Enoxacin degradation by photo-Fenton process combined with a biological treatment optimization and improvement of by-products biodegradability

International audienc

Camelina a new source of healthy oil and cake: effect of variety choice and growing conditions.

Camelina [Camelina sativa (L.) Crantz] is an emerging oilseed crop able to grow in a wide range of environments either as an autumn or spring crop, with limited input requirement (Zanetti et al. 2021). Its oil has high content of PUFAs, in particular n-3 (Righini et al. 2016), with relevant food, feed and non-food uses. The full exploitation of camelina co-product (i.e. cake) is limited by the glucosinolate content and other antinutritional compounds which hampered its use in animal feeding (Colombini et al. 2013). In this context, the ARGENTO project (PRIN 2017) aims at evaluating the effect of sowing dates and environment on the productive potential and seed quality of newly released camelina lines with the intent to optimise camelina agronomic management for poultry feeding

Cryptosporidiosis after treatment with fingolimod: a case report and pharmacovigilance review

International audienceCryptosporidium sp. are common intracellular parasites responsible of severe diarrhea in T-cell-immunocompromised patients. We report the first case of a woman who contracted cryptosporidiosis after treatment with fingolimod, a drug labeled for multiple sclerosis and responsible for marked lymphopenia.Case presentation: A 60-year-old woman was admitted for abdominal pain diarrhea and fever. The patient suffered from multiple sclerosis and had been treated with fingolimod from august 2017 to september 2018 time of occurrence of the first digestive symptoms. Stool culture was negative but parasitological examination was positive for Cryptosporidium sp. Blood biological examination profound lymphopenia of 240/mm3 [17 CD4/mm3 (7%) and 32 CD8/mm3 (14%)]. Fingolimod was stopped, and the patient was put on nitazoxanide 500 mg bid for 7 days. The diarrhea resolved and no relapse was observed. Six other cases were found in the Pharmacovigilance database.Conclusion: Physicians should be aware of this association and screen for Cryptosporidium in cases of diarrhea in patients treated with fingolimod. Patients should be aware of this risk and advise to take appropriate measures to avoid such contamination

Mucormycoses pulmonaires au cours des traitements de leucémies aiguës. Analyse rétrospective d’une série de 25 patients

International audienceIntroductionIn acute leukaemia (AL), the occurrence of pulmonary mucormycosis (PM), the incidence of which is increasing, as a result of chemotherapy induced marrow aplasia, remains a life threatening complication.MethodsAnalysis of clinical, biological and thoracic CT characteristics of patients with PM developing during the treatment of AL between 2000 and 2015. Day 0 (D0) was defined as the day with first CT evidence of PM.ResultsAmong 1193 patients, 25 cases of PM were recorded during 2099 episodes of bone marrow aplasia. At time of diagnosis of PM, 24/25 patients had been neutropenic for a median of 12 days. None of the patients had diabetes mellitus. On initial CT (D0), the lesion was solitary in 20/25 cases and a reversed halo sign (RHS) was observed in 23/25 cases. From D1 to D7, D8 to D15 and after D15, RHS was seen in 100 %, 75 % and 27 % of cases, respectively. A tissue biopsy was positive in 17/18 cases. The detection of circulating Mucorales DNA in serum was positive in 23/24 patients and in 97/188 serum specimens between D-9 and D9. Bronchoalveolar lavage contributed to diagnosis in only 3/21 cases. The antifungal treatment was mainly based on liposomal amphotericin B combined with, or followed by, posaconazole. A pulmonary surgical resection was performed in 9/25 cases. At 3 months, 76 % of patients were alive and median overall survival was 14 months.ConclusionIn AL, early use of CT could improve the prognosis of PM. The presence of a RHS on CT suggests PM and is an indication for prompt antifungal treatment.IntroductionLa survenue d’une mucormycose pulmonaire (MP), dont l’incidence augmente au cours des aplasies chimio-induites des leucémies aiguës (LA), reste une complication redoutable.MéthodesAnalyse des caractéristiques clinico-biologiques et des scanners thoraciques (CT) des MP survenues au cours des traitements de LA entre 2000 et 2015. Le premier CT pathologique définissait le jour 0 (j0) de la MP.RésultatsParmi 1193 patients, 25 MP furent observées au cours de 2099 aplasies. Au diagnostic de MP, 24/25 patients étaient neutropéniques depuis une durée médiane de 12jours. Aucun patient n’était diabétique. Sur le CT de j0, l’atteinte pulmonaire était unique dans 20 cas et le signe du halo inversé (RHS) présent dans 23/25 cas. La fréquence du RHS était de 100 % entre j1 et j7 puis 75 % entre j8 et j15 et 27 % après j15. Une biopsie tissulaire était positive dans 17/18 cas. La présence d’ADN circulant de Mucorales sur sérum était observée chez 23/24 patients et dans 97/188 sérums entre j-9 et j9. Le lavage bronchoalvéolaire n’était contributif que dans 3/21 cas. Le traitement reposait majoritairement sur l’amphotéricine B liposomale combinée ou relayée par le posaconazole. Une résection pulmonaire chirurgicale était associée dans 9/25 cas. La survie à 3 mois post-MP était de 76 % et la médiane de survie de 14 mois.ConclusionAu cours des LA, le pronostic de la MP peut être amélioré par la réalisation précoce du CT permettant d’évoquer la MP en présence d’un RHS et ainsi de débuter le traitement le plus tôt possible

Ruling out nosocomial transmission of Cryptosporidium in a renal transplantation unit: case report

International audienceBackground: Cryptosporidium spp. is a ubiquitous parasite affecting humans as well as domestic and wild vertebrates, causing diarrhea in both immunocompetent and immunocompromised hosts worldwide. Its transmission occurs primarily by the fecal-oral route. In humans, C. parvum and C. hominis are the most prevalent species, whereas immunocompetent and immunocompromised individuals can also be infected by other zoonotic species. Renal transplant patients are prone to develop cryptosporidiosis, which can induce severe and life-threatening diarrhea. Case presentation: We report here a series of nearly concomitant cases of acute symptomatic cryptosporidiosis in three renal transplant patients attending the Strasbourg University Hospital Nephrology Unit. The clinical presentation was persistent diarrhea and acute renal failure. The diagnosis was confirmed by microscopic stool examination using a modified Ziehl-Neelsen staining method and species identification by molecular tools. All patients were treated with nitazoxanide and recovered from diarrhea after 14 days of therapy

Ruling out nosocomial transmission of Cryptosporidium in a renal transplantation unit: case report

International audienceBackground: Cryptosporidium spp. is a ubiquitous parasite affecting humans as well as domestic and wild vertebrates, causing diarrhea in both immunocompetent and immunocompromised hosts worldwide. Its transmission occurs primarily by the fecal-oral route. In humans, C. parvum and C. hominis are the most prevalent species, whereas immunocompetent and immunocompromised individuals can also be infected by other zoonotic species. Renal transplant patients are prone to develop cryptosporidiosis, which can induce severe and life-threatening diarrhea. Case presentation: We report here a series of nearly concomitant cases of acute symptomatic cryptosporidiosis in three renal transplant patients attending the Strasbourg University Hospital Nephrology Unit. The clinical presentation was persistent diarrhea and acute renal failure. The diagnosis was confirmed by microscopic stool examination using a modified Ziehl-Neelsen staining method and species identification by molecular tools. All patients were treated with nitazoxanide and recovered from diarrhea after 14 days of therapy