16 research outputs found
건κ°ν 리λμμ μν μ μ§νλ ¨μΌλ‘μμ μ½μΉ: μλ³μ±λ¬Έκ΅νλ₯Ό μ€μ¬μΌλ‘
(The) effect of propofol on cytokine release in patients who undergo colo-rectal cancer surgery
μκ³Όνμ¬μ
λ¨/μμ¬[νκΈ]λͺ©μ : Propofolμ΄ μμ μ€ cytokine λ°μμ λν μν₯μ μΉ μΌμ¦ λλ μΈν¬ λ§€κ° λ©΄μ κΈ°λ₯ νμ§μ λν μ°κ΅¬μ λ° μΌμ¦ λλ μΈν¬ λ§€κ° λ©΄μ κΈ°λ₯ μ΅μ μ λν μ°κ΅¬ λ³΄κ³ κ° μλ€. μμ μ€ cytokine λ°μμ λν propofolμ μν₯μ μμ보기 μν΄ λ³Έ μ μλ interleukin-10κ³Ό interleukin-12λ₯Ό μΈ‘μ νμ¬ enflurane ν‘μ
λ§μ·¨μ μ λΉκ΅νκ³ μ νμλ€.
μ¬λ£ λ° λ°©λ²: λ³Έ μ°κ΅¬λ λ―Έκ΅ λ§μ·¨κ³Όνν μ 체 λ±κΈ(American Society of Anesthesiologists:ASA) I λλ IIμ ν΄λΉλλ λμ₯ μ§μ₯μ μμ μ λ°λ 30 λͺ
νμλ₯Ό λμμΌλ‘ propofolκ΅°κ³Ό enfluraneκ΅°μΌλ‘ 15 λͺ
μ© λ¬΄μμλ‘ λλμλ€. Propofol κ΅°μ μ μ£Όλ‘ λ§μ·¨ μ λ λ° μ μ§λ₯Ό νμλ€. μ ν ν΅μ¦ κ΄λ¦¬λ ν볡μ€μμ λΆνλμΌλ‘ pethidine HCl 25 mgμ 1 ν λ΄μ§ 2 ν μ λ ν¬μ¬νμ¬ visual analogue scale μ μ 5 μ΄νλ‘ ν΅μ¦ μ‘°μ ν ν΅μ¦ μκ° μ‘°μ μ₯μΉ(patient controlled analgesia device: PCA)λ₯Ό μ°κ²°νμλ€. Enflurane κ΅°μ thiopentalλ‘ λ§μ·¨ μ λνμκ³ λ§μ·¨ μ μ§λ enflurane ν‘μ
μΌλ‘ μ‘°μ νμλ€. μ ν ν΅μ¦κ΄λ¦¬λ propofol κ΅°κ³Ό λμΌνκ² νμλ€. μ±νμ μμ μ₯ λμ°© μ, νΌλΆ μ κ° 1μκ° ν, 4 μκ° ν, 8 μκ° ν, 24 μκ° νμ μννμλ€. μ±ν λΉμ νμμ νμ, λ§₯λ°μλ₯Ό μΈ‘μ νμκ³ , μμ μ€ ν¬μ¬λ μμ‘ λ° μνλ, μΆνλ, λ§μ·¨ μκ°, μμ μκ°μ κΈ°λ‘νμλ€.
κ²°κ³Ό: μμ μμ 1 μκ° ν μΈ‘μ ν interleukin-10μ μκ΅° λͺ¨λμμ μμ μ λ³΄λ€ μλ―Έ μκ² μμΉ ν λ€μ ν볡λμκ³ , μκ΅° κ°μ μλ―Έ μλ μ°¨μ΄λ 보μ΄μ§ μμλ€. Interleukin-12λ μ κ΅° λͺ¨λ κ° κ΅° λ΄μμλ μλ―Έ μλ λ³νκ° μμκ³ μ κ΅°κ° λΉκ΅μμλ μλ―Έ μλ μ°¨μ΄λ₯Ό 보μ΄μ§ μμλ€.
κ²°λ‘ : μμ κ³Ό μ°κ΄λ λ° μΌμ¦μ± cytokine λ°μμ νμΈν μ μμμΌλ propofol μ μ£Όλ§μ·¨κ° enflurane ν‘μ
λ§μ·¨μ λΉν΄ μΉ λλ λ° μΌμ¦ λ°μ μ€ μ΄λ ν μͺ½μΌλ‘ λ°μμ λ ν₯μμν¨λ€λ κΈ°μ‘΄μ μ£Όμ₯λ€μ μ§μ§νμ§λ λͺ» νμλ€.
ν΅μ¬λλ λ§: propofol, μΉμΌμ¦ λ°μ, λ°μΌμ¦ λ°μ, cytokine, λμ₯-μ§μ₯μ μμ
[μλ¬Έ]Purpose: The role of propofol on the inflammatory cytokine response during the surgery has been contradictory. This study was conducted to evaluate the effect of propofol on cytokine responses compared to that of enflurane. Pro- and anti-inflammatory cytokines, interleukin (IL)-10 and IL-12, were measured.
Methods: Total 30 patients, who underwent colo-rectal cancer surgery, were randomly assigned into two groups in double-blind fashion. One group (n = 15) was anesthetized with enflurane vapor anesthetic, whereas the other group (n = 15) with propofol intravenous infusion. At predetermined time intervals, the changes of IL-10 and IL-12 were measured. In addition, vital signs, amount of fluid infused during operation, estimated blood loss, total amount of pethidine given within 24 hours after operation were also measured.
Results: There were no statistically significant differences in the changes of IL-10 and IL-12 concentrations at all intervals when compared between two groups, although the IL-10 was significantly increased at 1 hour after incision within each group. No other measured variables showed any meaningful differences.
Conclusion: This study has demonstrated that the propofol anesthesia did not prevent the surgical stress provoked cytokine responses.
Key Words:
Cytokine, pro-inflammatory, anti-inflammatory, propofol, surgeryope
Improved stability of extracorporeal perfusion system using Bio-pump and prolongation of pig liver perfusion time by gabexate mesilate continuous infusion
νμλ
Όλ¬Έ(λ°μ¬)--μμΈλνκ΅ λνμ :μνκ³Ό μΈκ³Όνμ 곡,2000.Docto
(A)Cross-national comparative study on the major values and virtues of moral and ethics education
νμλ
Όλ¬Έ(λ°μ¬)--μμΈλνκ΅ λνμ :κ΅λ―Όμ€λ¦¬κ΅μ‘κ³Ό,2004.Docto