Association of dietary patterns with metabolic syndrome among residents in Xiamen city

目的探讨福建省厦门市居民膳食模式与代谢综合征(MS)及其组分之间关系。方法本研究于2015年12月-2016年9月采用多阶段分层整群随机抽样的方; 法,对厦门市2; 508名≥18岁居民进行膳食调查、体格测量及生化指标检测,采用因子分析法确定膳食模式,分析不同膳食模式与MS及其组分的关系。结果因子分析结果得出; 调味品模式、沿海特色模式、奶类少油模式、水果蔬菜模式4种膳食模式;多因素logistic回归分析显示,控制混杂因素后,调味品模式是MS组分高血压; 的危险因素(最高三分位数相对于最低三分位数的比值,即T3:T1OR=1.60,95%CI=1.19~2.15),奶类少油模式是MS(T3:T1; OR=0.47,95%CI=0.30~0.75)和高血压(T3:T1; OR=0.49,95%CI=0.36~0.65)的保护因素;未发现沿海特色模式和水果蔬菜模式与MS及其组分之间存在统计学关联。结论膳食模式与MS; 及其组分血压发现水平存在一定关联,减少食用盐、食用油的摄入、增加奶类的摄入,对预防MS及其组分血压水平有重要意义。Objective To explore the relationship between dietary pattern and; metabolic syndrome (MS) in residents of Xiamen city. Methods Using; multistage stratified cluster random sampling,2 508 residents were; selected to receive a dietary survey and anthropometric and biochemical; measures from December 2015 to September 2016.Factor analysis was used; to identify food patterns based on the dietary survey.Chi-square test; and logistic regression were used to analyze the relationship between; food patterns and MS and its components. Results Four dietary patterns; were identified,including condiment,sea food,more milk and less oil,and; fruits and vegetables pattern.After adjusting for potential confounding; factors,the upper tertile (T3) of the condiment pattern was associated; with higher risks of hypertension compared with the lowest tertile; (T1)(T3:T1 odds ratio[OR]=1.60,95% confidence; interval[95%CI]=1.19-2.15).T3 of the more milk and less oil pattern was; associated with lower risks of MS and hypertension compared with the; T1(T3:T1 OR=0.47,95%CI=0.30-0.75;T3:T1 OR=0.49,95%CI=0.36-0.65).No; correlation was found between the sea food pattern,fruits and vegetables; pattern with MS and its components. Conclusion Dietary patterns are; associated with MS and blood pressure levels.Limiting intake of table; salt and oil,increasing intake of milk may play important roles in the; prevention of MS and high blood pressure

厦门市居民高尿酸血症与膳食嘌呤摄入的相关性研究

目的探讨厦门市居民高尿酸血症与膳食嘌呤摄入之间的关系。方法于2016年4～8月,多阶段分层整群随机抽取厦门市18岁以上的常住居民,对其进行健康问卷调查、膳食调查、体格检查和实验室检查。结果本次共调查2827人,平均年龄(36.9±14.5)岁,男性占43.1%。高尿酸血症患病率为27.2%,男性(36.1%)患病率高于女性(20.5%),各年龄组患病率逐渐升高。调查人群平均每标准人日摄入嘌呤总量为(448.82±4.40)mg,动物性食物中畜禽肉类食物嘌呤贡献率最高(30.3%),鱼虾蟹贝类次之(17.9%);植物性食物中,米及其制品的嘌呤贡献率最高(26.3%),蔬菜类次之(9.1%),豆类、菌藻类、坚果和水果的贡献率分别为8.8%、4.8%、0.8%和0.6%。男性膳食嘌呤摄入量大于女性(P<0.001)。男性人群中,饮酒、高BMI、高血压、高次黄嘌呤摄入是高尿酸血症患病的危险因素。女性中高年龄组、高BMI、高血压是高尿酸血症患病的危险因素。结论厦门市居民高尿酸血症患病率较高,膳食嘌呤摄入较高,男女性HUA患病的危险因素不同,针对不同人群应给予不同的干预方案。[营养学报,2019,41(1):20-23,29

南靖县居民营养与健康状况监测分析

目的了解南靖县居民营养与健康状况。方法通过多阶段分层整群抽样方法,抽取南靖县6个村（居）委会共450户家庭,对全家成员进行问卷调查、医学体检、实验室检测和膳食调查。结果被调查人群谷薯类食物摄入量适宜,水果、奶类、豆类、坚果食物摄入量偏低,禽畜肉类、食用油、盐摄入量偏高;宏量营养素供能比例较合理,钠摄入偏高,能量、维生素A、硫胺素、核黄素、维生素C、钙、锌摄入不足状况严重。被调查人群超重率23.8%,肥胖率7.6%,高血压患病率19.3%,贫血患病率7.6%,空腹血糖受损率5.7%,考虑糖尿病率3.5%,血脂异常率高达66.5%。结论南靖县居民的膳食结构不够合理、油盐摄入偏高、部分微量营养素摄入不足,超重率、肥胖率、慢性病患病率已较严重

Electric-field-induced selective catalysis of single-molecule reaction

随着单分子电学检测技术的迅速发展，分子电子学的研究不再局限于分子电子学器件的构筑及其电学性质的测量，而且扩展到单分子尺度化学反应过程的探索。然而目前相关的研究仍然局限于理论计算方面，在单分子尺度上实时监测和调控化学反应的活性和选择性是化学领域的长期目标和挑战。针对这一挑战，洪文晶教授课题组与程俊教授课题组合作，自主研发了精密科学仪器，将单个有机分子定向连接在两个末端尺寸为原子级的电极之间，解决了化学反应中分子取向控制的问题.理论计算结果证实了定向电场可以有效地稳定化学反应的过渡态，从而降低反应能垒。该研究工作在化学化工学院洪文晶教授、程俊教授、能源材料化学协同创新中心（iChEM）刘俊扬副研究员的共同指导下完成，由硕士研究生黄晓艳、iChEM博士研究生唐淳、博士研究生李洁琼以及兰州大学的陈力川博士作为共同第一作者，化学化工学院师佳副教授、陈招斌高级工程师、夏海平教授和田中群教授，萨本栋微纳研究院杨扬副教授、环境与生态学院白敏冬教授以及兰州大学张浩力教授参与了研究工作的讨论并给予指导，博士后乐家波、博士研究生郑珏婷、张佩（已毕业）、李瑞豪、李晓慧也参与了研究工作。Oriented external electric fields (OEEFs) offer a unique chance to tune catalytic selectivity by orienting the alignment of the electric field along the axis of the activated bond for a specific chemical reaction; however, they remain a key experimental challenge. Here, we experimentally and theoretically investigated the OEEF-induced selective catalysis in a two-step cascade reaction of the Diels-Alder addition followed by an aromatization process. Characterized by the mechanically controllable break junction (MCBJ) technique in the nanogap and confirmed by nuclear magnetic resonance (NMR) in bottles, OEEFs are found to selectively catalyze the aromatization reaction by one order of magnitude owing to the alignment of the electric field on the reaction axis. Meanwhile, the Diels-Alder reaction remained unchanged since its reaction axis is orthogonal to the electric fields. This orientation-selective catalytic effect of OEEFs reveals that chemical reactions can be selectively manipulated through the elegant alignment between the electric fields and the reaction axis.This work was supported by the National Key R&D Program of China (2017YFA0204902), the National Natural Science Foundation of China (21722305, 21703188, 21673195, 21621091, 51733004, 51525303, and 91745103), the China Postdoctoral Science Foundation (2017M622060), and the Young Thousand Talents Project of China. 该工作得到国家自然科学基金委（21722305、21703188、21673195、51733004、51525303、91745103），国家重点研发计划课题（2017YFA0204902），中国博士后面上基金（2017M622060）的资助，以及固体表面物理化学国家重点实验室、醇醚酯化工清洁生产国家工程实验室、能源材料化学协同创新中心的支持

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies