five Dimension (EQ5D) which encompassed EQ5D VAS and EQ5D health index. Results The registry enrolled 1838 BPE patients and 1246 patients were evaluable at the end of 24 months. Nearly 70% of patients in the study were previously treated with medical therapy and 17% of these had already discontinued medical treatment previously for various reasons with lack of efficacy being the most common. The mean time since diagnosis of LUTS in the previously treated group was 4.7 years (0-26 years). Medical management produced statistically significant improvement in QOL (disease specific and generic) in previously untreated patients and an insignificant change in generic QOL in previously treated patients. Conclusions After 5-years from the onset of symptoms, LUTS/BPE patients previously treated with medication had significantly impaired QOL in patients in a manner comparable to other chronic diseases. Earlier intervention with minimally invasive surgical techniques (MIT) should be considered in LUTS/BPE patients that do not show a significant improvement in QOL with medical therapy

Does Scarpa's Fascia Preservation in Abdominoplasty Reduce Seroma? A Systematic Review

Abdominoplasty is a widely utilized cosmetic surgery procedure. Despite its popularity, seroma formation remains a prevalent complication. Seroma can lead to extended recovery time, increased medical appointments, and the potential for infection or the need for additional surgical revision. Preserving Scarpa's fascia may mitigate the risk of seroma in patients following abdominoplasty. The goal of this systematic review was to determine the impact of preserving Scarpa's fascia on the occurrence of seroma and total drain output following an abdominoplasty procedure. This review searched academic literature in MEDLINE (via PubMed), EMBASE (OvidSP), and the Cochrane Central Register of Controlled Trials (CENTRAL) for clinical and observational studies published in peer-reviewed journals, from March 2022 to November 2022, that evaluated the impact of preserving Scarpa's fascia on postoperative seroma and total drain output during abdominoplasty. The primary outcomes of interest were seroma and total drain output, with secondary outcomes of interest including hematoma, time to drain removal, length of hospital stay, wound dehiscence, and infection rate. The systematic review of 8 studies, involving 846 patients, found that the preservation of Scarpa's fascia during an abdominoplasty procedure was associated with decreased seroma occurrence, reduced drain output, faster drain removal, and fewer infections. However, it did not affect the incidence of hematoma, hospital stay duration, or wound dehiscence. The preservation of Scarpa's fascia during an abdominoplasty procedure should be considered as a routine practice, because it has been shown to result in reduced seroma incidence rates and faster drain removal.</p

Pickup and delivery selection problem

Abstract This paper focuses on the modelling of carrier decisions within an activity-based freight transportation model. To model freight transport, the different actors who are included in the decision making process have to be represented. One of these actors is the carrier. This paper formulates the decisions of the carrier as a selective pickup and delivery problem. To be able to better represent the influence of carrier decisions on the logistic module within an activity based freight transportation model. The objective is to maximize the profit gained, by selecting transport requests. A local search heuristic is presented to solve the problem. Keywords: Logistic decisions, Freight transport modelling, PDSP To represent logistic decisions within an activity based freight transportation model, decisions of a carrier have to be modelled. A carrier faces the daily problem of optimally scheduling his transport orders. Each day a carrier receives transport requests from his clients, which have to be executed within a certain time period. To obtain a maximal profit the carrier has to group certain orders and create an optimal sequence of pickup and delivery tasks. The assumption mostly made is that all requests have to be fulfilled. In reality a carrier can refuse a transport order, when he believes this order is not profitable. In our activity-based freight framework In a PDSP not all transportation requests have to be fulfilled. A carrier receives transportation requests during the entire day. When new requests are received a decision has to be made, whether the carrier will take the responsibility of the transport or not. Unknown requests of the future cannot be taken into account when considering the current request. Hence, the PDSP is modelled as a static planning problem. In literature this problem is not often investigated, but several variations on the problem exist. Two mai