15,044 research outputs found

    A Survey of Ring Baffle Damping in Cylindrical Tanks

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    Survey of Miles method for determination of damping by ring baffles in cylindrical tank

    Supercycles for LHC commissioning and Operation

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    Alternative conceptions of comparability

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    Government Role and the Interoperability Ecosystem

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    COMPARATIVE ECOLOGY OF CALIFORNIA AND RING-BILLED GULLS (LARUS CALIFORNICUS AND L. DELAWARENSIS)

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    Analysis of Landlord/Tenant Wediation & Disparate Impact Towards Low-income People

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    This study examines the mediation as a means to settle landlord and tenant disputes and to discover if it is a just process for low-income people. Justice is defined as a process and principal by which each individual is assured the things that belong to him. One hundred subjects participated in mediation. The experimental group received training in landlord/tenant defenses prior to mediation while the control group went directly to mediation. Outcomes were measured for the experimental group, the control group, tenants going directly before the judge, and those with legal representation. These is no supporting evidence showing that justice was being served to low-income people. There was no significant difference in the outcome for tenants in the experimental and the control group.Master'sCollege of Arts and Sciences: Public AdministrationUniversity of Michiganhttp://deepblue.lib.umich.edu/bitstream/2027.42/117722/1/Baird.pd

    String Theory

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    DEE struggles to uphold her political ideals in the face of her very proper mother, THERESA, and her long-time, over-achieving friend, LEENA. She makes stands that shock and antagonize both women, including becoming a case worker for bad neighborhoods, and having lesbian romantic relationships rather than heterosexual ones. Her friend GABRIEL, a cynical gay man, is her one ally in these choices. When DEE falls in love with a man, however, these relationships are inverted, and GABRIEL feels betrayed by her cavalier attitude towards sexual orientation. GABRIEL stops speaking to DEE, and DEE and ALLEN get married. When ALLEN dies, DEE is left isolated, to explore the natures of friendship and los

    Evolution and diversity of secretome genes in the apicomplexan parasite Theileria annulata

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    <b>BACKGROUND</b>: Little is known about how apicomplexan parasites have evolved to infect different host species and cell types. Theileria annulata and Theileria parva invade and transform bovine leukocytes but each species favours a different host cell lineage. Parasite-encoded proteins secreted from the intracellular macroschizont stage within the leukocyte represent a critical interface between host and pathogen systems. Genome sequencing has revealed that several Theileria-specific gene families encoding secreted proteins are positively selected at the inter-species level, indicating diversification between the species. We extend this analysis to the intra-species level, focusing on allelic diversity of two major secretome families. These families represent a well-characterised group of genes implicated in control of the host cell phenotype and a gene family of unknown function. To gain further insight into their evolution and function, this study investigates whether representative genes of these two families are diversifying or constrained within the T. annulata population. <b>RESULTS</b>: Strong evidence is provided that the sub-telomerically encoded SVSP family and the host-nucleus targeted TashAT family have evolved under contrasting pressures within natural T. annulata populations. SVSP genes were found to possess atypical codon usage and be evolving neutrally, with high levels of nucleotide substitutions and multiple indels. No evidence of geographical sub-structuring of allelic sequences was found. In contrast, TashAT family genes, implicated in control of host cell gene expression, are strongly conserved at the protein level and geographically sub-structured allelic sequences were identified among Tunisian and Turkish isolates. Although different copy numbers of DNA binding motifs were identified in alleles of TashAT proteins, motif periodicity was strongly maintained, implying conserved functional activity of these sites. <b>CONCLUSIONS</b>: This analysis provides evidence that two distinct secretome genes families have evolved under contrasting selective pressures. The data supports current hypotheses regarding the biological role of TashAT family proteins in the management of host cell phenotype that may have evolved to allow adaptation of T. annulata to a specific host cell lineage. We provide new evidence of extensive allelic diversity in representative members of the enigmatic SVSP gene family, which supports a putative role for the encoded products in subversion of the host immune response
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