Osteoporosis and rheumatic diseases.

Numerous rheumatic diseases, including rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, systemic lupus erythematosus, systemic sclerosis, dermatomyositis/polymyositis and vasculitis are characterized by osteoporosis and fragility fractures. Inflammatory cytokines, glucocorticoid treatment, immobilization and reduced physical activity due to painful joints and muscle weakness are considered the main risk factors that cause low body mass density values in these diseases. Emerging evidence highlights the role of inflammatory cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6, IL-7 and IL-17, in the regulation of the bone homeostasis. In fact, chronic inflammation is often characterized by an imbalance between bone formation and bone resorption with a net prevalence of osteoclastogenesis, which is an important determinant of bone loss in rheumatic diseases

KWISP: an ultra-sensitive force sensor for the Dark Energy sector

An ultra-sensitive opto-mechanical force sensor has been built and tested in the optics laboratory at INFN Trieste. Its application to experiments in the Dark Energy sector, such as those for Chameleon-type WISPs, is particularly attractive, as it enables a search for their direct coupling to matter. We present here the main characteristics and the absolute force calibration of the KWISP (Kinetic WISP detection) sensor. It is based on a thin Si3N4 micro-membrane placed inside a Fabry-Perot optical cavity. By monitoring the cavity characteristic frequencies it is possible to detect the tiny membrane displacements caused by an applied force. Far from the mechanical resonant frequency of the membrane, the measured force sensitivity is 5.0e-14 N/sqrt(Hz), corresponding to a displacement sensitivity of 2.5e-15 m/sqrt(Hz), while near resonance the sensitivity is 1.5e-14 N/sqrt(Hz), reaching the estimated thermal limit, or, in terms of displacement, 7.5e-16 N/sqrt(Hz). These displacement sensitivities are comparable to those that can be achieved by large interferometric gravitational wave detectors.Comment: 9 pages, 8 figures in colo

Digital holographic interferometry for particle detector diagnostic

In high precision scattering experiments particle tracks must often be reconstructed from a series of hits in successive detector planes. The relative distance between these planes is a critical parameter that must be monitored during operation. To address this problem we have developed a digital holographic interferometer dubbed Holographic Alignment Monitor (HAM) to be used in the MUonE project at CERN. MUonE aims at a precision measurement of the scattering angle between particles after an elastic muon-electron scattering. The HAM is designed to monitor the relative distance between position-sensitive sensor planes inside a MUonE tracking station with a resolution better than the required 10 m. The system uses a 532 nm fiber-coupled laser source both to illuminate a portion of the detector plane (object), and to provide the reference beam. A CMOS image sensor acquires the raw data, and the reconstructed holographic image of the silicon sensor being observed is computed using an algorithm containing a Fourier transform. The relative distance between silicon planes is monitored by superposing successive raw images of the same object on an initial reference one and observing the interference fringes appearing on the reconstructed holographic image. Preliminary tests have yielded a distance resolution of less than 1 m

Detecting solar chameleons through radiation pressure

Light scalar fields can drive the accelerated expansion of the universe. Hence, they are obvious dark energy candidates. To make such models compatible with tests of General Relativity in the solar system and "fifth force" searches on Earth, one needs to screen them. One possibility is the so-called "chameleon" mechanism, which renders an effective mass depending on the local matter density. If chameleon particles exist, they can be produced in the sun and detected on Earth exploiting the equivalent of a radiation pressure. Since their effective mass scales with the local matter density, chameleons can be reflected by a dense medium if their effective mass becomes greater than their total energy. Thus, under appropriate conditions, a flux of solar chameleons may be sensed by detecting the total instantaneous momentum transferred to a suitable opto-mechanical force/pressure sensor. We calculate the solar chameleon spectrum and the reach in the chameleon parameter space of an experiment using the preliminary results from a force/pressure sensor, currently under development at INFN Trieste, to be mounted in the focal plane of one of the X-Ray telescopes of the CAST experiment at CERN. We show, that such an experiment signifies a pioneering effort probing uncharted chameleon parameter space.Comment: revised versio

Magnetic Permeability of Constrained Fermionic Vacuum

We obtain using Schwinger's proper time approach the Casimir-Euler-Heisenberg effective action of fermion fluctuations for the case of an applied magnetic field. We implement here the compactification of one space dimension into a circle through anti-periodic boundary condition. Aside of higher order non-linear field effects we identify a novel contribution to the vacuum permeability. These contributions are exceedingly small for normal electromagnetism due to the smallness of the electron Compton wavelength compared to the size of the compactified dimension, if we take the latter as the typical size of laboratory cavities, but their presence is thought provoking, also considering the context of strong interactions.Comment: 8 pages, LaTex, 1 postscript figure, Phys. Let. B in press, slight text revisions, references adde

Introduction to the Special Issue on the 2009 IEEE International Solid-State Circuits Conference

The papers in this special issue are divided into the following areas: High-Performance Digital; Low-Power Digital; Memory; and Technology Directions. The IEEE International Solid-State Circuits Conference (ISSCC) was held in San Francisco, CA, February 8-12, 2009

Bone Involvement in Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by a wide variability of clinical manifestations due to the potential involvement of several tissues and internal organs, with a relapsing and remitting course. Dysregulation of innate and adaptive immune systems, due to genetic, hormonal and environmental factors, may be responsible for a broad spectrum of clinical manifestations, affecting quality of life, morbidity and mortality. Bone involvement represents one of the most common cause of morbidity and disability in SLE. Particularly, an increased incidence of osteoporosis, avascular necrosis of bone and osteomyelitis has been observed in SLE patients compared to the general population. Moreover, due to the improvement in diagnosis and therapy, the survival of SLE patient has improved, increasing long-term morbidities, including osteoporosis and related fractures. This review aims to highlight bone manifestations in SLE patients, deepening underlying etiopathogenetic mechanisms, diagnostic tools and available treatment