282 research outputs found

    Involvement of Abnormal MicroRNA Expression in the Mechanism of Drug Resistance with Acute Myeloid Leukemia

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    目的:分析miRNA-98的表达异常在急性髓系白血病化疗耐药机制的作用,通过靶向过表达miRNA-98的表达水平探讨以miRNA-98为靶点增加化疗药物敏感性的可能性并分析其可能作用的机制。评价异常表达的血清miRNA-155是否可作为急性髓系白血病的预后标志。 方法:离体实验中,采用qRT-PCR方法检测K562和其耐药株K562/A02中miR-98、E2F1基因表达情况。通过瞬时转染miR-98mimic处理耐药细胞K562/A0248h后,通过qRT-PCR法检测miR-98表达情况;通过qRT-PCR和Westernblot方法检测E2F1表达的变化,应用CCK8方法检测耐药细胞的...Objective:To analyze the effects of miRNA-98 on drug resistance in chemotherapy of acute myeloid leukemia(AML).To explore the possibility and mechanism of increasing the sensitivity of chemotherapeutic drugs by using miRNA-98 as a target and its overexpression. To evaluate whether the abnormal expression of serum miRNA-155 can be used as the prognostic marker in AML. Methods:In vitro...学位:医学硕士院系专业:医学院_内科学学号:2452013115346

    中国对外援助能够促进受援国的贸易发展吗?——基于非洲16个受援国面板数据的实证研究

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    作为一个新兴援助国,中国对外援助及其援助模式的有效性备受关注。在系统梳理中国对外援助与受援国对外贸易之间理论机制的基础上,采用非洲16个受援国2002~2011年的面板数据,首次研究了中国对外援助与受援国对外贸易之间的关系,研究发现:中国对外援助能够显著增加受援国对中国的出口总额,但其影响存在倒“U”型“门槛效应”;会降低受援国的出口多样化水平;与援助相比,受援国的经济发展水平、人口、自然资源是其对外贸易发展的主要决定因素,而且人均收入水平与出口多样化之间呈现明显的倒“U”型关系。本文系2016年度国家社科基金重大项目“中国国际援助和开发合作体系创新研究”(项目批准号16ZDA037)、2015年度国家社科基金重大项目:“中国对非洲关系的国际战略研究”(项目批准号15ZDA066)及英国国际发展部(DFID)资助的“中国国际发展研究网路(CIDRN)研究课题系列”的阶段性成果

    A Consideration On Public Rest Place Under the Concept of City Management——With Xiamen as an Example

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    从城市经营理念出发,重审当前公共休憩空间的状况,并指出规划存在的误区并分析其根源,最后结合案例说明城市经营理念在公共休憩空间的意义和具体应用。Based on the conception of city management,the current situation of public rest space was reviewed.Some misunderstanding aspects in planning were pointed out and its origin was analyzed.The significance and special application of city management concept in public rest place was demonstrated by case study

    Entrepreneurship and Economic Growth of China

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    作为市场经济的主体,企业家本身所具有的企业家精神越来越吸引学者的瞩目,成为经济学、管理学等学科的重要研究内容。企业家精神中包含的创新、冒险、竞争、合作等特质也通过促进市场有效竞争,提高生产效率等直接或间接的作用于经济增长,为不断完善中国市场经济体制和促进经济结构转型提供了强大的动力。由于历史原因,我国对企业家精神的研究从21世纪初才大量出现,同时因为企业家精神的不稳定性以及多层次性,许多问题尚未有统一结论,因此本文选择从企业家精神的角度研究当今中国的经济增长,具有理论和现实意义。 本文首先对研究背景、意义等作了简单介绍,然后在国内外学者研究成果的基础上,对企业家以及企业家精神的内涵进行界定,...In the times of knowledge economy, the entrepreneurs as an important human resources, plays an important role in promoting product innovation, technological change and industrial upgrading. As the mainstay of the market economy, the entrepreneurship which has increasingly attracted the attention of scholars, becomes an important research area in economics, management and other disciplines. Entrepr...学位:经济学硕士院系专业:经济学院_政治经济学学号:1532013115217

    Case Study on Defensive Space in Minnan Villages

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    闽南民系的形成,伴随着为生存而竞争冲突的主线。本文通过对闽南防御空间的研究,从文化史、地方史、政治史学和军事工程学的视角,力图比较完面、客观地探讨闽南防御心理下产生特殊的空间形态。The formation of Minnan clan is accompanied with the main line of competition for survival.Based on the anthropologic,local history,political science and military engineering research,this paper discusses some lines of thinking on the interactive relationship between the psychological defense of Minnan and a special form of the space

    Comparative Study of the Development and Influential Factors of Building Control in Taiwan and the Mainland

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    本文以建筑法规作为切入点进行比较,研究台湾与大陆建筑控制的发展历程与动因(社会生活秩序)、各个发展阶段与城市建筑演进的关系。台湾与大陆,一方面,两地具有文化同源、相似的历史发展阶段与社会背景,并且同作为外来文化冲击、交流、融合之地,受到在建筑控制更先进的国家的影响,两地建筑控制的发展具有相似性;另一方面,由于政治制度、社会意识形态、地域环境等不同,两地的建筑控制又并非照搬其它国家,往往必须考虑了各自地域特点后做了适应性改变,因而在城市建筑的发展演进过程中,两地建筑控制的发展又呈现出很大的差异性。本研究在分析台湾与大陆建筑控制发展的基础上,试图探讨社会生活秩序各因素对建筑控制的影响,反思大陆建筑...The thesis takes building regulations as an entry point,to analyze comparative study of the development and influential factors of building control in Taiwan and the Mainland,and also to analyze the relationship in all stages of development of building control and urban architecture. Taiwan and the Mainland, on one hand, both have homologous culture, similar historical stage of development and soc...学位:建筑学硕士院系专业:建筑与土木工程学院建筑系_建筑设计及其理论学号:2522008115177

    The field work of behavioral intention during festival food and beverage consumption ——Follow the example of reunite dinner consumption in Guangzhou region

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    本文以广州地区餐饮消费为例,把团年饭的餐饮消费作为支撑点,开展实证调查,研究顾客在节日外出用餐的消费行为。研究消费人群的经济收入、性别、学历、年龄对节日餐饮消费的影响以及影响顾客行为意向的重要因素。根据调查结果,提出相关的营销建议。 文章主要运用经济学、统计学、社会学、消费者行为学等相关学科理论和关系营销、服务营销、餐饮管理的专业理论知识展开论述。采用实地调查法、文献分析法、相关分析法、因子分析法、多元线性回归分析法来论证影响节日餐饮消费行为意向的概念模型,探究节日餐饮服务中,餐饮企业的服务质量、餐饮品牌、顾客的满意感、信任感相互之间的关系,探讨这些因变量对顾客餐饮消费行为意向的影响。全文在...The study takes examples of catering consumption in Guangzhou area. Concentrating on festival food and beverage marketing based on a number of field surveys and interviews. The study researches into the behavioral intention affected by the economic income, gender, educational background and age structure. The study applies theory of economy, statistics, sociology, consumption behavioral into disc...学位:管理学硕士院系专业:管理学院旅游系_旅游管理学号:X200433003

    Cloning and Prokaryotic Expression of the Silicatein-α Gene in Mycale phyllophila and Activity Assay of the Recombinant Silicatein-α

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    海绵动物是古老的多细胞动物,其骨架中最重要的组成成分是硅质骨针。与硅质骨针形成密切相关的酶被称为硅蛋白(silicatein),属于类木瓜蛋白酶半胱氨酸蛋白酶亚家族,具有由丝氨酸(Ser)、天冬酰胺(Asn)和组氨酸(His)组成的催化三分子和特征性的羟基氨基酸簇,主要作用是参与海绵动物硅质骨针的形成,其在离体条件下对于生物硅沉淀的催化作用在仿生学应用上具有重要的应用价值。 研究对象叶片山海绵(Mycalephyllophila,Hentschel1911)隶属多孔动物门(Porifera)、寻常海绵纲(Demospongiae)、繁骨海绵目(Poecilosclerida)、山海绵科(My...As the most primary multicellular organisms on earth, sponges possess the most novel skeletal elements, siliceous spicules. An enzyme named silicatein, which is considered to be a new member of the papain-like cysteine protease subfamily, is closely related to the formation of siliceous spicules. Silicatien is distinguished by a Ser-Asn-His catalytic triad and characteristic serine cluster, which ...学位:理学硕士院系专业:海洋与地球学院_海洋生物学学号:2232013115141

    The enlightenments of Chinese stand-up discourse theme pattern for the teaching Chinese spoken discourse as a foreign language

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    语言作为人们交流的工具,其本质属性是社会性。口语是语言能力的最重要的表现形式,它是对外汉语任务的重点和难点。能否运用地道的汉语进行无障碍地交流,这是汉语二语习得者学习汉语的主要目的之一。但是,如何教授汉语二语习得者获得地道的口语能力,特别是具有一定汉语基础的习得者继续提高汉语口语水平是当今对外汉语界亟待解决的一项课题。 口语交际的实质在于对语言材料的语篇组织,因此如何让汉语二语习得者更好更快地掌握汉语口语语篇组织的方法就成为了对外汉语口语教学的中心任务。在使用语言进行交际时,存在着对语言材料进行顺序排列的问题。也就是说人们说话时,通常是按照某些词语在交际中所要体现的功能来确定先说哪些话,后说...Language, as a tool of human communication, its fundamental characteristic is sociality. The reflection of one’s language competence is pursuant to his/her ability of oral language. And how to improve this ability becomes to the key point of teaching Chinese as a second language. Hence, the major issue to be addressed in the topic of teaching Chinese as a second language is how to enhance the for...学位:文学硕士院系专业:海外教育学院_语言学及应用语言学学号:2652011115129

    Architecture with the Concept of the living Buddhism——design and extension for Benevolence temple in lianhua mountain in Xiamen

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    本文以厦门莲花山佛心寺扩建规划为例,对如何通过保护与建设、自然与人文、传统与现代、宗教与旅游、出世与入世等二元矛盾问题的综合思考,营造出具有闽南风格的现代佛寺进行的探讨。Facing multi dulity of conservation and renew,human and nature,tradition and modernity,religion and tourism,as well as mundane or supermundane in the course of design and extension for Benevolence temple in lianhua mountain in Xiamen,this paper discusses some liners of thinking on making choice and balance.It is a real exploration of "minnan traditional spirits" for temple planning.项目名称:福建厦门莲花山佛心寺扩建规划设计单位:厦门大学建筑与城市规划研究所项目主持人:罗林教授主要设计人员:黄丹丹、吴一凡、赵晶晶、辜克
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