MK2 inhibitor selectively reduces alkali burn-induced inflammation and neovascularization in cornea

眼化学烧伤是一类常见的眼外伤疾病，特别是在发展中国家。与酸性烧伤相比，碱性烧伤更为常见。碱性物质可快速穿透眼前房，导致慢性炎症和角膜浑浊，从而导致严重且持久的视觉缺损。尽管角膜移植手术是一项有效的治疗方法，然而其成功与否取决于角膜的炎症和新生血管是否得到控制。尽管目前有许多用于治疗角膜炎症和新生血管的药物，然而由于其有一定的副作用或仅仅通过缓解症状而非从根本途径进行治疗，因此亟须从发病机制入手寻找新的治疗办法。 持久的角膜炎症与新生血管，不仅会导致永久的视觉缺失，还会使行角膜手术的时机推迟。碱烧伤常伴随着大量炎症细胞浸润和炎症因子表达上调，促新生血管因子和抗新生血管因子的不平衡是导致新生血管...Ocular chemical burns are a common trauma encountered worldwide particularly in the developing countries. They are more frequently a cause of injury than exposure to injurious acids. Caustic agents can readily penetrate into the anterior ocular surface and produce chronic inflammation and opacification resulting in severe and permanent visual impairment. Even though keratoplasty is a viable therap...学位：理学博士院系专业：医学院_生理学学号：2452013015431

Research on the Time Varying Characteristics of the Stock-Bond Correlation in Mainland and Hong Kong

股票和债券作为两种主要的金融资产，其相关关系对投资决策、风险管理、金融产品定价等方面具有重要影响。本文通过研究改革开放以来中国内地资本市场的相关政策变化与宏观经济情况对股票与债券相关关系的影响，辨明股票与债券相关关系的变化机制与影响因素。此外，本文对比了作为新兴资本市场代表的中国内地资本市场与作为发达资本市场代表的中国香港资本市场在股票和债券相关关系变化趋势中的异同，进一步探明股票与债券相关关系的影响机制，并为今后中国资本市场的改革方向提供经验。 本文以中国内地2002年1月-2016年12月以及中国香港2006年12月-2016年12月的数据为样本，采用加入虚拟变量的条件相关系数GARCH...The stock-bond correlation has important influence on investment decision-making, risk management, asset pricing, etc. This article identifies the influential factors of stock-bond correlation by analyzing the policy changes and macroeconomic conditions in mainland China and Hong Kong. Furthermore, this article compares the similarities and differences between mainland China and Hong Kong’s stock-...学位：经济学硕士院系专业：王亚南经济研究院_金融学学号：2772014115274

Comparison on the Treatments of Three Methods for Knee Osteoarthritis

目的 探讨膝关节骨性关节炎（knee osteoarthritis,KOA）的较佳治疗方案。方法 从双氯芬酸钠治疗组（A组）、正清风痛宁口服治疗组（B组）、正清风痛宁关节腔注射与片剂序贯疗法组（C组）各随机抽取60例病例,比较3组治疗前后疗效、不良反应等指标。结果 3组患者治疗后的Lequesne指数均较治疗前下降（P均〈0.01）;A组治疗后的Lequesne指数与B组差异无统计学意义（P〉0.05）;C组治疗后的Lequesne指数均低于A组与B组（P均〈0.01）。A、B、C 3组治疗总有效率分别为73.3%、75.0%、93.3%,A组疗效与B组比较差异无统计学意义（P〉0.05）,C组疗效优于A组与B组（P均〈0.01）。A、B、C 3组不良反应发生率分别为26.7%、10.0%、11.7%,A组不良反应发生率高于B组与C组（P均〈0.05）;B组与C组的不良反应发生率差异无统计学意义（P〉0.05）。结论 正清风痛宁关节腔注射与片剂序贯疗法治疗KOA疗效好,不良反应较少。Objective To investigate the better treatments of knee osteoarthritis.Methods Randomly selected 60 case from each of the following groups：diclofenac sodium treatment group（A）,zhengqingfengtongning oral treatment group（B）,zhengqingfengtongning articular cavity injection with tablet sequential therapy group（C）.Comparative analysis of the curative effect before and after treament,effective rate and the incidence of adverse reactions between each group.Results The lequesne index of all the 3 groups dropped significantly before and after treament（P〈0.01）.Compared each group after treatment,A and B had no statistical difference（P〉0.05）,C was significantly lower than A and B（P〈0.01）.The total effective rate of A,B and C were 73.3%,75.0% and 93.3%,A and B had no statistical difference（P〉0.05）,C was better than A and B（P〈0.01）.The incidence of adverse reactions of A,B and C were 26.7%,10.0% and 11.7%;A higher than B and C（P〈0.05）,but B and C had no significant difference（P〉0.05）.Conclusion Zhengqingfengtongning articular cavity injection with tablet sequential therapy have good curative effect and less adverse in treatment of KOA,worthy of clinical recommendations

Necessity of treating subclinical hypothyroidism in early pregnant women

目的评估早孕妇女亚临床甲状腺功能减退症(subclinical hypothyroidism,SCH)对妊娠结局的影响及药物治疗的必要性。方法收集18 243例在厦门大学附属第一医院产前检查直至分娩的病例,诊断标准为妊娠10~12周产前检查时TT4与FT4正常而TSH≥2.5 m IU/L为SCH,甲状腺过氧化物酶抗体(thyroid peroxidase antibody,TPOAb)≥34 U/L为阳性。根据TSH的升高程度不同、TPOAb情况、能否遵医嘱按时按量服用L-T4使TSH控制在正常范围内进行分组:2.5 m IU/L≤TSH≤5.0 m IU/L且TPOAb阳性且能遵医嘱者为A组,不能遵医嘱者为B组;TSH>5 m IU/L且TPOAb阳性且能遵医嘱者为C组,不能遵医嘱者为D组;2.5 m IU/L≤TSH≤5.0 m IU/L且TPOAb阴性且能遵医嘱者为F组,不能遵医嘱者为G组;TSH>5 m IU/L且TPOAb阴性且能遵医嘱者为H组,不能遵医嘱者为K组。并随机抽取200例同期甲状腺功能正常的病例作为对照组(E组),回顾分析早孕妇女甲状腺功能异常的发生率、SCH对妊娠结局的影响、早孕妇女SCH行左旋甲状腺素片(L-T4)替代治疗的剂量及影响因素。结果早孕妇女SCH检出率为5.20%,甲状腺功能正常率为79.00%。A组早产3.31%(8/242)、妊娠期高血压7.02%(17/242)、胎儿生长受限7.02%(17/242)、出生低体质量儿6.61%(16/242)的发生率均低于B组的8.79%(8/91)、14.29%(13/91)、15.38(14/91)、14.29(13/91)(P均 5 m IU / L,TPOAb was positive and had good compliance; Group D: TSH and TPOAb as Group C but not have good compliance; Group F: 2. 5 m IU / L≤TSH≤5. 0 m IU / L,TPOAb was negative and had good compliance; Group G: as Group F,but not have good compliance; Group H: TSH > 5 m IU / L,TPOAb was negative and had good compliance; Group K: as Group H,but not have good compliance. Randomly selected 200 cases with normal thyroid function at the same period as the control group( Group E). Retrospective analysis the occurrence rate of thyroid gland dysfunction,the influence of SCH to pregnancy outcome,the doses and influencing factors of replacement therapy by L-T4 to SCH of early pregnant women. Results Relevance ratio of SCH in early pregnant women was5. 20%,the ratio of normal thyroid function was 79. 00%. In group A,premature birth 3. 31%( 8 /242),gestational hypertension 7. 02%( 17 /242),fetal growth restriction 7. 02%( 17 /242),low birth weight infant 6. 61%( 16 /242),were lower than that in group B 8. 79%( 8 /91),14. 29%( 13 /91),15. 38( 14 /91),14. 29( 13 /91) respectively( P < 0. 05). In group C,spontaneous abortion 3. 31%( 6 /181),premature birth 3. 89%( 7 /181),gestational hypertension 8. 29%( 15 /181),gestational diabetes mellitus 3. 89%( 7 /181),fetal growth restriction 7. 73%( 14 /181),low birth weight infant 6. 63%( 12 /181),were lower than that in group D 11. 54%( 6 /52),11. 54%( 6 /52),19. 23%( 10 /52),11. 54%( 6 /52),17. 31( 9 /52),15. 38( 8 /52)( P < 0. 05). No significant statistical difference were found in multiple comparison of the above six indexes of group A,B,C. And just the same as the multiple comparison of group F,G,H,K,E. When TSH reach the standard,the dosage of L-T4 in group A and C had significant difference [( 0. 757 ± 0. 378 vs. 1. 106 ± 0. 454) μg / kg,t = 8. 39,P < 0. 001]. There were also significant differences of group F compared with group H[( 0. 443 ± 0. 198 vs. 0. 813 ± 0. 378) μg/kg,t = 8. 22,P < 0. 001],group( A + F) compared with group( C + H) [( 0. 634 ± 0. 358 and 1. 017 ±0. 427) μg / kg,t = 11. 77,P < 0. 001],group A compared with group F [( 0. 757 ± 0. 378 vs. 0. 443 ± 0. 198) μg / kg,t = 9. 85,P < 0. 001 ],group C compared with group H [( 1. 106 ± 0. 45 vs. 0. 813 ± 0. 378) μg / kg,t = 5. 59,P < 0. 001],group( A + C) compared with group( F + H) [( 0. 932 ±0. 463 vs. 0. 693 ± 0. 388) μg / kg,t = 6. 53,P < 0. 001]. Conclusion The early pregnant women with SCH and TPOAb positive could increase the occurrence rate of spontaneous abortion,premature birth,gestational hypertension,gestational diabetes mellitus,fetal growth restriction and low birth weight infant. The early intervening treatment of L-T4 could efficiently decrease the adverse event occurrence ratio of pregnant woman with SCH and positive TPOAb,but no effect for that with SCH and TPOAb negative. The TSH level and condition of TPOAb could affect the replacement therapy dosage of early pregnancy with SCH

Research of State-owned Enterprise Groups Comprehensive Budget Management Issues ---Take SINOCHEM as the example

在21世纪新的经济环境下，经济周期大大缩短、市场变化迅速，基于过去的经验也不再是未来的标杆和指示器。因此，管理的计划和控制职能变得越来越重要，成为企业管理的核心任务，而实现这些职能的一个重要手段就是实行全面预算管理。 随着我国现代企业制度的推行，全面预算管理已成为国有企业集团加强管理的必然选择。虽然大部分国有企业集团采用了预算管理，但许多企业还存在认识上的偏差和误区，预算管理具体实施不科学，在推行预算管理上尚未形成正确的全面预算管理理念，使得全面预算管理实施成效大打折扣，全面预算管理的导向和控制作用未能得到充分发挥。究其原因，主要在于：（1）预算管理的前提不到位，存在制度缺陷和文化缺陷；（2...As the introducing of China's modern enterprise system, comprehensive budget management has become a natural choice for state-owned enterprise groups to strengthen management. But we can see from the current practice that it has not yet brought about good effect, which means the role of comprehensive budget management to orient and control has not yet been fully played. It mainly due to: (1) The p...学位：工商管理硕士院系专业：管理学院高级经理教育中心（EMBA项目）_高级管理人员工商管理硕士(EMBA)学号：X20051513

对会计有阶级性质疑

对会计有阶级性质疑陈丰中国会计向国际会计惯例靠拢，已成为我国会计改革的目标取向。但有的同志对此仍存有疑虑。之所以会出现这样的情况，归根到底，还是由于未能摆脱长期形成的“会计阶级性”问题的困扰所致。例如，杨雄胜同志认为：“‘增减’好还是‘借贷’好、‘定..

浅论高等学校分类与定位的若干理论问题

界定了高等学校分类与定位概念的内涵与外延。探讨了高等学校的类型和层次,分类与定位,以及分类、定位与评价三者之间的关系,为深入研究我国高等学校分类与定位问题提供了参考

中国高校分类标准及指标体系设计

高校分类标准是指用来区分高校性质、任务、能级的准则和参照系,是用于判断高校类型和层次的定性化尺度;高校分类指标是指在分类标准基础上用于测量或反映高校性质、任务、能级及发展现状的数量指征。高校分类标准及指标,应当从输入、多元的视角来设计。本文尝试从培养目标及学科专业、人才培养、科学研究、社会服务、学生成份、教师队伍、经济(地理)区域、宏观管理等八个维度,来设计中国高校的多元分类标准及指标体系

A Study of the Strategy and Tactics for Translating Children’s Literature from English into Chinese: Based on the Translation of Chapters 11 and 12 of A Summer of Horses

本论文参考了大量的期刊杂志、学位论文以及一些关于翻译的研究著述，通过实际的项目操作，笔者探析了儿童文学翻译中遇到的问题，并就应该采用什么策略和技巧的问题提出了自己的见解。 本论文先是对一些国内外的相关研究进行简单的综述，分析国内外的研究状况，从前人的研究中寻找有助于本文写作的重要资料；通过翻译实践项目，对《马背上的夏天》第十一、十二章的原文进行探索并做出中文译文；然后对翻译实践中遇到的问题和采用的策略、技巧进行总结归纳，对作家和作品进行简单的介绍。从理论入手探讨了翻译儿童文学作品所需采用的翻译策略，探究了句法和词义的翻译技巧。最后，是对此次翻译项目实践的总结和不足之处的探讨。This thesis draws on a great number of journal articles, dissertations, textbooks and monographs on translation. It aims at exploring and analyzing the problems that are commonly encountered in real practice as well as the strategies and skills that should be adopted. This thesis consists of four chapters, including an introduction and a conclusion. Chapter One briefly introduces previous studies...学位：翻译硕士院系专业：外文学院_翻译硕士学号：X200811002

The Applied Research of Noble Metal Nanomaterials as Peroxidiase Mimic

贵金属纳米材料模拟酶由于克服了天然酶类容易受环境中物理、化学因素影响而失活的缺陷,同时由于纳米材料具有的高体表面积比及在生物稳定性、光谱特性方面的优越性,使其研究备受关注。H2O2是多种反应的中间产物,在食品、环境、工业、制药等邻域有重要作用,因此对贵金属纳米材料模拟过氧化物酶的研究意义重大。目前关于其应用的研究主要有如下方面:离子检测(如Hg2+、Pb2+、k+);有机化合物检测(如葡萄糖、黄嘌呤、小鼠白介素Ⅱ)以及肿瘤细胞检测。Noble met al nanomaterials used as enzyme mimics are a current interest,because they can overcome the disadvantages of natural enzymes whose catalytic activity can be inhibited by the physical and chemical factors of environment,and they have large surface-to-volume ratio,good properties in biology and spectrum.H2O2 is a intermediate product of many kinds of reactions,and plays an important part in food,environment,industrial and pharmaceutical.Therefore,the research of noble met al nanomaterials as peroxidiase mimics is of great significance.At present,the mainly applied research include ion detection( e.g.Hg2 +,Pb2 +,K+),organic chemical compound detection( e-.g.glucose,xanthine,mouse interleukin 2),and the detection of tumour cell