The Synthesis and Application of Phthalocyanine-silica Nano-materials

摘要 本论文共分为五章，包括绪论、四羧基铝酞菁纳米粒子、四羧基铁酞菁纳米粒子及多功能磁性二氧化硅纳米管的制备与应用和展望。 第一章为绪论，介绍了不断发展的纳米科技，对用作标记物的荧光纳米材料做了小结，着重讲述了二氧化硅纳米粒子的应用与合成，并对多功能纳米材料－超顺磁性二氧化硅纳米粒子和纳米管的应用做了简介，并在此基础上提出了本论文选题依据、研究目标、和研究内容。 第二章主要研究四羧基铝酞菁纳米粒子的制备与应用。本章分为两节，第一节主要通过四乙氧基硅烷在反向胶束构成的纳米水池中水解首次制备出非共价四羧基铝酞菁纳米粒子，该荧光纳米颗粒能用于指示溶液pH的变化。第二节主要通过四羧基铝酞菁修饰的...Abstract This dissertation consists of five chapters, including introduction, synthesis and application of tetra-substituted carboxyl aluminum phthalocyanine (AlC4Pc)-silica nanoparticles, synthesis and applicantion of tetra-substituted carboxyl iron phthalocyanine(TCFePc)-silica nanoparticles, synthesis and applicantion of multifunctional magnetic silica nanotubes, and the conclusion and p...学位：理学硕士院系专业：化学化工学院化学系_无机化学学号：20042500

Preparation and Application of AlC_4Pc-Magnetic Silica Nanotubes

In this study,we report the preparation and application of the AlC4Pc-magnetic silica nanotubes(AlC4Pc-MSNs),which was synthesized via alumina template membrane method.The synthesized outer-NH2-magnetic silica nanotubes(outer-NH2-MSNs)were characterized by TEM,SEM,EDS and SQUID.Besides these,UV-Vis absorption spectra and fluorescence spectra were also recorded,which further indicate that the AlC4Pc-MSNs have the similar features with free AlC4Pc.The AlC4Pc-MSNs not only have all the advantages of silica nanotubes,but also can be easily separated from the solution by external magnetic field.On the basis of the merits mentioned above,AlC4Pc-MSNs was used for the detection of pH value.Our work herein reveals that the outer-NH2-MSNs will be a promising platform for the applications of the targeting drug delivery,DNA transfection,selective separation,catalyst carriers and so on.国家自然科学基金(批准号:20575055);; 国家基础科学人才培养基金(批准号:J0630429)资

Preparation of novel tetra-substituted carboxyl aluminum phthalocyanine-silica fluorescent nanoparticles and application to acidity measurements

Novel fluorescent nanoparticles, entrapping water-soluble red-region fluorescent dye of tetra-substituted carboxyl aluminum phthalocyanine AlC4Pc), have been synthesized and characterized. Adding an appropriate. amount of AlC4Pc and concentrated ammonia water into the microemulsions prepared by mixing 1.00 mL of Triton X-100; 12. 30 mL of cyclohexane, 1. 04 mL of n-hexanol to form the reverse micelle, after stirring for 10 min the mixture was then added tetraethoxysilane; 'vigorously stirring to impel tetraethoxysilane diffused into the nanoreactor. Under the catalysis of ammonia., tetraethoxysilane hydrolysed and polymerized to form the silica nanoparticles. These nanoparticles had unique advantages of high fluorescence 'good photost ability, and biocompatibility. The possibility of using the fluorescent nanoparticles as new fluorescent indicator for pH determination was also investigated. It was found that the fluorescence nanoparticles are pH sensible and the pH response range is between 5. 02, and 11. 98. The proposed method has been successfully applied to the determination the pH of running water and simulating biologic system. The method promises to be used to in-vivo, rate-time determination of H+ in cell

Preparation of Novel Tetra-Substituted Carboxyl Aluminum Phthalocyanine-Silica Fluorescent Nanoparticles and Application to Acidity Measurements

[中文文摘]首次制备出红区荧光染料四羧基铝酞菁掺杂的二氧化硅纳米粒子,并对其进行了表征。将环己烷、正己醇和表面活性剂Triton X-100按一定体积比(12.3∶1.04∶1)混合均匀,形成清澈透明的溶液;将适量的四羧基铝酞菁溶解到浓氨水中,加入到上述混合溶液中,形成反向胶束。搅拌10 m in后加入一定量的四乙氧基硅烷,加快搅拌速度,促使四乙氧基硅烷进入反相胶束中的“纳米水池”,在碱性条件下,四乙氧基硅烷水解形成二氧化硅纳米粒子。采用该方法制备的核壳荧光纳米颗粒荧光稳定性强,生物相容性高,抗干扰能力强。将一定量四羧基铝酞菁掺杂的二氧化硅纳米粒子溶于水溶液中,随溶液pH值的增加,荧光强度增强,并在pH 5.02~11.98的范围内,荧光强度与溶液酸度有良好的线性关系。该法已成功地用于自来水和模拟生物体系中pH的测定。预期该技术有望用于细胞内H+的实时监测。[英文文摘]Novel fluorescent nanoparticles, entrapping water-soluble red-region fluorescent dye of tetra-substituted carboxyl aluminum phthalocyanine(AlC_4Pc),have been synthesized and characterized.Adding an (appropriate) amount of AlC_4Pc and concentrated ammonia water into the microemulsions prepared by mixing(1.00 mL) of Triton X-100,12.30 mL of cyclohexane,1.04 mL of n-hexanol to form the reverse micelle,after stirring for 10 min the mixture was then added tetraethoxysilane,vigorously stirring to impel tetraethoxysilane diffused into the nanoreactor. Under the catalysis of ammonia, tetraethoxysilane hydrolysed and polymerized to form the silica nanoparticles. These nanoparticles had unique advantages of high fluorescence, good photostability, and biocompatibility. The possibility of using the fluorescent nanoparticles as new fluorescent indicator for pH determination was also investigated. It was found that the fluorescence nanoparticles are pH sensible and the pH response range is between 5. 02 and 11. 98. The p roposed method has been successfully app lied to the determination the pH of running water and simulating biologic system. The method p romises to be used to in-vivo, rate-time determination of H+ in cell.厦门市科技创新项目(No.3502Z20022005

Preparation and application of AlC4Pc-magnetic silica nanotubes

In this study, we report the preparation and application of the AlC4Pc-magnetic silica nanotubes AlC4Pc-MSNs), which was synthesized via alumina template membrane method. The synthesized outer-NH2-magnetic silica nanotubes(outer-NH2-MSNs) were characterized by TEM, SEM, EDS and SQUID. Besides these, UV-Vis absorption spectra and fluorescence spectra were also recorded, which further indicate that the AlC4Pc-MSNs have the similar features with free AlC4Pc. The AlC4Pc-MSNs not only have all the advantages of silica nanotubes, but also can be easily separated from the solution by external magnetic field. On the basis of the merits mentioned above, AlC4Pc-MSNs was used for the detection of pH value. Our work herein reveals that the outer-NH2-MSNs will be a promising platform for the applications of the targeting drug delivery, DNA transfection, selective separation, catalyst carriers and so on

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies