艾滋病毒重组抗原及第三代艾滋病毒抗体EIA诊断试剂盒的研制

近年来中国的艾滋病毒(HIV)感染人数以每年30％的速度增长,HIV感染者总数已超过60万人,感染者已从吸毒人员、献血员等高危人群扩展到社会各个阶层,我国已处于艾滋病泛滥前的关键时期。HIV诊断试剂盒是HIV防制工作中最重要的技术工具。用于人群筛检的HIV诊断试剂盒已历经三代,第一代试剂盒主要使用来自细胞培养的HIV病毒的裂解产物作为抗原;第二代产品使用基因工程重组抗原和/或人工合成肽作为抗原,使包被抗原中免疫优势区的比例明显增强,从而提高了试剂的灵敏度,而且标准化生产的相对更纯的抗原的使用使试剂的特异性和重复性均大为提高。前两代试剂均采用间接法原理,即先以抗原包被聚丙乙烯板,再加入待检血清,最后加入酶标记的抗人Ig

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies