대사증후군 위험요인에 대한 유전체, 마이크로바이옴, 환경인자의 영향

학위논문(석사)--서울대학교 대학원 :보건대학원 보건학과,2019. 8. 원성호.Metabolic syndrome is a well known risk factor for cardiovascular disease. Therefore better understanding of each component of metabolic syndrome is required. Metabolic syndrome results from genetics, environmental factors, and the interaction between them. Many recent studies have shown that microbiome composition also affects the development of metabolic syndrome. In this study, the main goal is to identify and compare the associations of host genetic, metagenome, and environmental factors on metabolic syndrome components. Each data source was prepared through quality control and imputation process considering characteristics of each data. The effect of each data source was evaluated using the heritability estimation approach and the prediction model separately. In heritability estimation, we found that 5 of the 11 phenotypes are significantly associated with metagenome-wide similarity. Metagenome source also provided a more accurate estimation than the genetics at the same sample size. In the prediction model, the contribution of each source to the prediction accuracy varied for each phenotype. Through various methods, we grasped the influence of host genetic, metagenome and environmental factors on each metabolic component and quantified the relative importance of each data source. If the sample size is increased and methods are developed considering the characteristics of each data source in a further study, the effect of each data will be confirmed more accurately.1.INTRODUCTION 5 2.METHODS 9 -Data description 9 -Genome 9 -Microbiome 9 -Environment 10 -Metabolic profile 11 -Statistical analysis 11 -Heritability estimation 11 -Prediction model 13 3.RESULTS 15 -Variance estimation 16 -Prediction accuracy 19 4.DISCUSSION 23 5.REFERENCE 26Maste

Inhibitory effects on Myc-Max-DNA complex formation and regulation of c-myc gene expression in cancer cells by fatty acids from ulmi cortex

Thesis (master`s)--서울대학교 대학원 :화학부 생화학전공,2004.Maste

PMMAPC 블렌드의 동력학에 관한 고체상 2H NMR 연구

Maste

Effect of alcohol drinking on mortality. : 코호트연구

보건학과/석사[한글] 이 연구에서는 음주가 사망에 미치는 영향을 알아 보기 위하여 55세 이상의 강화도 지역주민 6,382명을 대상으로 6년간 추적한 코호트연구를 통해 음주여부와 이와 관련된 위험요인 및 음주와 사망 중 특히, 암과 뇌졸중으로 인한 사망과의 관계를 보았다. 음주자는 비음주자에 비해 자신의 건강상태가 좋다고 생각하는 사람이 많았고 음식도 짜게 먹는다고 하였으며 흡연자와 고혈압이 있는 경우가 많았다. 여성의 경우에는 비음주자에 비해 음주자가 자연유산이나 사산의 경험이 더 많았다. 남자의 경우 전체사망률이 비음주군에 비해 과음주(≥30㎖/day)에서 유의하게 높았다.(RR=1.3, 95% CI: 1.1-1.7). 암과 뇌졸중 사망에 있어서 남자의 경우 악성신생물로 인한 사망률은 과음주군에서 비음주군에 비해 1.3배 높았으나 유의하지 않은데 비해 뇌종중의 경우에는 과음주군의 사망률이 통계학적으로 유의하게 높았다.(RR=2.0, 95% CI: 1.0-4.1). 이상의 결과를 볼 때 비음주자에 비해 음주자는 흡연, 고혈압 등의 위험요인을 더 많이 갖고 있으며 과량의 음주는 고혈압에 의한 뇌졸중 사망률을 증가시키는 것으로 추정되므로 과음을 삼가는 것이 전체사망 중 특히 뇌졸중으로 인한 사망을 감소시키는데 중요할 것으로 생각된다. [영문] The effect of alcohol drinking on 6-year mortality was studied in a sample of 6,382 men and women aged 55 years and older residing in Kangwha island as of February 28, 1985. Drinkers, in comparison with non-drinkers, considered their health status to be good, consumed more salty foods, had higher blood pressure, and tended to be smokers. Among men, total mortality was higher in heavy drinkers(≥30 ml/day) compared to non-drinkers (PR=1.3, 95% CI:1.1-1.7). Cancer mortality was not significantly associated with alcohol consumption levels whereas the risk of deaths caused by stroke in male heavy drinkers was higher than that of non-drinkers (PR=2.0, 95% CI: 1.0-4.1). No significant association was noted among light or moderated drinkers. It is important to abstain from heavy drinking in order to prevent deaths especially those caused by stroke, since heavy alcohol intake appears to act as a risk factor in the development of stroke through its effecting blood pressure.restrictio