Spin observables in deuteron–proton radiative capture at intermediate energies

A radiative deuteron–proton capture experiment was carried out at KVI using polarized-deuteron beams at incident energies of 55, 66.5, and 90 MeV/nucleon. Vector and tensor-analyzing powers were obtained for a large angular range. The results are interpreted with the help of Faddeev calculations, which are based on modern two- and three-nucleon potentials. Our data are described well by the calculations, and disagree significantly with the observed tensor anomaly at RCNP.journal articl

クントゥル・ワシ神殿の構造

研究課題番号：14101003 研究課題名：先史アンデス社会における文明の形成プロセスの解明textapplication/pdfresearch repor

Combination Therapy of Interventional Radiology and Surgery for Infarction of the Small Intestine Caused by Portal Vein and Mesenteric Vein Thrombosis: A Patient Report

journal articl

Observation of mixing-induced CP violation in the neutral B meson system

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Meteorogical Observations in Hunyu Experimental Forest of Utsunomiyia University (1998)

text紀要論文 / Departmental Bulletin Paperdepartmental bulletin pape

Development of molecular probes for intracellular hydrogen peroxide imaging

本総説は過酸化水素の可視化のための分子プローブの開発についてまとめている。最近の研究から、細胞の移動、増殖、分化などの様々な細胞の機能に内在的に生産された過酸化水素が不可欠な役割を果たすことが明らかとされている。しかしながら、過酸化水素の果たす役割をより正確に理解するには、細胞内の過酸化水素を高感度で正確に検出することのできるプローブ分子を開発する必要がある。過酸化水素蛍光プローブを用いた検出手法は細胞や組織内の過酸化水素の生成や位置をモニタリングする有力な手法の1つである。そのため、過酸化水素用の蛍光プローブの数は近年かなり増加した。この総説の目的は、過酸化水素の生物学的役割と過酸化水素の比色定量、蛍光定量のためのプローブ分子の開発と発展の歴史を概観することにある。The review focuses on development of molecular probes for the visualization of hydrogen peroxide. Recent researches have revealed that endogenously produced hydrogen peroxide plays essential roles in various cellular functions including cell migration, proliferation, and differentiation. It is desirable to develop sensitive and specific molecular probes for intracellular hydrogen peroxide probes for our understanding of the more precise roles played by hydrogen peroxide. The detection method base on hydrogen peroxide-specific fluorescent probes is one of powerful modalities for monitoring the formation and localization of hydrogen peroxide in cells and organisms. As a consequence, the number of fluorescent probes for hydrogen peroxide has increased substantially in recent years. The aim of this review is an overview of the biological roles of hydrogen peroxide and the historical developments and applications of molecular probes for the colorimetric and fluorescent detection of hydrogen peroxide.application/pdfdepartmental bulletin pape

Self-Thinning Boundary Line and Dynamic Thinning Line in Prince Rupprecht's Larch (Larix principis-rupprechtii Mayr) Stands

1997-12The self-thining boundary line and the dynamic thinning line were determined to investigate the characteristics of self-thinning in Prince Rupprecht’s larch (Larix principis-rupprechtii Mayr) stands. The self-thinning boundary line for 56 sample stands showed a slope of – 1.75, which was significantly steeper than the conventional value of – 3/2. The mean stem volume (ν) – density (ρ) trajectories examined in three sample stands gradually approached their own dynamic thinning lines, which have respective slopes of －1.74, －1,75 and －1.70 with increasing stand age. The ν- ρ trajectories were well fitted with Hagihara’s model, so that this model was considered to be suitable for describing the ν-ρ trajectory during the course of self-thinning. The dynamic thinning lines lay below the self-thinning boundary line and they were almost parallel to each other.落葉松林の自己間引きのバウンダリーラインとダイナミックラインを、それぞれ56林分と3林分で調べた。56林分で調べた落葉松林の自己間引きのバウンダリーラインの傾きは－1.75であった。この値は一般的に報告されている－3/2より有意に小さかった。林分の成育につれて、平均材積と密度の軌跡は、徐々にそれぞれ－1.74、－1.75、－1.70の傾きを持つ自己間引きのダイナミックラインに近づいた。これらの軌跡は萩原のモデルで良く近似され、このモデルは自己間引きのダイナミックラインは自己間引きのバウンダリーラインより下に位置し、お互いに平行関係にあった。農林水産研究情報センターで作成したPDFファイルを使用している。departmental bulletin pape

Development of metal-complex catalysts inspired by the action mechanism of metalloenzymes

芳香環を一段階で水酸化する反応は製薬などの多様な化学プロセスにおいて重要,且つ,望ましい化学反応である.本反応は困難ではあるが,チトクロムP450やプテリン依存性酵素やチロシナーゼのような酸素活性化金属酵素によって達成されている.プテリン依存性酵素では,還元型プテリンの力を借り,単核非ヘム鉄中心で分子状酸素が活性化され,鉄2価アルキルペルオキソ種が生成する.鉄2価アルキルペルオキソ種の酸素-酸素結合がイオン的に開裂し,鉄4価オキソ種が生成する.この高原子価鉄オキソ種はその求電子性のために芳香環水酸化反応を達成することができる.この見事な化学反応機構は,高原子価鉄オキソ種を介した芳香環の直接水酸化を触媒的に行う,芳香環水酸化酵素の機能モデル錯体の創成へと多くの研究者を駆り立ててきた.活性種は鉄錯体と過酸化水素との反応によって発生させることができるが,多くの場合,外部基質が無選択的に酸化されたり,鉄錯体自身が分解されたりする.この様に,鉄3価ヒドロペルオキソ種の酸素-酸素結合はラジカル的ではなく,イオン的に開裂しなくてはならない.本論文では,過酸化水素を酸化剤とし,芳香環の直接水酸化反応を触媒する単核非ヘム鉄錯体の開発の最近の進展を総括する.Direct aromatic ring hydroxylation is an important and desirable chemical reaction in various chemical processes such as drug synthesis. This reaction is hard to be achieved, but is carried out by some dioxygen-activating metalloenzymes such as cytochrome P450, pterin-dependent dioxygenases, and tyrosinase. In the pterin-dependent dioxygenases, dioxygen is activated at the mononuclear nonheme iron(II) ion in cooperation with reduced pterin cofactor to generate an iron(II)-alkylperoxo species. The heterolysis of the O−O bond in the iron(II)-alkylperoxo species results in the generation of an iron(IV)-oxo species. The high-valent iron oxo species is capable of performing aromatic ring hydroxylation due to its electrophilicity. This elegant chemical mechanism has stimulated many researchers to develop functional model complexes for aromatic ring hydroxylases, which can catalytically perform the direct aromatic ring hydroxylation reaction via a hypervalent iron-oxo species. The active species can be generated through the reaction of iron complexes with hydrogen peroxide, but often produce undesirable hydroxyl radicals via homolytic cleavage of the O−O bond in iron(III)-hydroperoxo species, which results in unselective oxidation of substrates and/or decomposition of the iron complex itself. Thus, the O−O bond in the iron(III)-hydroperoxo species must be cleaved heterolytically, but not homolytically. In this paper, recent progress is reviewed in the development of mononuclear nonheme iron complexes that catalyze direct hydroxylation of aromatic rings using hydrogen peroxide as an oxidant.application/pdfdepartmental bulletin pape