412 research outputs found

    1st Zonal Workshop on Policy Issues and HRD in Fisheries and Aquaculture for North Eastern States Assam, Meghalaya, Nagaland, Manipur, Mizoram, Tripura, Arunachal Pradesh and Sikkim

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    3rd Zonal Workshop on Fisheries and Aquaculture Policy: Responsible Fisheries and Sustainable Aquaculture Perspectives for West Coast States Goa, Gujarat, Karnataka, Kerala, Maharashtra, and Union Territories of Daman and Diu, Dadra & Nagar Haveli and Lakshadweep 21-23 June, 200

    2nd Zonal Workshop on Fisheries and Aquaculture Policy: Ecosystem and Livelihood Perspectives in East Coast States

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    2nd Zonal Workshop on Fisheries and Aquaculture Policy: Ecosystem and Livelihood Perspectives in East Coast States Andhra Pradesh, Andaman & Nikobar Islands, Orissa. Pondichery, Tamilnadu and West Bengal Hyderabad 22-24 March, 2007 (CIFE, MUMBAI

    Primary Bone Cancers: Latest Trends in Pathogenesis, Diagnosis and Management

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    Primary bone tumours arising from the bony tissue are further classified into three groups; bone-producing, cartilage-producing, and tumours of unknown origin. In this review article, we have analyzed the latest trends in the pathogenesis, diagnosis, and management of the key primary malignant tumours (osteosarcoma, chondrosarcoma, and Ewing sarcoma) of bony origin. The Hippo-Yap signaling pathway is a newly discovered pathogenesis for osteosarcoma, and the inhibition contributes to the treatment of the malignancy. Moreover, carbon-ion particle therapy is proven to be a remedy for radioresistant tumours. The advancement of diagnosis methods for osteosarcoma is hastened with the identification of biomarker microRNA, liquid biopsy, and ‘Omic’ technology. Chondrosarcoma has a different and tailored approach to manage patients. Due to the unknown pathogenesis, treatments are being considered holistically depending on the patients’ age, overall health, medical history, type and stages of chondrosarcoma, the severity of the carcinoma, and patients' preference or opinion on the treatment plans. It has no specific treatment, and the ideal goal is to remove the mass and reduce the likelihood of relapse.  Lastly, for Ewing sarcoma, there is a variety of new targeted therapy such as Lysine-specific demethylase-1(LSD-1), PRKCB, Poly(ADP-Ribose)polymerase1 inhibitors(PARBP1)  have been developed to treat recurrent ES, and a large dose of chemotherapy with autologous hematopoietic stem cell has been identified to cause toxicity in Ewing sarcoma. The origin of Ewing sarcoma remained unknown, but the rearrangement of the gene is thought to be the cause of tumorigenesis of Ewing sarcoma

    Exploring the Structures and Substructures of the Andromeda Satellite Dwarf Galaxies Cassiopeia III, Perseus I, and Lacerta I

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    We present results from wide-field imaging of the resolved stellar populations of the dwarf spheroidal galaxies Cassiopeia III (And XXXII) and Perseus I (And XXXIII), two satellites in the outer stellar halo of the Andromeda galaxy (M31). Our WIYN pODI photometry traces the red giant star population in each galaxy to ~2.5-3 half-light radii from the galaxy center. We use the Tip of the Red Giant Branch (TRGB) method to derive distances of (m-M)_0 = 24.62+/-0.12 mag (839 (+48,-450) kpc, or 156 (+16,-13) kpc from M31) for Cas III and 24.47+/-0.13 mag (738 (+48,-45) kpc, or 351 (+17,-16) kpc from M31) for Per I. These values are consistent within the errors with TRGB distances derived from a deeper Hubble Space Telescope study of the galaxies' inner regions. For each galaxy, we derive structural parameters, total magnitude, and central surface brightness. We also place upper limits on the ratio of neutral hydrogen gas mass to optical luminosity, confirming the gas-poor nature of both galaxies. We combine our data set with corresponding data for the M31 satellite galaxy Lacerta I (And XXXI) from earlier work, and search for substructure within the RGB star populations of Cas III, Per I, and Lac I. We find an overdense region on the west side of Lac I at a significance level of 2.5-3-sigma and a low-significance filament extending in the direction of M31. In Cas III, we identify two modestly significant overdensities near the center of the galaxy and another at two half-light radii. Per I shows no evidence for substructure in its RGB star population, which may reflect this galaxy's isolated nature.Comment: 26 pages, 15 figures, 5 tables. Accepted for publication in The Astronomical Journa

    Exploring the Structures and Substructures of the Andromeda Satellite Dwarf Galaxies Cassiopeia III, Perseus I, and Lacerta I

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    We present results from wide-field imaging of the resolved stellar populations of the dwarf spheroidal galaxies Cassiopeia III (And XXXII) and Perseus I (And XXXIII), two satellites in the outer stellar halo of the Andromeda galaxy (M31). Our WIYN pODI photometry traces the red giant star population in each galaxy to ∼2.5−3 half-light radii from the galaxy center. We use the tip of the red giant branch (TRGB) method to derive distances of (m − M) = 24.62 ± 0.12 mag (839 kpc, or 156 kpc from M31) for Cas III and 24.47 ± 0.13 mag (738 kpc, or 351 kpc from M31) for Per I. These values are consistent within the errors with TRGB distances derived from a deeper Hubble Space Telescope study of the galaxies’ inner regions. For each galaxy, we derive structural parameters, total magnitude, and central surface brightness. We also place upper limits on the ratio of neutral hydrogen gas mass to optical luminosity, confirming the gas-poor nature of both galaxies. We combine our data set with corresponding data for the M31 satellite galaxy Lacerta I (And XXXI) from earlier work and search for substructure within the RGB star populations of Cas III, Per I, and Lac I. We find an overdense region on the west side of Lac I at a significance level of 2.5σ–3σ and a low-significance filament extending in the direction of M31. In Cas III, we identify two modestly significant overdensities near the center of the galaxy and another at two half-light radii. Per I shows no evidence for substructure in its RGB star population, which may reflect this galaxy’s isolated nature. © 2023 Institute of Physics Publishing. All rights reservedThe authors wish to thank the anonymous referee for providing valuable comments and suggestions for improvements to the manuscript. We are grateful to the staff of the WIYN 3.5 m Observatory and Kitt Peak National Observatory for their help during our WIYN pODI observing runs. We also thank the staff members at WIYN, NOIRLab, and Indiana University Pervasive Technology Institute for designing and implementing the ODI Pipeline, Portal, and Archive (ODI-PPA) and assisting us with the pODI data reduction. We made use of the odi-tools python package, written by William Janesh and Owen Boberg, to produce final stacked science-ready WIYN pODI images for this study. K.L.R. and N.J.S. were supported by NSF Astronomy & Astrophysics Research grant No. AST-1615483 during part of the period when this research was carried out. Research by D.C. is supported by NSF grant AST-1814208. K.S. acknowledges support from the Natural Sciences and Engineering Research Council of Canada (NSERC). We are grateful to the Indiana University (IU) College of Arts and Sciences for funding IU's share of the WIYN 3.5 m telescope. This research has made use of the NASA/IPAC Extragalactic Database (NED), which is funded by the National Aeronautics and Space Administration and operated by the California Institute of Technology

    Gas and Star Formation in Satellites of Milky Way Analogs

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    We have imaged the entirety of eight (plus one partial) Milky Way (MW)–like satellite systems, a total of 42 (45) satellites, from the Satellites Around Galactic Analogs II catalog in both Hα and H i with the Canada–France–Hawaii Telescope and the Jansky Very Large Array. In these eight systems we have identified four cases where a satellite appears to be currently undergoing ram pressure stripping (RPS) as its H i gas collides with the circumgalactic medium (CGM) of its host. We also see a clear suppression of gas fraction (M HI/M *) with decreasing (projected) satellite–host separation—to our knowledge, the first time this has been observed in a sample of MW-like systems. Comparisons to the Auriga, A Project Of Simulating The Local Environment, and TNG50 cosmological zoom-in simulations show consistent global behavior, but they systematically underpredict gas fractions across all satellites by roughly 0.5 dex. Using a simplistic RPS model, we estimate the average peak CGM density that satellites in these systems have encountered to be logρcgm/gcm−3≈−27.3 . Furthermore, we see tentative evidence that these satellites are following a specific star formation rate to gas fraction relation that is distinct from field galaxies. Finally, we detect one new gas-rich satellite in the UGC 903 system with an optical size and surface brightness meeting the standard criteria to be considered an ultra-diffuse galaxy

    Total knee arthroplasty: good agreement of clinical severity scores between patients and consultants

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    BACKGROUND: Nearly 20,000 patients per year in the UK receive total knee arthroplasty (TKA). One of the problems faced by the health services of many developed countries is the length of time patients spend waiting for elective treatment. We therefore report the results of a study in which the Salisbury Priority Scoring System (SPSS) was used by both the surgeon and their patients to ascertain whether there were differences between the surgeon generated and patient generated Salisbury Priority Scores. METHODS: The Salisbury Priority Scoring System (SPSS) was used to assign relative priority to patients with knee osteoarthritis as part of a randomised controlled trial comparing the standard medial parapatellar approach versus the sub-vastus approach in TKA. The operating surgeons and each patient completed the SPSS at the same pre-assessment clinic. The SPSS assesses four criteria, namely progression of disease, pain or distress, disability or dependence on others, and loss of usual occupation. Crosstabs and agreement measures (Cohen's kappa) were performed. RESULTS: Overall, the four SPSS criteria showed a kappa value of 0.526, 0.796, 0.813, and 0.820, respectively, showing moderate to very good agreement between the patient and the operating consultant. Male patients showed better agreement than female patients. CONCLUSION: The Salisbury Priority Scoring System is a good means of assessing patients' needs in relation to elective surgery, with high agreement between the patient and the operating surgeon

    Cardiometabolic health across menopausal years is linked to white matter hyperintensities up to a decade later

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    Introduction: The menopause transition is associated with several cardiometabolic risk factors. Poor cardiometabolic health is further linked to microvascular brain lesions, which can be detected as white matter hyperintensities (WMHs) using T2-FLAIR magnetic resonance imaging (MRI) scans. Females show higher risk for WMHs post-menopause, but it remains unclear whether changes in cardiometabolic risk factors underlie menopause-related increase in brain pathology. Methods: In this study, we assessed whether cross-sectional measures of cardiometabolic health, including body mass index (BMI) and waist-to-hip ratio (WHR), blood lipids, blood pressure, and long-term blood glucose (HbA1c), as well as longitudinal changes in BMI and WHR, differed according to menopausal status at baseline in 9,882 UK Biobank females (age range 40–70 years, n premenopausal = 3,529, n postmenopausal = 6,353). Furthermore, we examined whether these cardiometabolic factors were associated with WMH outcomes at the follow-up assessment, on average 8.78 years after baseline. Results: Postmenopausal females showed higher levels of baseline blood lipids (HDL β = 0.14, p  Discussion: Our findings emphasise the importance of monitoring cardiometabolic risk factors in females from midlife through the menopause transition and into the postmenopausal phase, to ensure improved cerebrovascular outcomes in later years

    Formulation of plant nutrient with synbiotic enhancement

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    Oleochemical wastewater discharge from the industry into water sources is one of the main causes of water pollution. A proper treatment is required before the effluent is discharged to the environment. Since the oleochemical wastewater contains nutrients and probiotics that are good for plants, it could be used as a nutrient provider for the plants instead. Therefore, the formulation of synbiotic plant nutrients from this effluent is an effective way of using the oleochemical effluent. This study aimed to formulate the plant nutrients by using industrial wastewater, which contains the synbiotic enhancement and validating the significance of the formulated plant nutrients into three types of plants; Abelmoschus esculentus (Okra), Solanum Melongena (Brinjal), and Capsicum annuum (Chilli peppers). Synbiotic is a combination of both prebiotics and probiotics that benefit the host by stimulating the growth of a limited number of health-promoting bacteria. To formulate the plant nutrient, the wastewater was filtered using a cotton cloth before the pre-biotics solution was added. Sample A (filtered wastewater was mixed with Sample B (prebiotics solution) by different percentages, namely F1 (100%:0%), F2 (75%:25%), F3 (50%:50%), F3 (25%:75%), 0%:100% (Sample A to Sample B respectively) and lastly, 50%:50% (Sample C (unfiltered wastewater) to Sample B respectively). The height of the plant and the number of leaves are measured weekly for four months. From the data, it can be seen that F3 gave significant results for the okra plant, in which it gains the highest height of plant compared to the other two plants. On the other hand, F6 give the best results for both the brinjal and the chilli plant where their leaves grow the highest from the second until the fourth month of plant growth. Hence, this research gives an added value to the wastewater, whereas the wastewater is used as the synbiotic plant nutrient enhancer and work best for the plants
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