Analysis of DM Magazines in the Demassify Times

这是一个小众的时代，社会群体分众化，消费行为个性化，营销精细化，适应这样的趋势，传播也由大众传播逐渐走向分众化传播。大量的分众化媒体随之迅速崛起，它们的出现不仅瓜分了受众群体，更因其精准到达目标受众、符合精确营销的要求，成功地瓜分了广告市场的“蛋糕”。除风头正劲的液晶电视媒体以外，DM杂志是发展十分迅速的一种分众媒体。自从1998年北京诞生国内第一本DM杂志《生活速递》以来，这种新型媒体就在全国各主要城市遍地开花，蓬勃发展。本文试图从DM杂志诞生于社会分众化、传播小众化这一种背景下，从它作为一种分众媒体的角度去探讨DM杂志的生存发展状况，以及DM杂志广告的特点。本文主要由以下5个部分组成：第一...This is a demassify ages, social community grouping, consume behavior characteristic, the marketing is fine to turn, adapting such of trend, spread is also headed for a grouping dissemination gradually by mass communications.A great deal of demassify medium are immediately quickly rising, their emergence not only divided to be subjected to many communities, more because it is precise to arrive the...学位：文学硕士院系专业：人文学院新闻传播系_传播学学号：20043202

“使用与满足”理论与科学的受众研究取向

“使用与满足”理论产生于20世纪40年代,研究从考察受众对不同媒介的使用开始,受众的媒介使用行为在很大程度上由个人的需求和兴趣来加以解释。网络传播时代的到来为“使用与满足”理论提供了更大的发展空间。作为一种受众观,“使用与满足”理论依然有许多缺陷。麦考姆斯和韦弗曾提出,将议程设置和使用与满足学说协同起来,构建一种综合了受众中心和媒介中心的新取向。本文认为这才是比较全面、科学的受众研究取向

pJAK2 polypeptide,an antagonist of suppressors of cytokine signaling-1,can enhance the antitumor effect of dendritic cells

目的:探讨细胞因子信号转导抑制因子-1(SuPPrESSOrS Of CyTOkInE SIgnAlIng1,SOCS1)拮抗物PJAk2多肽(氨基酸序列号为1001-1013)参与树突状细胞(dEndrITIC CEllS,dCS)的体外诱导培养后对dCS抗肿瘤作用的影响。方法:采集健康人外周血,离心获得单个核细胞,用重组人粒细胞巨噬细胞集落刺激因子(rECOMbInAnT HuMAn grAnulOCyTE-MACrOPHAgE COlOny STIMulATIng fACTOr,rHgM-CSf)及重组人白细胞介素-4(rECOMbInAnT HuMAn InTErlEukIn-4,rHIl-4)诱导dCS,第5天分为4组:单纯dCS培养(对照)组、抗原负载(lySATE-dCS)组、多肽修饰(PJAk2-dCS)组和抗原与多肽共培养(lySATE+PJAk2-dCS)组,第6天各组加入肿瘤坏死因子-α(TuMOr nECrOSIS fACTOr-AlPHA,Tnf-α)促成熟。倒置显微镜下观察dCS形态;fCM法检测dCS表型;乳酸脱氢酶(lACTATE dEHydrOgEnASE,ldH)细胞毒实验检测各组细胞毒性T淋巴细胞(CyTOTOXIC T lyMPHOCyTE,CTl)对胃癌细胞bgC-823的靶向杀伤作用;ElISA法检测白细胞介素-12(InTErlEukIn-12,Il-12)和γ干扰素(InTErfErOn-γ,Ifn-γ)的水平。结果:与未加入诱导剂组相比,各组均成功诱导出成熟dCS,均高表达Cd80、Cd83、Cd86和人类白细胞dr抗原(HuMAn lEukOCyTE AnTIgEn dr,HlA-dr),但以lySATE+PJAk2-dCS组的表达水平最高。在10:1~30:1的效靶比范围内,CTl杀伤作用与效靶比呈正相关。当效靶比为30:1时,对照组的CTl杀伤率达(19.77±2.34)%,低于其他3组(P<0.01),而lySATE+PJAk2-dCS组较lySATE-dCS组及PJAk2-dCS组都高(P<0.05)。lySATE+PJAk2-dCS组培养上清液中Il-12及Ifn-γ的分泌水平明显高于对照组(P<0.01)。结论:SOCS1拮抗物PJAk2多肽(1001-1013)可增强dCS对胃癌细胞的抗原递呈及特异性抗肿瘤作用。Objective:To investigate the effect of pJAK2 polypeptide,an antagonist of SOCS1(suppressors of cytokine signaling 1),on antitumor effect of in vitro cultivation-induced DCs(dendritic cells).Methods:Peripheral blood was collected from the healthy volunteers,and the PBMCs(peripheral blood mononuclear cells)were isolated.DCs were induced by rhGM-CSF(recombinant human granulocyte-macrophage colony-stimulating factor)and rhIL-4(recombinant human interleukin-4).On the fifth day,DCs were divided into four groups:control group,Lysate-DCs group,pJAK2-DCs group,and Lysate + pJAK2 DCs group.On the sixth day,TNF-α(tumor necrosis factor-alpha)was added into each group.The morphological features of DCs were observed under an inverted microscope;the phenotypes were detected by FCM(flow cytometry);the killing effect of CTLs(cytotoxic T lymphocytes)on gastric cancer BGC-823 cells was evaluated by LDH(lactate dehydrogenase)cytotoxicity test;the concentrations of IL-12(interleukin-12)and IFN-γ(interferon-γ)were detected by ELISA(enzyme-linked immuno sorbent assay).Results:Mature DCs presented typically morphological and phenotypic features;the DCs in Lysate + pJAK2-DCs group had the highest expression levels of CD80,CD83,CD86 and HLA-DR(human leukocyte antigen DR).When the ratio of effectors to target cells ranged from 10:1 to 30:1,the killing activity of CTLs had a positive correlation with the ratio.When the ratio of effectors to target cells was 30:1,the killing activity of CTLs in the control group was(19.77±2.34)%,which was lowest as compared with the other groups(P < 0.01),meanwhile the killing activity of CTLs in Lysate + pJAK2-DCs group was higher than those in Lysate-DCs and pJAK2-DCs groups(P < 0.05).The levels of IL-12 and IFN-γ secretion in Lysate + pJAK2-DCs group were apparently higher than those in the control group(P < 0.01).Conclusion:An antagonist of SOCS1,pJAK2 polypeptide,can enhance the ability of antigen presentation and specific antitumor effect of DCs on gastric cancer cells.南京军区医学科技创新课题资助项目(编号:10MA068); 福建省自然科学基金面上项目(编号:2010D013); 厦门市科技计划创新项目(编号:3502z20104014

Determination of polycyclic aromatic hydrocarbons(PAHs) in tea using solid phase microextraction coupled gas chromatography mass spectrometry

本文优化了萃取条件,建立了顶空-固相微萃取(HS-SPME)、气相色谱-质谱测定茶叶中4种多环芳烃的方法.茶叶中多环芳烃含量和对应的信号强度在0.3~150mg kg~(-1)范围内呈良好的线性关系,检出限为0.1~0.2mg kg~(-1),回收率在72.6%~102.4%之间;茶汤中含量和对应的信号强度在0.01~10mg kg~(-1)范围内呈良好的线性关系,检出限为0.005~0.01mg kg~(-1),回收率为76.4%~103.6%.In this study, GC-MS coupled head-space solid-phase microextraction(HS-SPME) was applied to detect 4 kinds of PAHs in tea and in tea infusion. After the optimization of the experimental consideration, the linear ranges for the PAH4 signal intensity and their concentrations are found to be 0.3–150 and 0.01–10 mg kg~(-1). The detection limit is 0.1–0.2 and 0.005–0.01 mg kg~(-1), with recovery of 72.6%–102.4% and 76.4%–103.6%, respectively

Modulation recognition of underwater acoustic OFDM signals based on the correlation property of the cyclic prefix

为解决非合作通信系统中水声OFDM信号的类型识别,本文研究水声OFDM通信信号与常见单载波水声数字通信信号(MPSK,MFSK)之间的调制识别问题。考虑到水声信道复杂传播特性对循环前缀相关性的影响,本文通过截取信号前后片段并迭代搜索双相关峰进行无需先验知识的水声OFDM通信信号特征参数提取,在此基础上设计了一种基于模糊系统的水声OFDM通信信号识别器。对不同信道条件下海上实录信号数据的识别实验结果表明了本文方法的有效性。In order to identify the type of underwater acoustic OFDM signal in non-cooperative communication system,in this paper,the method to discriminate the orthogonal frequency division multiplexing(OFDM)from common single-carrier digital underwater acoustic communication signals(e.g.MPSK,MFSK)over underwater acoustic channels has been investigated.Considering the correlation characteristics of the cyclic prefix(CP)at the presence of the doubly selective underwater acoustic channels,an iterative dual-peak searching strategy is proposed to extract the CP correlation peak feature without prior knowledge,as the input vector of a fuzzy recognition system for modulation recognition of OFDM signals.The experimental results of modulation classification obtained with field signals at three different underwater acoustic channels show that the proposed method has good performance.国家自然科学基金项目(11274259,11574258);; 福建省自然科学基金项目(2015J01172

卡铂注射液多疗程化疗致过敏性休克一例并文献复习

过敏性休克是外界某些抗原性物质进入已致敏的人体机体后,通过免疫机制在短时间内发生的一种强烈的多脏器受累症候群,在临床上不可预测的、突然发生的、危及患者生命的严重过敏反应[1]。据统计,首次接受卡铂化疗的患者,前5个疗程卡铂过敏发生率<1%,第6个疗程升高至6.5%,≥7个疗程者发生率高达27%,复发患者或累计

Advances in Research of Silicon-based Anode Materials for Lithium Ion Batteries

硅作为地球上储量丰富的材料,因为其具有较高的理论比容量和较低的电压平台而成为最有前途的锂离子电池负极材料.但是,硅负极材料具有较大的体积膨胀效应、低电导率、循环性能差等特点,成为阻碍其商业化的最大障碍.研究者们采取了各种方法来克服这些困难.本文总结了近期硅基负极材料通过纳米化、复合化、结构特殊化等方法来提高电池性能的最新进展,并展望硅基负极材料的发展方向.Silicon materials are attractive candidates for the next generation of lithium-ion batteries due to their high capacity, low operation potential, high abundance in the world.The main challenges for the practical implementation of silicon anodes, however, are the huge volume variation during lithiation and delithiation process and the low cycle life.Recently, significant works have been done to overcome the problems.Here, the research progresses in the silicon based anode materials for Li-ion batteries are reviewed; the problems and prospects for these materials are also discussed.国家自然科学基金项目(61176050

The Preparation of Three-dimensional Porous Silicon by Metal-assisted Chemical Etching

以工业级多晶硅粉为原料,采用金属银诱导化学腐蚀的方法制备出三维多孔硅纳米线结构。系统分析了化学腐蚀硅粉的机理,特别是金属银催化剂对制备过程的影响。实验对比了不同腐蚀条件(腐蚀液温度、沉积银溶液浓度、光照条件等)对样品结构形貌和比表面积的影响。研究发现,腐蚀液温度升高有利于腐蚀过程中化学反应的进行;而沉积银溶液中的Ag nO3浓度适中,有利于样品表面形成分布均匀的孔洞;外部光照可增加光生载流子,促进反应进行,加快腐蚀速率,从而提高样品比表面积。通过优化腐蚀条件,得到形貌较优、比表面积较大(530CM2·g-1)的三维多孔硅纳米线结构。Three-dimensional porous silicon was fabricated by metal-assisted chemical etching of commercial polycrystalline silicon particles.The mechanism of etching process especially the effects of Ag catalyst on the formation of porous silicon were systematically investigated.The dependence of the morphologies of the etched structures on the temperature of etching solution, the outside illumination and the metal salt concentration were also discussed.By optimizing the etching conditions, three-dimensional porous silicon-nanowires with best morphology and highest specific surface area( 530 cm2·g-1) was obtained.国家自然科学基金资助项目(61176050); 福建省中青年教师教育科研项目(JA15651

纳米TiO_2电极的特殊光电化学响应

应用涂膜法、电沉积法和溶胶-凝胶法制备纳米TiO2电极.实验发现,纳米TiO2具有特殊的光电化学响应,其光电流~电位变化出现光电流峰,这一特殊的光电化学性质乃与纳米半导体电极的纳米结构及其特殊的光诱导氧化还原反应机理密切相关