環境分析・実験系廃液処理だより《センターより》

textapplication/pdfdepartmental bulletin pape

Investigation on recognition of concept of plastics among students in faculty of education

本学の教育学部に所属する１年生を主な対象として、プラスチック概念に関する認識調査を行った。得られた調査結果を分析して現状をまとめた。「軽い」、「丈夫」、「加工しやすい」などのプラスチックに共通する性質やプラスチックの原料が石油であることを認識しているものの、プラスチックがどのような成分から構成されているか、そして、石油からどのようにプラスチックが作られているのかについての知識の定着がなされていない。また、プラスチックにはいくつかの種類が存在することを多くの学生が認識しているものの、それらの個別の特性については把握していないことも判明した。以上のことから、教育学部学生において当該概念の十分な認識には至っていないと結論づけられた

Observation of B+→pΛ̅γ

journal articl

急速通電加熱熱間成形ダイクエンチ法の適用における冶金学的留意点の明確化

application/pdf高強度の鋼板成形部品が得られる熱間プレス・ダイクエンチ工程の導入が自動車産業界において増加し始めており、本工程での素材加熱に対する通電加熱の応用に高い関心が集まっている。本研究では、通電加熱応用に際しての注意すべき冶金学的問題点について、実用鋼板を用いた実験により調査し、これを明らかにした。本調査によって明らかとなった通電加熱応用に際しての注意点は、これを有効に活かすべく、国内外の関連学会にて公表した。In the circumstances that a use of the hot-stamping process combined with press-quenching which can produce high-strength steel sheet parts has been increasing, application of a resistance heating method to the process draw much attention in automotive industry. In this study, metallurgical points to pay attention to on the application were experimentally investigated using a practically used hot-stamping steel sheet as an experimental material. The points cleared up through the investigation were published in relevant academic conferences at home and abroad to turn to practical use.平成21~23年度科学研究費補助金(基盤研究(C))研究成果報告書21560120research repor

紛争の構図と政治学的分析視角 ： シリーズ 紛争処理過程の政治学的分析(2)

2008-06-30河野正憲教授退職記念論文集departmental bulletin pape

A Proteomics Platform Combining Depletion, Multi-lectin Affinity Chromatography (M-LAC), and Isoelectric Focusing to Study the Breast Cancer Proteome

The discovery of breast cancer associated plasma/serum biomarkers is important for early diagnosis, disease mechanism elucidation, and determination of treatment strategy for the disease. In this study of serum samples, a multidimensional fractionation platform combined with mass spectrometric analysis were used to achieve the identification of medium to lower abundance proteins, as well as to simultaneously detect glycan and abundance changes. Immuno-affinity depletion and multi-lectin chromatography (M-LAC) were integrated into an automated HPLC platform to remove high abundance protein and fractionate glycoproteins. The collected glycoproteomes were then subjected to isoelectric focusing (IEF) separation by a digital ProteomeChip (dPC), followed by in-gel digestion and LC–MS analysis using an Orbitrap mass spectrometer. As a result, the total number of identified proteins increased significantly when the IEF fractionation step was included as part of the platform. Relevant proteins with biological and disease significance were observed and the dynamic range of the serum proteome measurement was extended. In addition, potential glycan changes were indicated by comparing proteins in control and cancer samples in terms of their affinity to the multi-lectin column (M-LAC) and the pI profiles in IEF separation. In conclusion, a proteomics platform including high abundance protein depletion, lectin affinity fractionation, IEF separation, and LC–MS analysis has been applied to discover breast cancer-associated proteins. The following candidates, thrombospondin-1 and 5, alpha-1B-glycoprotein, serum amyloid P-component, and tenascin-X, were selected as promising examples of the use of this platform. They show potential abundance and glycan changes and will be further investigated in future studies

Meta-analyses of association of the <i>LCE3C_LCE3B</i> deletion with RA in the Spanish, Chinese and Dutch cohort.

<p>Number of controls in the Spanish, Chinese and Dutch studies is 978, 681 and 779 respectively. The number of controls in the meta-analysis is 2438. <i>LCE3C_LCE3B</i> deletion: deletion of the <i>LCE3B</i> and <i>LCE3C</i> gene; del: deletion; CCP−: patients negative for anti cyclic citrullinated peptide; CCP+: patients positive for anti-cyclic citrullinated peptide; RF−: patients negative for rheumatoid factor; RF+ patients positive for rheumatoid factor. OR: odds ratio; L95: left border 95% confidence interval. R95: right border 95% confidence interval. I² (p): measure for heterogeneity and p-value of the chi-square test for heterogeneity.</p

Demographics of the rheumatoid arthritis cohort.

<p>Numbers are depicted as n(%) or mean ± standard deviation. Data available for ^#686, ^##717, ^###952, ^####451 patients. RA: rheumatoid arthritis; CCP: anti-cyclic citrullinated peptide; RF: rheumatoid factor.</p

A molecular signature of epithelial host defense: comparative gene expression analysis of cultured bronchial epithelial cells and keratinocytes-1

<p><b>Copyright information:</b></p><p>Taken from "A molecular signature of epithelial host defense: comparative gene expression analysis of cultured bronchial epithelial cells and keratinocytes"</p><p>BMC Genomics 2006;7():9-9.</p><p>Published online 18 Jan 2006</p><p>PMCID:PMC1382211.</p><p>Copyright © 2006 Vos et al; licensee BioMed Central Ltd.</p>TPE values of the gene are listed for both PBEC and KC after cytokine exposure. Tags for which no TPE value could be calculated because of absence of the tag in the particular library are indicated by "not available" (N/A). The predicted preferential expression could be verified for all genes. The expression of six of these genes seems to be selective for epithelial cells only. Whereas SPRR1B is preferentially expressed by epithelial cells, moderate to low levels of expression were also detected in other cell types as well. SPRR2A is preferentially expressed by PBEC only. No tags for SPRR2A were found in the KC libraries after TNFα exposure whereas expression for CALML5 was observed by RT-PCR in both PBEC and KC, while no tags for this gene were found in PBEC libraries