66 research outputs found

    《逃离魔法师》的女性主义解读

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    通过考察《逃离魔法师》中女性在教育、职业生涯和两性关系方面所面临的不平等以及男性阴影下的女性间的友谊,发现二战后父权制传统下的女性仍是由男性定义的他者,力争平等自由的主体地位的女性难以摆脱在男性的魔咒下矛盾挣扎的命运,性别藩篱下的女性友谊也难以升华成真正的友谊。《逃离魔法师》反映了二战后英国各阶层的女性在以男性为中心的父权制社会仍处于从属地位的真实处境与生存状态,揭示了默多克思想脉络里潜藏的女性主义意识

    气相爆轰波在障碍物上Mach反射后流场的分析

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    详细分析了气相爆轰波在斜劈上Mach反射后的流场。根据胞格结构的烟迹记录,得到了爆轰波Mach反射时三波点迹线与楔面的夹角X与楔角θ的定量关系,依此推算出爆轰波绕射楔块 时从规则反射向Mach反射转变的临界角范围。论文也分析了影响X角和Mach杆后压力的主要 因素。该结果有助于更深入了解爆轰波的本质,也为数值模拟气相爆轰波在障碍物上Mach反射现象提供了可靠的对照依据

    基于电荷共享缓冲输出的LCD驱动电路设计

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    随着手持移动设备使用的增加,液晶显示器驱动芯片的功耗问题越来越受到人们的关注,如何减少芯片功耗已经成为设计的重点。设计一款适用于小尺寸液晶显示器的驱动芯片,采用rail-to-rail缓冲放大器和电荷共享技术的列驱动缓冲输出电路。设计中采用rail-to-rail缓冲放大器适应驱动电路的电压极性特点,可以很好地减少静态功耗;并且充分利用了点反转驱动方法相邻行和列电压极性均不相同的特点,采用了一种新的电荷共享技术,使其相邻的行和列相互充电,使动态功耗在理论上减少到原来的25%

    生物离子分子组学计划( Bio-imOmics Project:BiP)

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    “imOmics 离子分子组学”是对生命与非生命物质与外界环境进行离子和分子交换过程的整体研究。依据研究的对象不同可以分为: • “非生物离子分子组学计划(Abiotic imOmics Project:AiP)” • “生物离子分子组学计划(Bio-imOmics Project:BiP)” 生物离子分子组学计划(Bio-imOmics Project:BiP)是利用现代NMT非损伤微测技术等活体离子分子检测技术,结合现代计算机人工智能等科技及生物信息学方法,对生物个体及其各层级组成与外部环境之间,以离子和分子形式进行能量和信息交换的过程,进行系统的、可量化的研究,从整体活体生理机制水平上拓展人类对生命现象的认知和利用

    ULK1 phosphorylates Exo70 to suppress breast cancer metastasis

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    乳腺癌是威胁女性生命健康的“头号杀手”,而远处转移是乳腺癌患者死亡的主要原因。因此,了解乳腺癌如何发动侵袭和转移,对于有效治疗乳腺癌、延长病人生存期具有重要意义。本研究中,该团队发现ULK1通过结合并磷酸化胞泌蛋白复合体关键亚基Exo70来抑制乳腺癌转移。ULK1对Exo70上Ser47,Ser59和Ser89位点的磷酸化,严重地削弱了Exo70的自身寡聚化和与其它胞外分泌复合体亚基的结合,进而减少了细胞运动伪足形成以及基质金属蛋白酶的分泌,从而抑制乳腺癌细胞的迁移和侵袭。该论文首次揭示了胞外分泌复合体重要成员Exo70在乳腺癌中受到ULK1和ERK1/2的双重磷酸化调控,从而使得乳腺癌细胞可以根据外环境来决定潜伏还是发动侵袭转移,为乳腺癌的治疗提供了新的理论基础。 本论文的通讯作者为占艳艳副教授、郭巍教授和胡天惠教授。医学院博士生毛丽媛、占艳艳副教授、吴斌博士和医学院博士生于强为共同第一作者。【Abstract】Increased expression of protein kinase ULK1 was reported to negatively correlate with breast cancer metastasis. Here we report that ULK1 suppresses the migration and invasion of human breast cancer cells. The suppressive effect is mediated through direct phosphorylation of Exo70, a key component of the exocyst complex. ULK1 phosphorylation inhibits Exo70 homo-oligomerization as well as its assembly to the exocyst complex, which are needed for cell protrusion formation and matrix metalloproteinases secretion during cell invasion. Reversely, upon growth factor stimulation, Exo70 is phosphorylated by ERK1/2, which in turn suppresses its phosphorylation by ULK1. Together, our study identifies Exo70 as a substrate of ULK1 that inhibits cancer metastasis, and demonstrates that two counteractive regulatory mechanisms are well orchestrated during tumor cell invasion.This work was supported by the grants from the National Natural Science Foundation of China (81572589, U1405228, 81472568, and 31770860), the Natural Science Foundation of Fujian grant (2017J06020, 2018J01400, 2017R1036-4, 2017R1036-6, 2016R1034-1, and 2016R1034-4), and the Xiamen Science and Technology grant (3502Z20159013) to Y.-y.Z. and T.H., and National Institute of Health R01 GM111128 to W.G.该论文的研究成果是在国家自然科学基金和福建省基金的资助下,与美国宾夕法尼亚大学和清华大学共同协作完成的

    On the Mother-Daughter Relationships under the Pen of Hurston and Morrison

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    佐拉·尼尔·赫斯顿和托尼·莫里森分别在《他们眼望上苍》和《秀拉》中塑造了不朽的黑人女性形象。借用心理分析学家南茜·乔多萝的客体关系理论,从女性主义的视角,对比分析在种族、性别和阶层的桎梏下寻求独立的女主人公们与她们母亲间错综复杂的关系:母爱对女主人公来说或是分离的残酷现实,或是对自我成长的限制,或是难以摆脱的依恋,母亲的影响对女性性格的塑造、自我意识的发掘和女性身份的认同起到限制或推动性的作用。Two renowned black female writers Zora Neale Hurston and Toni Morrison have portrayed the enduring images of the black women respectively in their novels Their Eyes were Watching God and Sula.The feminist psychoanalyst Nancy Chodorow's theory of the reproduction of mothering is applied to analyze the complicated relations between the three heroines and their mothers living under the fetters of racism, sexism and classism- maternal bonds could be cruel separation or restriction of one's selfhood or unbreakable attachment for the heroines- in order to shed light on the mothers' restrictive or empowering influence on the formations of their daughters' personality,self-awareness and their identity as a black female in the society

    A Special Work of the Academic History of English Literary Studies-A Review of Zhang Helong’s English Literary Studies in China

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    在《英国文学研究在中国》一书中,著者梳理了一百多年来英国文学研究在中国的学术发展历程,展现了中国学人在该领域取得的重要成就,反思了研究中存在的问题和不足.该书采用“总述”与“分述”的撰写思路,潜探学术史脉,深绎学理路径,同时以问题意识为导向,兼具学者个案分析,指出中国学者应克服影响的焦虑以建构自身的主体性,是一部学术史研究的特色之作,具有较高的学术参考价值.In English Literary Studies in China, scholar Zhang Helong examines the academic developing pro-cess of English literary studies in China since a century ago, displays the dazzling achievements made by Chi-nese scholars in this feld and refects the problems and deficiencies still existing in their researches. Adopting the method of summary and separate narration, Zhang Helong attempts to explore the academic skeleton and interprets the theoretic path. Meanwhile, the book is also problem-oriented, equipped with case studies. The book also points out that Chinese scholars need to overcome their anxiety of infuence, thus construct their own sub-jectivity. The book defnitely is a special work in the aca-demic studies and worth making reference to

    火炬松胚性细胞悬浮培养物的生长参数变化

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    以火炬松成熟合子胚来源的胚性愈伤组织为材料建立了胚性细胞悬浮系,测定了其培养物的鲜重、干重、细胞体积和胚数及培养液中的pH值、电导率和蔗糖浓度等生长参数在培养过程中的变化动态。结果表明,在培养周期内,培养液中的pH值、电导率和蔗糖浓度的逐步降低与培养物的鲜重、干重、细胞体积和胚胎数的逐步增加保持一致性。在培养至18 ̄21d,pH值、电导率和蔗糖浓度均接近或降到最低点,而胚数及细胞体积的增长都达到

    气相爆轰波与空气冲击波在斜劈上Mach反射的特征参数比较

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    以传统的烟迹技术记录胞格结构,证实了气相爆轰波在管道中与斜劈相互作用发生Mach反射,得到了系统的实验结果。在此基础上详细地分析了爆轰波反射后流场的特征参数(三波点迹线与楔面的夹角X与斜劈楔角Θ及气体初压P_0的关系等),并与空气冲击波在斜劈上Mach反射后流场的特征参数进行了比较,初步探讨了参数偏差的原因。这一研究有助于了解爆轰波的前导冲击波和横波在Mach反射中所起的作用

    火炬松胚性悬浮细胞原生质体的分离和培养

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    以火炬松(PinustaedaL.)成熟合子胚的胚性悬浮细胞为材料分离原生质体,研究了酶液组成、渗透压稳定剂和悬浮细胞生长期对原生质体产量和原生质体活力的影响。结果表明:酶液组成为CelulaseRS1%+CelulaseR-102.5%+PectolyaseY-230.2%、渗透压稳定剂为甘露醇,在悬浮细胞处于对数生长期时,原生质体的产量和活力均最高。高活力的原生质体在DCR培养基上培养6d后完成第1次分裂,4周后形成胚性细胞团,8周后形成胚性胚柄细胞团(ESM:Embryonalsuspensormass),16周后胚性顶端分化出子叶原基
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